Tretinoin toxicity in children with acute promyelocytic leukaemia
Tretinoin is effective in acute promyelocytic leukaemia in adults. Data about its efficacy and safety in children are limited. We have treated 9 children with tretinoin at 45 mg/m2 per day. Pseudotumour cerebri or hyperleucocytosis occured in 5 patients. Retinoic acid syndrome was seen in 3 cases. 1...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 1993-12, Vol.342 (8884), p.1394-1395 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1395 |
|---|---|
| container_issue | 8884 |
| container_start_page | 1394 |
| container_title | The Lancet (British edition) |
| container_volume | 342 |
| creator | Mahmoud, H.H. Hurwitz, C.A. Roberts, W.M. Santana, V.M. Ribeiro, R.C. Krance, R.A. |
| description | Tretinoin is effective in acute promyelocytic leukaemia in adults. Data about its efficacy and safety in children are limited. We have treated 9 children with tretinoin at 45 mg/m2 per day. Pseudotumour cerebri or hyperleucocytosis occured in 5 patients. Retinoic acid syndrome was seen in 3 cases. 1 of 2 children who developed hyperleucocytosis, pseudotumour cerebri, and retinoic acid syndrome died despite steroids and mechanical ventilation. Complete remissions with tretinoin alone were achieved in 5 patients. All 8 surviving children received consolidation chemotherapy. Our experience with tretinoin therapy suggests that toxixity is frequent in children. Lancet 1993; 342: 1394–95 |
| doi_str_mv | 10.1016/0140-6736(93)92755-I |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2156475944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>014067369392755I</els_id><sourcerecordid>2156475944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-426705d36f4b7cda38bb2912d746619f4a4af774112ca3eb290cd434800a45713</originalsourceid><addsrcrecordid>eNp9kE9LwzAYh4Moc06_gUJRD3qoJs3bZLkIY_hnMPAywVvI0pRldq0mqdpvb-bGbnpK4Pe8v7x5EDol-IZgwm4xAZwyTtmVoNci43meTvZQnwCHNAf-uo_6O-QQHXm_xBgDw3kP9biIDUPoo9HMmWDrxtZJaL6ttqFL4l0vbFU4UydfNiwSpdtgknfXrDpTNboLVieVad-UWVl1jA5KVXlzsj0H6OXhfjZ-SqfPj5PxaJpqEFlIIWMc5wVlJcy5LhQdzueZIFnBgTEiSlCgSs6BkEwramKGdQEUhhgryDmhA3Sx6Y17fLTGB7lsWlfHJ2VGcgY8FwCROv-LIiJ-GgjHEYINpF3jvTOlfHd2pVwnCZZrt3ItTq7FSUHlr1s5iWNn2-52vjLFbmgrM-aX21x5rarSqVpbv8PokAEVPGJ3G8xEW5_WOOm1NbU2hXVGB1k09v89fgC7UJNh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199014170</pqid></control><display><type>article</type><title>Tretinoin toxicity in children with acute promyelocytic leukaemia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Business Source Complete</source><creator>Mahmoud, H.H. ; Hurwitz, C.A. ; Roberts, W.M. ; Santana, V.M. ; Ribeiro, R.C. ; Krance, R.A.</creator><creatorcontrib>Mahmoud, H.H. ; Hurwitz, C.A. ; Roberts, W.M. ; Santana, V.M. ; Ribeiro, R.C. ; Krance, R.A.</creatorcontrib><description>Tretinoin is effective in acute promyelocytic leukaemia in adults. Data about its efficacy and safety in children are limited. We have treated 9 children with tretinoin at 45 mg/m2 per day. Pseudotumour cerebri or hyperleucocytosis occured in 5 patients. Retinoic acid syndrome was seen in 3 cases. 1 of 2 children who developed hyperleucocytosis, pseudotumour cerebri, and retinoic acid syndrome died despite steroids and mechanical ventilation. Complete remissions with tretinoin alone were achieved in 5 patients. All 8 surviving children received consolidation chemotherapy. Our experience with tretinoin therapy suggests that toxixity is frequent in children. Lancet 1993; 342: 1394–95</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(93)92755-I</identifier><identifier>PMID: 7901684</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adolescent ; Adults ; Biological and medical sciences ; Chemotherapy ; Child ; Child, Preschool ; Children ; Drug therapy ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Infant ; Leukemia ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukocyte