Non-trauma mortality in elderly women with low bone mineral density
9704 ambulatory women aged 65 years or older were prospectively studied to determine whether low bone mineral density (osteopenia) was associated with mortality. Bone mineral density was measured at entry to the study by single-photon absorptiometry. 299 women died during a mean of 2·8 years' f...
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| Veröffentlicht in: | The Lancet (British edition) 1991-08, Vol.338 (8763), p.355-358 |
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| creator | Browner, W.S. Seeley, D.G. Cummings, S.R. Vogt, T.M. |
| description | 9704 ambulatory women aged 65 years or older were prospectively studied to determine whether low bone mineral density (osteopenia) was associated with mortality. Bone mineral density was measured at entry to the study by single-photon absorptiometry. 299 women died during a mean of 2·8 years' follow-up. Osteopenia was associated with increased non-trauma mortality, probably because it is a marker for several other adverse factors. Each standard deviation decrease in proximal radius bone mineral density (0·104 g/cm2) was associated with a 1·19-fold increase in mortality (95% confidence interval 1·04-1·36), adjusted for age and duration of follow-up. Diminished bone mineral density at the proximal radius was strongly associated with deaths from stroke (relative risk=1·74; 95% Cl 1·2-2·70), an association that was not confounded by history of previous stroke, hypertension, postmenopausal use of oestrogen, thiazide diuretic treatment, diabetes mellitus, and smoking. Most deaths in women with low bone mineral density are unrelated to the occurrence of fractures—an observation that should be taken into account when estimating the need for and cost-effectiveness of bone-density screening and fracture prevention programmes. |
| doi_str_mv | 10.1016/0140-6736(91)90489-C |
| format | Article |
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Bone mineral density was measured at entry to the study by single-photon absorptiometry. 299 women died during a mean of 2·8 years' follow-up. Osteopenia was associated with increased non-trauma mortality, probably because it is a marker for several other adverse factors. Each standard deviation decrease in proximal radius bone mineral density (0·104 g/cm2) was associated with a 1·19-fold increase in mortality (95% confidence interval 1·04-1·36), adjusted for age and duration of follow-up. Diminished bone mineral density at the proximal radius was strongly associated with deaths from stroke (relative risk=1·74; 95% Cl 1·2-2·70), an association that was not confounded by history of previous stroke, hypertension, postmenopausal use of oestrogen, thiazide diuretic treatment, diabetes mellitus, and smoking. Most deaths in women with low bone mineral density are unrelated to the occurrence of fractures—an observation that should be taken into account when estimating the need for and cost-effectiveness of bone-density screening and fracture prevention programmes.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(91)90489-C</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Absorptiometry ; Biocompatibility ; Biological and medical sciences ; Biomedical materials ; Bone density ; Bone mineral density ; Bones ; Confidence intervals ; Diabetes mellitus ; Disease ; Diseases of the osteoarticular system ; Estrogens ; Fatalities ; Fractures ; Geriatrics ; Hypertension ; Medical research ; Medical sciences ; Minerals ; Mortality ; Older people ; Osteopenia ; Osteoporosis. Osteomalacia. Paget disease ; Photon absorptiometry ; Post-menopause ; Radius ; Smoking ; Trauma ; Women</subject><ispartof>The Lancet (British edition), 1991-08, Vol.338 (8763), p.355-358</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Aug 10, 1991</rights><rights>Copyright Elsevier Limited Aug 10, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-94eb7c7764497e533009377f254f2003a3142591e073224a2aede24f91d42dbe3</citedby><cites>FETCH-LOGICAL-c354t-94eb7c7764497e533009377f254f2003a3142591e073224a2aede24f91d42dbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0140-6736(91)90489-C$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4942006$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Browner, W.S.</creatorcontrib><creatorcontrib>Seeley, D.G.</creatorcontrib><creatorcontrib>Cummings, S.R.</creatorcontrib><creatorcontrib>Vogt, T.M.</creatorcontrib><creatorcontrib>For The Study Of Osteoporotic Fractures Research Group</creatorcontrib><title>Non-trauma mortality in elderly women with low bone mineral density</title><title>The Lancet (British edition)</title><description>9704 ambulatory women aged 65 years or older were prospectively studied to determine whether low bone mineral density (osteopenia) was associated with mortality. Bone mineral density was measured at entry to the study by single-photon absorptiometry. 299 women died during a mean of 2·8 years' follow-up. Osteopenia was associated with increased non-trauma mortality, probably because it is a marker for several other adverse factors. Each standard deviation decrease in proximal radius bone mineral density (0·104 g/cm2) was associated with a 1·19-fold increase in mortality (95% confidence interval 1·04-1·36), adjusted for age and duration of follow-up. Diminished bone mineral density at the proximal radius was strongly associated with deaths from stroke (relative risk=1·74; 95% Cl 1·2-2·70), an association that was not confounded by history of previous stroke, hypertension, postmenopausal use of oestrogen, thiazide diuretic treatment, diabetes mellitus, and smoking. Most deaths in women with low bone mineral density are unrelated to the occurrence of fractures—an observation that should be taken into account when estimating the need for and cost-effectiveness of bone-density screening and fracture prevention programmes.