The Comparative Activity of Some Enzymes in Sheep, Cattle and Rats—Normal Serum and Tissue Levels and Changes During Experimental Liver Necrosis
A survey has been carried out of the distribution of some enzymes in the tissues, whole blood and serum of normal sheep, cattle and rats. The enzymes studied were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), glutamate dehydrogenase (GD), L-lactate dehydrogenase (...
Gespeichert in:
| Veröffentlicht in: | Research in veterinary science 1962-07, Vol.3 (3), p.256-270 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 270 |
|---|---|
| container_issue | 3 |
| container_start_page | 256 |
| container_title | Research in veterinary science |
| container_volume | 3 |
| creator | Boyd, J.W. |
| description | A survey has been carried out of the distribution of some enzymes in the tissues, whole blood and serum of normal sheep, cattle and rats. The enzymes studied were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), glutamate dehydrogenase (GD), L-lactate dehydrogenase (LD) and TPN-dependent isocitrate dehydrogenase (ICD).
Carbon tetrachloride was given orally to 4 sheep, 2 calves, 1 cow and 26 rats. Centrilobular liver necrosis was observed histologically in liver samples obtained post-mortem from the rats, and by biopsy from the cow, 3 of the sheep and both calves.
The activities of the enzymes were assayed in serum collected at intervals from these animals. These activities, except of GPT in the cow, sheep and calves, increased during the period of necrosis of liver cells up to 48 hours. There was a tendency for enzymes most active in liver to increase most. There also appeared to be some relationship between the amount of the increase and the extent of hepatic necrosis.
The pattern of serum enzyme elevations was similar in the cow, sheep and calves and differed from that in rats.
The serum enzyme most affected by liver damage was GPT in the rat and GD in sheep and calves. |
| doi_str_mv | 10.1016/S0034-5288(18)34899-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2155868028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0034528818348999</els_id><sourcerecordid>2155868028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1828-2d7b27963c8d2dd6ef315915e508ff9df778b25ba0efa9977ca9cbb10d5071013</originalsourceid><addsrcrecordid>eNqFkN9KIzEYxcOisNX1ERYC3rjguEmmmUmuRMb6B4qC7V6HTPKNjXT-bDJTrFc-g_iE-ySmrXi7Vwc-zjnf4YfQT0rOKKHZ7xkh6TjhTIgTKn6lYyFlIr-hEeUpS1iW0T00-rJ8RwchPBFCxpTmI_Q2XwAu2rrTXvduBfjCRHH9GrcVnrU14Enzsq4hYNfg2QKgO8WF7vslYN1Y_KD78O_1_a71tV7iGfih3t7nLoQB8BRWsAzbS7HQzWOsuRy8ax7x5LkD72po-pibxsce34HxbXDhB9qv9DLA0aceoj9Xk3lxk0zvr2-Li2liqGAiYTYvWS6z1AjLrM2gSimXlAMnoqqkrfJclIyXmkClpcxzo6UpS0osJ3nklh6i411v59u_A4RePbWDb-JLxSjnIhOEiejiO9dmXPBQqS7u1n6tKFEb_GqLX23YKirUFr-SMXe-y0UAsHLgVTAOGgPWeTC9sq37T8MHxIOOrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2155868028</pqid></control><display><type>article</type><title>The Comparative Activity of Some Enzymes in Sheep, Cattle and Rats—Normal Serum and Tissue Levels and Changes During Experimental Liver Necrosis</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Boyd, J.W.</creator><creatorcontrib>Boyd, J.W.</creatorcontrib><description>A survey has been carried out of the distribution of some enzymes in the tissues, whole blood and serum of normal sheep, cattle and rats. The enzymes studied were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), glutamate dehydrogenase (GD), L-lactate dehydrogenase (LD) and TPN-dependent isocitrate dehydrogenase (ICD).
Carbon tetrachloride was given orally to 4 sheep, 2 calves, 1 cow and 26 rats. Centrilobular liver necrosis was observed histologically in liver samples obtained post-mortem from the rats, and by biopsy from the cow, 3 of the sheep and both calves.
