Homocysteine and vitamin status in healthy Thai smokers
Purpose. Cigarette smoking is considered to increase morbidity and the mortality risk of cardiovascular diseases. B vitamins regulate the metabolism of homocysteine via remethylation and trans-sulfuration pathways. The purpose of this study was to investigate homocysteine concentrations, vitamin sta...
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Veröffentlicht in: | Journal of nutritional and environmental medicine 2005-01, Vol.15 (1), p.9-21 |
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creator | Suriyaprom, K Tungtrongchitr, R Pongpaew, P Phonrat, B Harnroongroj, T Vudhivai, N Tungtrongchitr, A Paksanont, S Pooudong, S Schelp, F.P |
description | Purpose. Cigarette smoking is considered to increase morbidity and the mortality risk of cardiovascular diseases. B vitamins regulate the metabolism of homocysteine via remethylation and trans-sulfuration pathways. The purpose of this study was to investigate homocysteine concentrations, vitamin status, anthropometric and haematological measurements of healthy smokers compared with healthy non-smoking subjects. Design. This cross-sectional study was carried out among smokers and non-smokers from suburban and urban residential areas in Bangkok, Thailand. Materials and methods. 174 smokers and 97 non-smokers (aged 19-62), who participated voluntarily in the study, were investigated. Total homocysteine, folate, vitamin B2, B6, B12, and C concentrations were measured. Results. Total homocysteine concentrations in plasma were significantly higher in smokers than non-smokers. Vitamin B2, folate, B12 and C concentrations were significantly lower among smokers than non-smokers but vitamin B6 was not significantly different between these groups. Total homocysteine concentration had a significantly positive correlation with waist/hip ratio and smoking characteristics such as the number of cigarettes per day and pack-years but a significantly negative association with folate and vitamin B12. There were significant positive associations among the number of cigarettes smoked per day, white blood cell (WBC) count and waist/hip ratio. Furthermore, the prevalence of hyperhomocysteinemia in smokers (62%) was more common than in non-smokers (33%). Conclusion. These findings suggest that increased plasma total homocysteine concentrations in healthy Thai smokers may be explained by a low status of the B vitamins that are involved in homocysteine metabolism such as vitamin B2, folate, and B12. The elevation of the number of cigarettes smoked per day and pack-years, WBC count, and high percentage of hyperhomocysteinemia among smokers may contribute to increased risk of atherosclerosis or the development of cardiovascular disease. |
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Cigarette smoking is considered to increase morbidity and the mortality risk of cardiovascular diseases. B vitamins regulate the metabolism of homocysteine via remethylation and trans-sulfuration pathways. The purpose of this study was to investigate homocysteine concentrations, vitamin status, anthropometric and haematological measurements of healthy smokers compared with healthy non-smoking subjects. Design. This cross-sectional study was carried out among smokers and non-smokers from suburban and urban residential areas in Bangkok, Thailand. Materials and methods. 174 smokers and 97 non-smokers (aged 19-62), who participated voluntarily in the study, were investigated. Total homocysteine, folate, vitamin B2, B6, B12, and C concentrations were measured. Results. Total homocysteine concentrations in plasma were significantly higher in smokers than non-smokers. Vitamin B2, folate, B12 and C concentrations were significantly lower among smokers than non-smokers but vitamin B6 was not significantly different between these groups. Total homocysteine concentration had a significantly positive correlation with waist/hip ratio and smoking characteristics such as the number of cigarettes per day and pack-years but a significantly negative association with folate and vitamin B12. There were significant positive associations among the number of cigarettes smoked per day, white blood cell (WBC) count and waist/hip ratio. Furthermore, the prevalence of hyperhomocysteinemia in smokers (62%) was more common than in non-smokers (33%). Conclusion. These findings suggest that increased plasma total homocysteine concentrations in healthy Thai smokers may be explained by a low status of the B vitamins that are involved in homocysteine metabolism such as vitamin B2, folate, and B12. The elevation of the number of cigarettes smoked per day and pack-years, WBC count, and high percentage of hyperhomocysteinemia among smokers may contribute to increased risk of atherosclerosis or the development of cardiovascular disease.