Count - drug effects ; Leukocytes - physiology ; Male ; Mechanical ventilation ; Medical research ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Patients ; Pediatrics ; Pharmacology. Drug treatments ; Pseudotumor Cerebri - chemically induced ; Pseudotumors ; Retinoic acid ; Steroid hormones ; Steroids ; Syndrome ; Toxicity ; Tretinoin ; Tretinoin - adverse effects ; Tretinoin - therapeutic use ; Ventilation</subject><ispartof>The Lancet (British edition), 1993-12, Vol.342 (8884), p.1394-1395</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Dec 4, 1993</rights><rights>Copyright Elsevier Limited Dec 4, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-426705d36f4b7cda38bb2912d746619f4a4af774112ca3eb290cd434800a45713</citedby><cites>FETCH-LOGICAL-c492t-426705d36f4b7cda38bb2912d746619f4a4af774112ca3eb290cd434800a45713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/014067369392755I$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3864397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7901684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmoud, H.H.</creatorcontrib><creatorcontrib>Hurwitz, C.A.</creatorcontrib><creatorcontrib>Roberts, W.M.</creatorcontrib><creatorcontrib>Santana, V.M.</creatorcontrib><creatorcontrib>Ribeiro, R.C.</creatorcontrib><creatorcontrib>Krance, R.A.</creatorcontrib><title>Tretinoin toxicity in children with acute promyelocytic leukaemia</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Tretinoin is effective in acute promyelocytic leukaemia in adults. Data about its efficacy and safety in children are limited. We have treated 9 children with tretinoin at 45 mg/m2 per day. Pseudotumour cerebri or hyperleucocytosis occured in 5 patients. Retinoic acid syndrome was seen in 3 cases. 1 of 2 children who developed hyperleucocytosis, pseudotumour cerebri, and retinoic acid syndrome died despite steroids and mechanical ventilation. Complete remissions with tretinoin alone were achieved in 5 patients. All 8 surviving children received consolidation chemotherapy. Our experience with tretinoin therapy suggests that toxixity is frequent in children. Lancet 1993; 342: 1394–95</description><subject>Adolescent</subject><subject>Adults</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Drug therapy</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemia</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukocyte Count - drug effects</subject><subject>Leukocytes - physiology</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudotumor Cerebri - chemically induced</subject><subject>Pseudotumors</subject><subject>Retinoic acid</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Syndrome</subject><subject>Toxicity</subject><subject>Tretinoin</subject><subject>Tretinoin - adverse effects</subject><subject>Tretinoin - therapeutic use</subject><subject>Ventilation</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE9LwzAYh4Moc06_gUJRD3qoJs3bZLkIY_hnMPAywVvI0pRldq0mqdpvb-bGbnpK4Pe8v7x5EDol-IZgwm4xAZwyTtmVoNci43meTvZQnwCHNAf-uo_6O-QQHXm_xBgDw3kP9biIDUPoo9HMmWDrxtZJaL6ttqFL4l0vbFU4UydfNiwSpdtgknfXrDpTNboLVieVad-UWVl1jA5KVXlzsj0H6OXhfjZ-SqfPj5PxaJpqEFlIIWMc5wVlJcy5LhQdzueZIFnBgTEiSlCgSs6BkEwramKGdQEUhhgryDmhA3Sx6Y17fLTGB7lsWlfHJ2VGcgY8FwCROv-LIiJ-GgjHEYINpF3jvTOlfHd2pVwnCZZrt3ItTq7FSUHlr1s5iWNn2-52vjLFbmgrM-aX21x5rarSqVpbv8PokAEVPGJ3G8xEW5_WOOm1NbU2hXVGB1k09v89fgC7UJNh</recordid><startdate>19931204</startdate><enddate>19931204</enddate><creator>Mahmoud, H.H.</creator><creator>Hurwitz, C.A.</creator><creator>Roberts, W.M.</creator><creator>Santana, V.M.</creator><creator>Ribeiro, R.C.</creator><creator>Krance, R.A.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>19931204</creationdate><title>Tretinoin toxicity in children with acute promyelocytic leukaemia</title><author>Mahmoud, H.H. ; Hurwitz, C.A. ; Roberts, W.M. ; Santana, V.M. ; Ribeiro, R.C. ; Krance, R.