The activities of the enzymes were assayed in serum collected at intervals from these animals. These activities, except of GPT in the cow, sheep and calves, increased during the period of necrosis of liver cells up to 48 hours. There was a tendency for enzymes most active in liver to increase most. There also appeared to be some relationship between the amount of the increase and the extent of hepatic necrosis.
The pattern of serum enzyme elevations was similar in the cow, sheep and calves and differed from that in rats.
The serum enzyme most affected by liver damage was GPT in the rat and GD in sheep and calves.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(18)34899-9</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biopsy ; Calves ; Carbon tetrachloride ; Cattle ; Dehydrogenase ; Dehydrogenases ; Enzymes ; Gangrene ; Glutamate dehydrogenase ; Hepatocytes ; Isocitrate dehydrogenase ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Liver ; Necrosis ; Pyruvic acid ; Rats ; Sheep ; Tissues ; Transaminase ; Veterinary medicine</subject><ispartof>Research in veterinary science, 1962-07, Vol.3 (3), p.256-270</ispartof><rights>1962</rights><rights>Copyright Elsevier Limited Jul 1962</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1828-2d7b27963c8d2dd6ef315915e508ff9df778b25ba0efa9977ca9cbb10d5071013</citedby><cites>FETCH-LOGICAL-c1828-2d7b27963c8d2dd6ef315915e508ff9df778b25ba0efa9977ca9cbb10d5071013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0034-5288(18)34899-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids></links><search><creatorcontrib>Boyd, J.W.</creatorcontrib><title>The Comparative Activity of Some Enzymes in Sheep, Cattle and Rats—Normal Serum and Tissue Levels and Changes During Experimental Liver Necrosis</title><title>Research in veterinary science</title><description>A survey has been carried out of the distribution of some enzymes in the tissues, whole blood and serum of normal sheep, cattle and rats. The enzymes studied were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), glutamate dehydrogenase (GD), L-lactate dehydrogenase (LD) and TPN-dependent isocitrate dehydrogenase (ICD).
Carbon tetrachloride was given orally to 4 sheep, 2 calves, 1 cow and 26 rats. Centrilobular liver necrosis was observed histologically in liver samples obtained post-mortem from the rats, and by biopsy from the cow, 3 of the sheep and both calves.
The activities of the enzymes were assayed in serum collected at intervals from these animals. These activities, except of GPT in the cow, sheep and calves, increased during the period of necrosis of liver cells up to 48 hours. There was a tendency for enzymes most active in liver to increase most. There also appeared to be some relationship between the amount of the increase and the extent of hepatic necrosis.
The pattern of serum enzyme elevations was similar in the cow, sheep and calves and differed from that in rats.
The serum enzyme most affected by liver damage was GPT in the rat and GD in sheep and calves.</description><subject>Biopsy</subject><subject>Calves</subject><subject>Carbon tetrachloride</subject><subject>Cattle</subject><subject>Dehydrogenase</subject><subject>Dehydrogenases</subject><subject>Enzymes</subject><subject>Gangrene</subject><subject>Glutamate dehydrogenase</subject><subject>Hepatocytes</subject><subject>Isocitrate dehydrogenase</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Liver</subject><subject>Necrosis</subject><subject>Pyruvic acid</subject><subject>Rats</subject><subject>Sheep</subject><subject>Tissues</subject><subject>Transaminase</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><recordid>eNqFkN9KIzEYxcOisNX1ERYC3rjguEmmmUmuRMb6B4qC7V6HTPKNjXT-bDJTrFc-g_iE-ySmrXi7Vwc-zjnf4YfQT0rOKKHZ7xkh6TjhTIgTKn6lYyFlIr-hEeUpS1iW0T00-rJ8RwchPBFCxpTmI_Q2XwAu2rrTXvduBfjCRHH9GrcVnrU14Enzsq4hYNfg2QKgO8WF7vslYN1Y_KD78O_1_a71tV7iGfih3t7nLoQB8BRWsAzbS7HQzWOsuRy8ax7x5LkD72po-pibxsce34HxbXDhB9qv9DLA0aceoj9Xk3lxk0zvr2-Li2liqGAiYTYvWS6z1AjLrM2gSimXlAMnoqqkrfJclIyXmkClpcxzo6UpS0osJ3nklh6i411v59u_A4RePbWDb-JLxSjnIhOEiejiO9dmXPBQqS7u1n6tKFEb_GqLX23YKirUFr-SMXe-y0UAsHLgVTAOGgPWeTC9sq37T8MHxIOOrQ</recordid><startdate>196207</startdate><enddate>196207</enddate><creator>Boyd, J.W.