DISCRIMINANT FUNCTION BASED ON STEROID ABNORMALITIES IN PATIENTS WITH LUNG CANCER
The urinary excretion of androsterone. ætiocholanolone, dehydroepiandrosterone, total 17-oxosteroids, and total 17-hydroxy-corticosteroids (17-OHc.s.) was measured in two or three consecutive early-morning specimens of urine from one hundred and forty-two lung-cancer patients, fifty-two inpatient co...
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| Veröffentlicht in: | The Lancet (British edition) 1970-08, Vol.296 (7670), p.441-445 |
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| creator | Rao, L.G.S. |
| description | The urinary excretion of androsterone. ætiocholanolone, dehydroepiandrosterone, total 17-oxosteroids, and total 17-hydroxy-corticosteroids (17-OHc.s.) was measured in two or three consecutive early-morning specimens of urine from one hundred and forty-two lung-cancer patients, fifty-two inpatient controls, and a hundred healthy controls. Patients with lung cancer have low androsterone/ætiocholanolone ratios and high 17-OHc.s./ androsterone ratios compared with controls. When the steroid values are combined in a discriminant function the error of misclassification is less than 10%. The low androsterone/ætiocholanolone ratio does not change after the surgical removal of the tumour. The discriminant function is lower in patients with inoperable tumours than in patients with operable tumours and may, therefore, be of diagnostic or prognostic value. |
| doi_str_mv | 10.1016/S0140-6736(70)90057-7 |
| format | Article |
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Patients with lung cancer have low androsterone/ætiocholanolone ratios and high 17-OHc.s./ androsterone ratios compared with controls. When the steroid values are combined in a discriminant function the error of misclassification is less than 10%. The low androsterone/ætiocholanolone ratio does not change after the surgical removal of the tumour. The discriminant function is lower in patients with inoperable tumours than in patients with operable tumours and may, therefore, be of diagnostic or prognostic value.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(70)90057-7</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Abnormalities ; Cancer ; Corticoids ; Corticosteroids ; Dehydroepiandrosterone ; Diagnostic systems ; Discriminant analysis ; Excretion ; Lung cancer ; Patients ; Steroids ; Tumors ; Urine</subject><ispartof>The Lancet (British edition), 1970-08, Vol.296 (7670), p.441-445</ispartof><rights>1970</rights><rights>Copyright Elsevier Limited Aug 29, 1970</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-c613e7457daf8ef4a830a124a17a707468e4d8d6916fdc4a061dc804084cac8e3</citedby><cites>FETCH-LOGICAL-c250t-c613e7457daf8ef4a830a124a17a707468e4d8d6916fdc4a061dc804084cac8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0140-6736(70)90057-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Rao, L.G.S.</creatorcontrib><title>DISCRIMINANT FUNCTION BASED ON STEROID ABNORMALITIES IN PATIENTS WITH LUNG CANCER</title><title>The Lancet (British edition)</title><description>The urinary excretion of androsterone. ætiocholanolone, dehydroepiandrosterone, total 17-oxosteroids, and total 17-hydroxy-corticosteroids (17-OHc.s.) was measured in two or three consecutive early-morning specimens of urine from one hundred and forty-two lung-cancer patients, fifty-two inpatient controls, and a hundred healthy controls. Patients with lung cancer have low androsterone/ætiocholanolone ratios and high 17-OHc.s./ androsterone ratios compared with controls. When the steroid values are combined in a discriminant function the error of misclassification is less than 10%. The low androsterone/ætiocholanolone ratio does not change after the surgical removal of the tumour. The discriminant function is lower in patients with inoperable tumours than in patients with operable tumours and may, therefore, be of diagnostic or prognostic value.</description><subject>Abnormalities</subject><subject>Cancer</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Dehydroepiandrosterone</subject><subject>Diagnostic systems</subject><subject>Discriminant analysis</subject><subject>Excretion</subject><subject>Lung cancer</subject><subject>Patients</subject><subject>Steroids</subject><subject>Tumors</subject><subject>Urine</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKw0AUhgdRsFYfQRhwo4vomWYu6UpimrYD6USTFN0Nw2QCKdrUpBV8e9NW3Lo6_-K_cD6ErgncEyD8IQdCwePC57cC7sYATHjiBA0IFdRjVLydosGf5RxddN0KACgHNkAvE5lHmVxIFaoCT5cqKmSq8FOYxxPci7yIs1ROcPik0mwRJrKQcY6lws9hr1SR41dZzHGyVDMchSqKs0t0Vpn3zl393iFaTuMimntJOpNRmHh2xGDrWU58JygTpakCV1ET-GDIiBoijABBeeBoGZR8THhVWmqAk9IGQCGg1tjA-UN0c-zdtM3nznVbvWp27bqf1CPCOA3GnInexY4u2zZd17pKb9r6w7TfmoDe09MHenqPRgvQB3p6n3s85lz_wlftWt3Z2q2tK-vW2a0um_qfhh-pvG6a</recordid><startdate>19700829</startdate><enddate>19700829</enddate><creator>Rao, L.G.S.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19700829</creationdate><title>DISCRIMINANT FUNCTION BASED ON STEROID ABNORMALITIES IN PATIENTS WITH LUNG CANCER</title><author>Rao, L.G.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-c613e7457daf8ef4a830a124a17a707468e4d8d6916fdc4a061dc804084cac8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Abnormalities</topic><topic>Cancer</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Dehydroepiandrosterone</topic><topic>Diagnostic systems</topic><topic>Discriminant analysis</topic><topic>Excretion</topic><topic>Lung cancer</topic><topic>Patients</topic><topic>Steroids</topic><topic>Tumors</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, L.G.S.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, L.G.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DISCRIMINANT FUNCTION BASED ON STEROID ABNORMALITIES IN PATIENTS WITH LUNG CANCER</atitle><jtitle>The Lancet (British edition)</jtitle><date>1970-08-29</date><risdate>1970</risdate><volume>296</volume><issue>7670</issue><spage>441</spage><epage>445</epage><pages>441-445</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>The urinary excretion of androsterone. ætiocholanolone, dehydroepiandrosterone, total 17-oxosteroids, and total 17-hydroxy-corticosteroids (17-OHc.s.) was measured in two or three consecutive early-morning specimens of urine from one hundred and forty-two lung-cancer patients, fifty-two inpatient controls, and a hundred healthy controls. Patients with lung cancer have low androsterone/ætiocholanolone ratios and high 17-OHc.s./ androsterone ratios compared with controls. When the steroid values are combined in a discriminant function the error of misclassification is less than 10%. The low androsterone/ætiocholanolone ratio does not change after the surgical removal of the tumour. The discriminant function is lower in patients with inoperable tumours than in patients with operable tumours and may, therefore, be of diagnostic or prognostic value.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0140-6736(70)90057-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1970-08, Vol.296 (7670), p.441-445 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Abnormalities Cancer Corticoids Corticosteroids Dehydroepiandrosterone Diagnostic systems Discriminant analysis Excretion Lung cancer Patients Steroids Tumors Urine |
| title | DISCRIMINANT FUNCTION BASED ON STEROID ABNORMALITIES IN PATIENTS WITH LUNG CANCER |
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