</description><subject>Absorptiometry</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Bones</subject><subject>Confidence intervals</subject><subject>Diabetes mellitus</subject><subject>Disease</subject><subject>Diseases of the osteoarticular system</subject><subject>Estrogens</subject><subject>Fatalities</subject><subject>Fractures</subject><subject>Geriatrics</subject><subject>Hypertension</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Minerals</subject><subject>Mortality</subject><subject>Older people</subject><subject>Osteopenia</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Photon absorptiometry</subject><subject>Post-menopause</subject><subject>Radius</subject><subject>Smoking</subject><subject>Trauma</subject><subject>Women</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp9kDFv2zAQhYkiAeq4_QcZiCZDOig5kicxXAIEQtoGMJKlBbIRtHRCaUikQ8o1_O8r10a2Zrrlu_fwPsbOBVwLENUNCISi0qq6MuKrAbw1Rf2BzQRqLErULyds9oZ8ZGc5rwAAKyhnrH6KoRiT2wyODzGNrvfjjvvAqW8p9Tu-jQMFvvXjb97HLV_GQHzwgZLreUshT_gndtq5PtPn452zX98eftY_isXz98f6flE0qsSxMEhL3WhdIRpNpVIARmndyRI7CaCcEihLIwi0khKddNSSxM6IFmW7JDVnF4fcdYqvG8qjXcVNClOllaKsymmUhon68j9KGAPC6GoP4QFqUsw5UWfXyQ8u7awAu3dq98LsXpg1wv5zauvp7fKY7XLj-i650Pj89osGpyHVhN0dMJps_PGUbG48hYZan6gZbRv9-z1_AQKRh-E</recordid><startdate>19910810</startdate><enddate>19910810</enddate><creator>Browner, W.S.</creator><creator>Seeley, D.G.</creator><creator>Cummings, S.R.</creator><creator>Vogt, T.M.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19910810</creationdate><title>Non-trauma mortality in elderly women with low bone mineral density</title><author>Browner, W.S. ; Seeley, D.G. ; Cummings, S.R. ; Vogt, T.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-94eb7c7764497e533009377f254f2003a3142591e073224a2aede24f91d42dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Absorptiometry</topic><topic>Biocompatibility</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Bone density</topic><topic>Bone mineral density</topic><topic>Bones</topic><topic>Confidence intervals</topic><topic>Diabetes mellitus</topic><topic>Disease</topic><topic>Diseases of the osteoarticular system</topic><topic>Estrogens</topic><topic>Fatalities</topic><topic>Fractures</topic><topic>Geriatrics</topic><topic>Hypertension</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Minerals</topic><topic>Mortality</topic><topic>Older people</topic><topic>Osteopenia</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Photon absorptiometry</topic><topic>Post-menopause</topic><topic>Radius</topic><topic>Smoking</topic><topic>Trauma</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Browner, W.S.</creatorcontrib><creatorcontrib>Seeley, D.G.</creatorcontrib><creatorcontrib>Cummings, S.R.</creatorcontrib><creatorcontrib>Vogt, T.M.</creatorcontrib><creatorcontrib>For The Study Of Osteoporotic Fractures Research Group</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Browner, W.S.</au><au>Seeley, D.G.</au><au>Cummings, S.R.</au><au>Vogt, T.M.</au><aucorp>For The Study Of Osteoporotic Fractures Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-trauma mortality in elderly women with low bone mineral density</atitle><jtitle>The Lancet (British edition)</jtitle><date>1991-08-10</date><risdate>1991</risdate><volume>338</volume><issue>8763</issue><spage>355</spage><epage>358</epage><pages>355-358</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>9704 ambulatory women aged 65 years or older were prospectively studied to determine whether low bone mineral density (osteopenia) was associated with mortality. Bone mineral density was measured at entry to the study by single-photon absorptiometry. 299 women died during a mean of 2·8 years' follow-up. Osteopenia was associated with increased non-trauma mortality, probably because it is a marker for several other adverse factors. Each standard deviation decrease in proximal radius bone mineral density (0·104 g/cm2) was associated with a 1·19-fold increase in mortality (95% confidence interval 1·04-1·36), adjusted for age and duration of follow-up. Diminished bone mineral density at the proximal radius was strongly associated with deaths from stroke (relative risk=1·74; 95% Cl 1·2-2·70), an association that was not confounded by history of previous stroke, hypertension, postmenopausal use of oestrogen, thiazide diuretic treatment, diabetes mellitus, and smoking. 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| ispartof | The Lancet (British edition), 1991-08, Vol.338 (8763), p.355-358 |
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| subjects | Absorptiometry Biocompatibility Biological and medical sciences Biomedical materials Bone density Bone mineral density Bones Confidence intervals Diabetes mellitus Disease Diseases of the osteoarticular system Estrogens Fatalities Fractures Geriatrics Hypertension Medical research Medical sciences Minerals Mortality Older people Osteopenia Osteoporosis. Osteomalacia. Paget disease Photon absorptiometry Post-menopause Radius Smoking Trauma Women |
| title | Non-trauma mortality in elderly women with low bone mineral density |
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