DIAGNOSIS OF TUBERCULOUS MENINGITIS BY DETECTION OF TUBERCULOSTEARIC ACID IN CEREBROSPINAL FLUID
Tuberculostearic acid, a structural component of Mycobacterium tuberculosis, was identified by gas chromatography/mass spectrometry with selected ion monitoring in cerebrospinal fluid (CSF) from 13 patients with proven and 8 out of 9 patients with suspected tuberculous meningitis; the negative resul...
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| Veröffentlicht in: | The Lancet (British edition) 1987-07, Vol.330 (8551), p.117-119 |
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| creator | French, G.L. Chan, C.Y. Cheung, S.W. Teoh, R. Humphries, M.J. O'Mahony, G. |
| description | Tuberculostearic acid, a structural component of Mycobacterium tuberculosis, was identified by gas chromatography/mass spectrometry with selected ion monitoring in cerebrospinal fluid (CSF) from 13 patients with proven and 8 out of 9 patients with suspected tuberculous meningitis; the negative result was in a patient whose symptoms and CSF abnormalities may have been due to systemic lupus erythematosus. Tuberculostearic acid was found in the CSF of only 1 patient out of 87 with non-tuberculous meningitis or non-infectious disorders; the single false-positive result was probably caused by intrathecal treatment with amikacin. Other aminoglycosides and antituberculous drugs did not interfere with the assay. In serial CSF samples from patients with tuberculous meningitis tuberculostearic acid was still present after 8 months of continuous supervised chemotherapy. Detection of tuberculostearic acid in CSF is a rapid, sensitive, and specific test for tuberculous meningitis, and can be used for retrospective diagnosis in patients who have been started on therapy. |
| doi_str_mv | 10.1016/S0140-6736(87)92328-2 |
| format | Article |
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Tuberculostearic acid was found in the CSF of only 1 patient out of 87 with non-tuberculous meningitis or non-infectious disorders; the single false-positive result was probably caused by intrathecal treatment with amikacin. Other aminoglycosides and antituberculous drugs did not interfere with the assay. In serial CSF samples from patients with tuberculous meningitis tuberculostearic acid was still present after 8 months of continuous supervised chemotherapy. Detection of tuberculostearic acid in CSF is a rapid, sensitive, and specific test for tuberculous meningitis, and can be used for retrospective diagnosis in patients who have been started on therapy.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(87)92328-2</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Abnormalities ; Acids ; Amikacin ; Aminoglycosides ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Cerebrospinal fluid ; Chemotherapy ; Chronic conditions ; Diagnosis ; Gas chromatography ; Human bacterial diseases ; Infectious diseases ; Mass spectrometry ; Mass spectroscopy ; Medical diagnosis ; Medical sciences ; Meningitis ; Patients ; Systemic lupus erythematosus ; Tuberculosis</subject><ispartof>The Lancet (British edition), 1987-07, Vol.330 (8551), p.117-119</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jul 18, 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-38a85b366c346f1b4ab975bf2ff1b40c79993efc7028f393407a2f765d29aac63</citedby><cites>FETCH-LOGICAL-c302t-38a85b366c346f1b4ab975bf2ff1b40c79993efc7028f393407a2f765d29aac63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673687923282$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7430134$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>French, G.L.</creatorcontrib><creatorcontrib>Chan, C.Y.</creatorcontrib><creatorcontrib>Cheung, S.W.</creatorcontrib><creatorcontrib>Teoh, R.</creatorcontrib><creatorcontrib>Humphries, M.J.</creatorcontrib><creatorcontrib>O'Mahony, G.</creatorcontrib><title>DIAGNOSIS OF TUBERCULOUS MENINGITIS BY DETECTION OF TUBERCULOSTEARIC ACID IN CEREBROSPINAL FLUID</title><title>The Lancet (British edition)</title><description>Tuberculostearic acid, a structural component of Mycobacterium tuberculosis, was identified by gas chromatography/mass spectrometry with selected ion monitoring in cerebrospinal fluid (CSF) from 13 patients with proven and 8 out of 9 patients with suspected tuberculous meningitis; the negative result was in a patient whose symptoms and CSF abnormalities may have been due to systemic lupus erythematosus. Tuberculostearic acid was found in the CSF of only 1 patient out of 87 with non-tuberculous meningitis or non-infectious disorders; the single false-positive result was probably caused by intrathecal treatment with amikacin. Other aminoglycosides and antituberculous drugs did not interfere with the assay. In serial CSF samples from patients with tuberculous meningitis tuberculostearic acid was still present after 8 months of continuous supervised chemotherapy. Detection of tuberculostearic acid in CSF is a rapid, sensitive, and specific test for tuberculous meningitis, and can be used for retrospective diagnosis in patients who have been started on therapy.