</description><identifier>ISSN: 1359-0847</identifier><identifier>EISSN: 1364-6907</identifier><identifier>DOI: 10.1080/13590840500220197</identifier><identifier>CODEN: JNEMFF</identifier><language>eng</language><publisher>Abingdon: Informa UK Ltd</publisher><subject>anthropometry ; Antioxidants ; Comparative studies ; haematological indices ; health status ; Homocysteine ; hyperhomocysteinemia ; leukocyte count ; lifestyle ; middle-aged adults ; nutritional status ; smokers ; Smoking ; smoking (habit) ; Vitamin B ; vitamin B complex ; vitamin status ; young adults</subject><ispartof>Journal of nutritional and environmental medicine, 2005-01, Vol.15 (1), p.9-21</ispartof><rights>Informa UK Ltd All rights reserved: reproduction in whole or part not permitted</rights><rights>Copyright Carfax Publishing Company Mar 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-f28b36722708e5b5d595c56a70b9c4a8229f4977bde9de7c19e3c195f6fa7e193</citedby><cites>FETCH-LOGICAL-c347t-f28b36722708e5b5d595c56a70b9c4a8229f4977bde9de7c19e3c195f6fa7e193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13590840500220197$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13590840500220197$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436,61221,61402</link.rule.ids></links><search><creatorcontrib>Suriyaprom, K</creatorcontrib><creatorcontrib>Tungtrongchitr, R</creatorcontrib><creatorcontrib>Pongpaew, P</creatorcontrib><creatorcontrib>Phonrat, B</creatorcontrib><creatorcontrib>Harnroongroj, T</creatorcontrib><creatorcontrib>Vudhivai, N</creatorcontrib><creatorcontrib>Tungtrongchitr, A</creatorcontrib><creatorcontrib>Paksanont, S</creatorcontrib><creatorcontrib>Pooudong, S</creatorcontrib><creatorcontrib>Schelp, F.P</creatorcontrib><title>Homocysteine and vitamin status in healthy Thai smokers</title><title>Journal of nutritional and environmental medicine</title><description>Purpose. Cigarette smoking is considered to increase morbidity and the mortality risk of cardiovascular diseases. B vitamins regulate the metabolism of homocysteine via remethylation and trans-sulfuration pathways. The purpose of this study was to investigate homocysteine concentrations, vitamin status, anthropometric and haematological measurements of healthy smokers compared with healthy non-smoking subjects. Design. This cross-sectional study was carried out among smokers and non-smokers from suburban and urban residential areas in Bangkok, Thailand. Materials and methods. 174 smokers and 97 non-smokers (aged 19-62), who participated voluntarily in the study, were investigated. Total homocysteine, folate, vitamin B2, B6, B12, and C concentrations were measured. Results. Total homocysteine concentrations in plasma were significantly higher in smokers than non-smokers. Vitamin B2, folate, B12 and C concentrations were significantly lower among smokers than non-smokers but vitamin B6 was not significantly different between these groups. Total homocysteine concentration had a significantly positive correlation with waist/hip ratio and smoking characteristics such as the number of cigarettes per day and pack-years but a significantly negative association with folate and vitamin B12. There were significant positive associations among the number of cigarettes smoked per day, white blood cell (WBC) count and waist/hip ratio. Furthermore, the prevalence of hyperhomocysteinemia in smokers (62%) was more common than in non-smokers (33%). Conclusion. These findings suggest that increased plasma total homocysteine concentrations in healthy Thai smokers may be explained by a low status of the B vitamins that are involved in homocysteine metabolism such as vitamin B2, folate, and B12. The elevation of the number of cigarettes smoked per day and pack-years, WBC count, and high percentage of hyperhomocysteinemia among smokers may contribute to increased risk of atherosclerosis or the development of cardiovascular disease.</description><subject>anthropometry</subject><subject>Antioxidants</subject><subject>Comparative studies</subject><subject>haematological indices</subject><subject>health status</subject><subject>Homocysteine</subject><subject>hyperhomocysteinemia</subject><subject>leukocyte count</subject><subject>lifestyle</subject><subject>middle-aged adults</subject><subject>nutritional status</subject><subject>smokers</subject><subject>Smoking</subject><subject>smoking (habit)</subject><subject>Vitamin B</subject><subject>vitamin B complex</subject><subject>vitamin status</subject><subject>young adults</subject><issn>1359-0847</issn><issn>1364-6907</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kM9LwzAUx4soOKd_gCeLB2_V_GiSBr3IUCcIHtzO4S1NXGfbzKRV9t-bUUFU2CXvwft88h7fJDnF6BKjAl1hyiQqcsQQIgRhKfaSEaY8z7hEYn_bM5lFQBwmRyGsUMQwJaNETF3j9CZ0pmpNCm2ZflQdNFWbhg66PqSxWxqou-UmnS2hSkPj3owPx8mBhTqYk-86Tub3d7PJNHt6fnic3D5lmuaiyywpFpQLQgQqDFuwkkmmGQeBFlLnUBAibS6FWJRGlkZoLA2ND7PcgjBY0nFyMfy79u69N6FTTRW0qWtojeuDwoIzhnISwfM_4Mr1vo23KYIZJ4TjPEJ4gLR3IXhj1dpXDfiNwkhtc1T_cozOzeBUrXW-gU_n61J1sKmdtx5aXQVFd-nXv_QhTA3e_By4yz4bbAtOwauPu-YvcUQRRrkgktMvct2SGg</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Suriyaprom, K</creator><creator>Tungtrongchitr, R</creator><creator>Pongpaew, P</creator><creator>Phonrat, B</creator><creator>Harnroongroj, T</creator><creator>Vudhivai, N</creator><creator>Tungtrongchitr, A</creator><creator>Paksanont, S</creator><creator>Pooudong, S</creator><creator>Schelp, F.P</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20050101</creationdate><title>Homocysteine and vitamin status in healthy Thai smokers</title><author>Suriyaprom, K ; Tungtrongchitr, R ; Pongpaew, P ; Phonrat, B ; Harnroongroj, T ; Vudhivai, N ; Tungtrongchitr, A ; Paksanont, S ; Pooudong, S ; Schelp, F.