EFFECT OF CIMETIDINE ON GASTRIC JUICE N-NITROSAMINE CONCENTRATION
Total extractable N-nitroso compounds, pH, and nitrite levels were measured in, and microorganisms were cultured from, the fasting gastric juice of 140 patients taking the H2-receptor antagonist cimetidine and from 267 subjects, including 50 healthy volunteers, not taking cimetidine. Significantly h...
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| Veröffentlicht in: | The Lancet (British edition) 1981-09, Vol.318 (8246), p.553-556 |
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| creator | Reed, P.I. Haines, K. Smith, P.L.R. House, F.R. Walters, C.L. |
| description | Total extractable N-nitroso compounds, pH, and nitrite levels were measured in, and microorganisms were cultured from, the fasting gastric juice of 140 patients taking the H2-receptor antagonist cimetidine and from 267 subjects, including 50 healthy volunteers, not taking cimetidine. Significantly higher mean N-nitrosamine concentrations and pH levels were demonstrated in the cimetidine-treated patients; N-nitrosamine concentration increased with pH. In 30 patients studied, cimetidine treatment significantly increased gastric pH and N-nitrosamine concentrations, while in 23 patients withdrawal of cimetidine treatment resulted in a significant reduction of pH but not of N-nitrosamine concentrations. The gastric juice nitrite level was often raised and nitrate-reducing bacteria cultured were similar to those associated with other causes of hypochlorhydria. These results demonstrate for the first time a relation between gastric juice N-nitrosamine concentration, pH, and cimetidine treatment, and the findings are discussed in relation to gastric cancer induction. |
| doi_str_mv | 10.1016/S0140-6736(81)90940-5 |
| format | Article |
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Significantly higher mean N-nitrosamine concentrations and pH levels were demonstrated in the cimetidine-treated patients; N-nitrosamine concentration increased with pH. In 30 patients studied, cimetidine treatment significantly increased gastric pH and N-nitrosamine concentrations, while in 23 patients withdrawal of cimetidine treatment resulted in a significant reduction of pH but not of N-nitrosamine concentrations. The gastric juice nitrite level was often raised and nitrate-reducing bacteria cultured were similar to those associated with other causes of hypochlorhydria. 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These results demonstrate for the first time a relation between gastric juice N-nitrosamine concentration, pH, and cimetidine treatment, and the findings are discussed in relation to gastric cancer induction.</description><subject>Bacteria</subject><subject>Cimetidine</subject><subject>Denitrifying bacteria</subject><subject>Drug dosages</subject><subject>Drug withdrawal</subject><subject>Endoscopy</subject><subject>Gastric cancer</subject><subject>Gastric juice</subject><subject>Juices</subject><subject>Microorganisms</subject><subject>N-Nitroso compounds</subject><subject>Nitrosamine</subject><subject>Nitroso compounds</subject><subject>Patients</subject><subject>pH effects</subject><subject>Tumors</subject><subject>Ulcers</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><recordid>eNqFkM9LwzAUx4MoOKd_glDwoodq0iZpcpKSpTOytbB14C2kaQodus50E_zv7Tbx6unx-P54vA8Atwg-Iojo0xIiDEOaxPSeoQcO-bCRMzBCOMEhwcnbORj9WS7BVd-vIYSYQjICqcwyKcqgyAKh5rJUE5XLoMiDabosF0oEryslZJCHuSoXxTKdH2RR5ELm5SItVZFfg4vGvPfu5neOwSqTpXgJZ8VUiXQW2ojAXWg5ochwm0S4drGtamI5ZZxwZ1yFYsvqyCSoxtYgSJpoEKBlxsQVcwzzqonH4O7Uu_Xd5971O73u9n4znNQRIhSzCKJocJGTy_qu771r9Na3H8Z_awT1gZY-0tIHFJohfaSlyZB7PuXc8MJX67zubes21tWtd3an6679p-EHSmVqog</recordid><startdate>19810912</startdate><enddate>19810912</enddate><creator>Reed, P.I.</creator><creator>Haines, K.</creator><creator>Smith, P.L.R.</creator><creator>House, F.R.</creator><creator>Walters, C.L.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19810912</creationdate><title>EFFECT OF CIMETIDINE ON GASTRIC JUICE N-NITROSAMINE CONCENTRATION</title><author>Reed, P.I. ; Haines, K. ; Smith, P.L.R. ; House, F.R. ; Walters, C.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-c9561a9c724de3cbd5c968959eaeb13c8d2a71d4ca105f29590c8aa3b8e849bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Bacteria</topic><topic>Cimetidine</topic><topic>Denitrifying bacteria</topic><topic>Drug dosages</topic><topic>Drug withdrawal</topic><topic>Endoscopy</topic><topic>Gastric cancer</topic><topic>Gastric juice</topic><topic>Juices</topic><topic>Microorganisms</topic><topic>N-Nitroso compounds</topic><topic>Nitrosamine</topic><topic>Nitroso compounds</topic><topic>Patients</topic><topic>pH effects</topic><topic>Tumors</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reed, P.I.</creatorcontrib><creatorcontrib>Haines, K.</creatorcontrib><creatorcontrib>Smith, P.L.R.</creatorcontrib><creatorcontrib>House, F.R.</creatorcontrib><creatorcontrib>Walters, C.L.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reed, P.I.</au><au>Haines, K.</au><au>Smith, P.L.R.</au><au>House, F.R.</au><au>Walters, C.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF CIMETIDINE ON GASTRIC JUICE N-NITROSAMINE CONCENTRATION</atitle><jtitle>The Lancet (British edition)</jtitle><date>1981-09-12</date><risdate>1981</risdate><volume>318</volume><issue>8246</issue><spage>553</spage><epage>556</epage><pages>553-556</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>Total extractable N-nitroso compounds, pH, and nitrite levels were measured in, and microorganisms were cultured from, the fasting gastric juice of 140 patients taking the H2-receptor antagonist cimetidine and from 267 subjects, including 50 healthy volunteers, not taking cimetidine. 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| ispartof | The Lancet (British edition), 1981-09, Vol.318 (8246), p.553-556 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Bacteria Cimetidine Denitrifying bacteria Drug dosages Drug withdrawal Endoscopy Gastric cancer Gastric juice Juices Microorganisms N-Nitroso compounds Nitrosamine Nitroso compounds Patients pH effects Tumors Ulcers |
| title | EFFECT OF CIMETIDINE ON GASTRIC JUICE N-NITROSAMINE CONCENTRATION |
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