EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORS ASSOCIATED WITH LACK OF RESPONSE TO ENDOCRINE THERAPY IN RECURRENT BREAST CANCER

EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORS ASSOCIATED WITH LACK OF RESPONSE TO ENDOCRINE THERAPY IN RECURRENT BREAST CANCER

Epidermal growth factor receptors (EGFR) and oestrogen receptors (ER) were analysed in 221 patients with primary operable breast cancer by means of radioligand assays. After median follow-up of 24 months (range 3-60 months), there had been recurrences in 99 patients, of whom 72 (median age 56 years,...

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Veröffentlicht in:The Lancet (British edition) 1989-01, Vol.333 (8631), p.182-185
Hauptverfasser: Nicholson, Stewart, Halcrow, P., Farndon, JohnR, Sainsbury, J.R.C., Chambers, P., Harris, AdrianL
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Breast cancer
Breasts
Cancer
Endocrine therapy
Epidermal growth factor
Epidermal growth factor receptors
Growth factor receptors
Growth factors
Gynecology. Andrology. Obstetrics
Health care
Mammary gland diseases
Medical research
Medical sciences
Patients
Receptors
Tamoxifen
Tests
Therapy
Tumors
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Zusammenfassung:Epidermal growth factor receptors (EGFR) and oestrogen receptors (ER) were analysed in 221 patients with primary operable breast cancer by means of radioligand assays. After median follow-up of 24 months (range 3-60 months), there had been recurrences in 99 patients, of whom 72 (median age 56 years, range 32-77 years) received tamoxifen alone as first-line treatment for recurrence. 20 patients (28%) showed a response to this therapy and 52 (72%) did not. Of 32 ER-positive tumours, 12 (37·5%) showed an objective response to tamoxifen compared with only 2 of 40 (5%) ER-negative tumours (p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(89)91202-6