</description><subject>Abnormalities</subject><subject>Acids</subject><subject>Amikacin</subject><subject>Aminoglycosides</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid</subject><subject>Chemotherapy</subject><subject>Chronic conditions</subject><subject>Diagnosis</subject><subject>Gas chromatography</subject><subject>Human bacterial diseases</subject><subject>Infectious diseases</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Meningitis</subject><subject>Patients</subject><subject>Systemic lupus erythematosus</subject><subject>Tuberculosis</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqFkF9LwzAUxYMoOKcfQSjogz5U869J-yRd181AbWVtQZ9iliVQ0U2TKfjt7ZwMfPLpcrm_cw73AHCK4BWCiF3XEFEYMk7YRcwvE0xwHOI9MECU0zCi_GEfDHbIITjy_hlCSBmMBuBpLNJpWdWiDqpJ0LSjfJa1RdXWwV1einIqmv4yegzGeZNnjajKP1jd5OlMZEGaiXEgyiDLZ_loVtX3okyLYFK0YnwMDqx68ebkdw5BO8mb7DYsqqnI0iLUBOJ1SGIVR3PCmCaUWTSnap7waG6x3SxQ8yRJiLGaQxxbkhAKucKWs2iBE6U0I0NwtvV9c6v3D-PX8nn14ZZ9pMQoYjQijPKeiraUdivvnbHyzXWvyn1JBOWmTPlTptw0JWMuf8qUuNed_7orr9WLdWqpO78Tc0ogIrTHbraY6T_97IyTXndmqc2ic0av5WLV_RP0DdaOf0Q</recordid><startdate>19870718</startdate><enddate>19870718</enddate><creator>French, G.L.</creator><creator>Chan, C.Y.</creator><creator>Cheung, S.W.</creator><creator>Teoh, R.</creator><creator>Humphries, M.J.</creator><creator>O'Mahony, G.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19870718</creationdate><title>DIAGNOSIS OF TUBERCULOUS MENINGITIS BY DETECTION OF TUBERCULOSTEARIC ACID IN CEREBROSPINAL FLUID</title><author>French, G.L. ; Chan, C.Y. ; Cheung, S.W. ; Teoh, R. ; Humphries, M.J. ; O'Mahony, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-38a85b366c346f1b4ab975bf2ff1b40c79993efc7028f393407a2f765d29aac63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Abnormalities</topic><topic>Acids</topic><topic>Amikacin</topic><topic>Aminoglycosides</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid</topic><topic>Chemotherapy</topic><topic>Chronic conditions</topic><topic>Diagnosis</topic><topic>Gas chromatography</topic><topic>Human bacterial diseases</topic><topic>Infectious diseases</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Meningitis</topic><topic>Patients</topic><topic>Systemic lupus erythematosus</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>French, G.L.</creatorcontrib><creatorcontrib>Chan, C.Y.</creatorcontrib><creatorcontrib>Cheung, S.W.</creatorcontrib><creatorcontrib>Teoh, R.</creatorcontrib><creatorcontrib>Humphries, M.J.</creatorcontrib><creatorcontrib>O'Mahony, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>French, G.L.</au><au>Chan, C.Y.</au><au>Cheung, S.W.</au><au>Teoh, R.</au><au>Humphries, M.J.</au><au>O'Mahony, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DIAGNOSIS OF TUBERCULOUS MENINGITIS BY DETECTION OF TUBERCULOSTEARIC ACID IN CEREBROSPINAL FLUID</atitle><jtitle>The Lancet (British edition)</jtitle><date>1987-07-18</date><risdate>1987</risdate><volume>330</volume><issue>8551</issue><spage>117</spage><epage>119</epage><pages>117-119</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Tuberculostearic acid, a structural component of Mycobacterium tuberculosis, was identified by gas chromatography/mass spectrometry with selected ion monitoring in cerebrospinal fluid (CSF) from 13 patients with proven and 8 out of 9 patients with suspected tuberculous meningitis; the negative result was in a patient whose symptoms and CSF abnormalities may have been due to systemic lupus erythematosus. 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| subjects | Abnormalities Acids Amikacin Aminoglycosides Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Cerebrospinal fluid Chemotherapy Chronic conditions Diagnosis Gas chromatography Human bacterial diseases Infectious diseases Mass spectrometry Mass spectroscopy Medical diagnosis Medical sciences Meningitis Patients Systemic lupus erythematosus Tuberculosis |
| title | DIAGNOSIS OF TUBERCULOUS MENINGITIS BY DETECTION OF TUBERCULOSTEARIC ACID IN CEREBROSPINAL FLUID |
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