HPV 16 DNA IN NORMAL AND MALIGNANT CERVICAL EPITHELIUM: IMPLICATIONS FOR THE AETIOLOGY AND BEHAVIOUR OF CERVICAL NEOPLASIA

Southern blot hybridisation showed that cervical cancer biopsy specimens from 31 of 47 (66%, 95% confidence interval [CI] 52-80%) patients contained HPV 16 homologous DNA sequences, with evidence of integration of viral genome into host cell chromosomes in 7. Normal ectocervical biopsies from 9 of 2...

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Veröffentlicht in:	The Lancet (British edition) 1987-03, Vol.329 (8535), p.703-707
Hauptverfasser:	Meanwell, CliveA, Blackledge, George, Cox, MartynF, Maitland, NormanJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Biopsy Cervical cancer Cervix Chromosomes Confidence intervals Contraceptives Deoxyribonucleic acid DNA Epithelium Etiology Gene sequencing Genomes Homology Human papillomavirus Hybridization Integration Nucleotide sequence Oral contraceptives Smoking
Online-Zugang:	Volltext
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