Synthesis of 1-Alkyl-5-amino-1,2,4-triazoles Based on Nucleophilic Substitution and Reduction Reactions

Synthesis of 1-Alkyl-5-amino-1,2,4-triazoles Based on Nucleophilic Substitution and Reduction Reactions

A series of 1-alkyl-5-amino-1 H -1,2,4-triazoles were synthesized starting from 3,5-dibromo-1 H - 1,2,4-triazole by alkylation and subsequent nucleophilic substitution of the 5-bromine atom by azido group, reduction of the latter to amino group, and hydrodebromination.

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Veröffentlicht in:Russian journal of organic chemistry 2018-10, Vol.54 (10), p.1537-1547
1. Verfasser: Tolstyakov, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Bromine
Chemical reduction
Chemical synthesis
Chemistry
Chemistry and Materials Science
Organic Chemistry
Substitutes
Triazoles
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Zusammenfassung:A series of 1-alkyl-5-amino-1 H -1,2,4-triazoles were synthesized starting from 3,5-dibromo-1 H - 1,2,4-triazole by alkylation and subsequent nucleophilic substitution of the 5-bromine atom by azido group, reduction of the latter to amino group, and hydrodebromination.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428018100160