A component of excitation-contraction coupling triggered in the absence of the T671-L690 and L720-Q765 regions of the II-III loop of the dihydropyridine (alpha(1s)) pore subunit

We conducted a deletion analysis of two regions identified in the II-III loop of alpha1S, residues 671-690, which were shown to bind to ryanodine receptor type 1 (RyR1) and stimulate RyR1 channels in vitro, and residues 720-765 or the narrower 724-743 region, which confer excitation-contraction (EC)...

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Veröffentlicht in:	Biophysical journal 2001-12, Vol.81 (6), p.3294
Hauptverfasser:	Ahern, Chris A, Bhattacharya, Dipankar, Mortenson, Lindsay, Coronado, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Calcium Membranes Mutation Proteins
Online-Zugang:	Volltext
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