Stabilizing proteins to prevent conformational changes required for amyloid fibril formation

Amyloid fibrillation is associated with several human maladies, such as Alzheimer’s, Parkinson’s, Huntington’s diseases, prions, amyotrophic lateral sclerosis, and type 2 diabetes diseases. Gaining insights into the mechanism of amyloid fibril formation and exploring novel approaches to fibrillation...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-02, Vol.120 (2), p.2642-2656
Hauptverfasser:	Siddiqi, Mohammad Khursheed, Alam, Parvez, Malik, Sadia, Majid, Nabeela, Chaturvedi, Sumit Kumar, Rajan, Sudeepa, Ajmal, Mohd Rehan, Khan, Mohsin Vahid, Uversky, Vladimir N, Khan, Rizwan Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	amyloid Amyloidogenesis Amyotrophic lateral sclerosis Calorimetry Circular dichroism Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dichroism Differential scanning calorimetry Diseases Feasibility studies Fibrillation Fibrils Fluorescence human insulin Human serum albumin Ibuprofen Inflammation Inhibition Insulin Light scattering Nucleation Photon correlation spectroscopy Prion protein Prions Protein folding protein stability Proteins Serum albumin thioflavin T (ThT) assay Toxicity Transmission electron microscopy transmission electron microscopy (TEM)
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