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-426705d36f4b7cda38bb2912d746619f4a4af774112ca3eb290cd434800a45713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adults</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Drug therapy</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemia</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukocyte Count - drug effects</topic><topic>Leukocytes - physiology</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudotumor Cerebri - chemically induced</topic><topic>Pseudotumors</topic><topic>Retinoic acid</topic><topic>Steroid hormones</topic><topic>Steroids</topic><topic>Syndrome</topic><topic>Toxicity</topic><topic>Tretinoin</topic><topic>Tretinoin - adverse effects</topic><topic>Tretinoin - therapeutic use</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmoud, H.H.</creatorcontrib><creatorcontrib>Hurwitz, C.A.</creatorcontrib><creatorcontrib>Roberts, W.M.</creatorcontrib><creatorcontrib>Santana, V.M.</creatorcontrib><creatorcontrib>Ribeiro, R.C.</creatorcontrib><creatorcontrib>Krance, R.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmoud, H.H.</au><au>Hurwitz, C.A.</au><au>Roberts, W.M.</au><au>Santana, V.M.</au><au>Ribeiro, R.C.</au><au>Krance, R.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tretinoin toxicity in children with acute promyelocytic leukaemia</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1993-12-04</date><risdate>1993</risdate><volume>342</volume><issue>8884</issue><spage>1394</spage><epage>1395</epage><pages>1394-1395</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Tretinoin is effective in acute promyelocytic leukaemia in adults. Data about its efficacy and safety in children are limited. We have treated 9 children with tretinoin at 45 mg/m2 per day. Pseudotumour cerebri or hyperleucocytosis occured in 5 patients. Retinoic acid syndrome was seen in 3 cases. 1 of 2 children who developed hyperleucocytosis, pseudotumour cerebri, and retinoic acid syndrome died despite steroids and mechanical ventilation. Complete remissions with tretinoin alone were achieved in 5 patients. All 8 surviving children received consolidation chemotherapy. Our experience with tretinoin therapy suggests that toxixity is frequent in children. Lancet 1993; 342: 1394–95</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7901684</pmid><doi>10.1016/0140-6736(93)92755-I</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1993-12, Vol.342 (8884), p.1394-1395 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_journals_2156475944 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Business Source Complete |
| subjects | Adolescent Adults Biological and medical sciences Chemotherapy Child Child, Preschool Children Drug therapy Drug toxicity and drugs side effects treatment Female Humans Infant Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukocyte Count - drug effects Leukocytes - physiology Male Mechanical ventilation Medical research Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Patients Pediatrics Pharmacology. Drug treatments Pseudotumor Cerebri - chemically induced Pseudotumors Retinoic acid Steroid hormones Steroids Syndrome Toxicity Tretinoin Tretinoin - adverse effects Tretinoin - therapeutic use Ventilation |
| title | Tretinoin toxicity in children with acute promyelocytic leukaemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T10%3A57%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tretinoin%20toxicity%20in%20children%20with%20acute%20promyelocytic%20leukaemia&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Mahmoud,%20H.H.&rft.date=1993-12-04&rft.volume=342&rft.issue=8884&rft.spage=1394&rft.epage=1395&rft.pages=1394-1395&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/0140-6736(93)92755-I&rft_dat=%3Cproquest_cross%3E2156475944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199014170&rft_id=info:pmid/7901684&rft_els_id=014067369392755I&rfr_iscdi=true |