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-f28b36722708e5b5d595c56a70b9c4a8229f4977bde9de7c19e3c195f6fa7e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>anthropometry</topic><topic>Antioxidants</topic><topic>Comparative studies</topic><topic>haematological indices</topic><topic>health status</topic><topic>Homocysteine</topic><topic>hyperhomocysteinemia</topic><topic>leukocyte count</topic><topic>lifestyle</topic><topic>middle-aged adults</topic><topic>nutritional status</topic><topic>smokers</topic><topic>Smoking</topic><topic>smoking (habit)</topic><topic>Vitamin B</topic><topic>vitamin B complex</topic><topic>vitamin status</topic><topic>young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suriyaprom, K</creatorcontrib><creatorcontrib>Tungtrongchitr, R</creatorcontrib><creatorcontrib>Pongpaew, P</creatorcontrib><creatorcontrib>Phonrat, B</creatorcontrib><creatorcontrib>Harnroongroj, T</creatorcontrib><creatorcontrib>Vudhivai, N</creatorcontrib><creatorcontrib>Tungtrongchitr, A</creatorcontrib><creatorcontrib>Paksanont, S</creatorcontrib><creatorcontrib>Pooudong, S</creatorcontrib><creatorcontrib>Schelp, F.P</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of nutritional and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suriyaprom, K</au><au>Tungtrongchitr, R</au><au>Pongpaew, P</au><au>Phonrat, B</au><au>Harnroongroj, T</au><au>Vudhivai, N</au><au>Tungtrongchitr, A</au><au>Paksanont, S</au><au>Pooudong, S</au><au>Schelp, F.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine and vitamin status in healthy Thai smokers</atitle><jtitle>Journal of nutritional and environmental medicine</jtitle><date>2005-01-01</date><risdate>2005</risdate><volume>15</volume><issue>1</issue><spage>9</spage><epage>21</epage><pages>9-21</pages><issn>1359-0847</issn><eissn>1364-6907</eissn><coden>JNEMFF</coden><abstract>Purpose. Cigarette smoking is considered to increase morbidity and the mortality risk of cardiovascular diseases. B vitamins regulate the metabolism of homocysteine via remethylation and trans-sulfuration pathways. The purpose of this study was to investigate homocysteine concentrations, vitamin status, anthropometric and haematological measurements of healthy smokers compared with healthy non-smoking subjects. Design. This cross-sectional study was carried out among smokers and non-smokers from suburban and urban residential areas in Bangkok, Thailand. Materials and methods. 174 smokers and 97 non-smokers (aged 19-62), who participated voluntarily in the study, were investigated. Total homocysteine, folate, vitamin B2, B6, B12, and C concentrations were measured. Results. Total homocysteine concentrations in plasma were significantly higher in smokers than non-smokers. Vitamin B2, folate, B12 and C concentrations were significantly lower among smokers than non-smokers but vitamin B6 was not significantly different between these groups. Total homocysteine concentration had a significantly positive correlation with waist/hip ratio and smoking characteristics such as the number of cigarettes per day and pack-years but a significantly negative association with folate and vitamin B12. There were significant positive associations among the number of cigarettes smoked per day, white blood cell (WBC) count and waist/hip ratio. Furthermore, the prevalence of hyperhomocysteinemia in smokers (62%) was more common than in non-smokers (33%). Conclusion. These findings suggest that increased plasma total homocysteine concentrations in healthy Thai smokers may be explained by a low status of the B vitamins that are involved in homocysteine metabolism such as vitamin B2, folate, and B12. The elevation of the number of cigarettes smoked per day and pack-years, WBC count, and high percentage of hyperhomocysteinemia among smokers may contribute to increased risk of atherosclerosis or the development of cardiovascular disease.</abstract><cop>Abingdon</cop><pub>Informa UK Ltd</pub><doi>10.1080/13590840500220197</doi><tpages>13</tpages></addata></record> |
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subjects | anthropometry Antioxidants Comparative studies haematological indices health status Homocysteine hyperhomocysteinemia leukocyte count lifestyle middle-aged adults nutritional status smokers Smoking smoking (habit) Vitamin B vitamin B complex vitamin status young adults |
title | Homocysteine and vitamin status in healthy Thai smokers |
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