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>196207</creationdate><title>The Comparative Activity of Some Enzymes in Sheep, Cattle and Rats—Normal Serum and Tissue Levels and Changes During Experimental Liver Necrosis</title><author>Boyd, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1828-2d7b27963c8d2dd6ef315915e508ff9df778b25ba0efa9977ca9cbb10d5071013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Biopsy</topic><topic>Calves</topic><topic>Carbon tetrachloride</topic><topic>Cattle</topic><topic>Dehydrogenase</topic><topic>Dehydrogenases</topic><topic>Enzymes</topic><topic>Gangrene</topic><topic>Glutamate dehydrogenase</topic><topic>Hepatocytes</topic><topic>Isocitrate dehydrogenase</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Liver</topic><topic>Necrosis</topic><topic>Pyruvic acid</topic><topic>Rats</topic><topic>Sheep</topic><topic>Tissues</topic><topic>Transaminase</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyd, J.W.</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyd, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Comparative Activity of Some Enzymes in Sheep, Cattle and Rats—Normal Serum and Tissue Levels and Changes During Experimental Liver Necrosis</atitle><jtitle>Research in veterinary science</jtitle><date>1962-07</date><risdate>1962</risdate><volume>3</volume><issue>3</issue><spage>256</spage><epage>270</epage><pages>256-270</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>A survey has been carried out of the distribution of some enzymes in the tissues, whole blood and serum of normal sheep, cattle and rats. The enzymes studied were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), glutamate dehydrogenase (GD), L-lactate dehydrogenase (LD) and TPN-dependent isocitrate dehydrogenase (ICD).
Carbon tetrachloride was given orally to 4 sheep, 2 calves, 1 cow and 26 rats. Centrilobular liver necrosis was observed histologically in liver samples obtained post-mortem from the rats, and by biopsy from the cow, 3 of the sheep and both calves.
The activities of the enzymes were assayed in serum collected at intervals from these animals. These activities, except of GPT in the cow, sheep and calves, increased during the period of necrosis of liver cells up to 48 hours. There was a tendency for enzymes most active in liver to increase most. There also appeared to be some relationship between the amount of the increase and the extent of hepatic necrosis.
The pattern of serum enzyme elevations was similar in the cow, sheep and calves and differed from that in rats.
The serum enzyme most affected by liver damage was GPT in the rat and GD in sheep and calves.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0034-5288(18)34899-9</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 1962-07, Vol.3 (3), p.256-270 |
| issn | 0034-5288 1532-2661 |
| language | eng |
| recordid | cdi_proquest_journals_2155868028 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Biopsy Calves Carbon tetrachloride Cattle Dehydrogenase Dehydrogenases Enzymes Gangrene Glutamate dehydrogenase Hepatocytes Isocitrate dehydrogenase L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Liver Necrosis Pyruvic acid Rats Sheep Tissues Transaminase Veterinary medicine |
| title | The Comparative Activity of Some Enzymes in Sheep, Cattle and Rats—Normal Serum and Tissue Levels and Changes During Experimental Liver Necrosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T22%3A56%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Comparative%20Activity%20of%20Some%20Enzymes%20in%20Sheep,%20Cattle%20and%20Rats%E2%80%94Normal%20Serum%20and%20Tissue%20Levels%20and%20Changes%20During%20Experimental%20Liver%20Necrosis&rft.jtitle=Research%20in%20veterinary%20science&rft.au=Boyd,%20J.W.&rft.date=1962-07&rft.volume=3&rft.issue=3&rft.spage=256&rft.epage=270&rft.pages=256-270&rft.issn=0034-5288&rft.eissn=1532-2661&rft_id=info:doi/10.1016/S0034-5288(18)34899-9&rft_dat=%3Cproquest_cross%3E2155868028%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2155868028&rft_id=info:pmid/&rft_els_id=S0034528818348999&rfr_iscdi=true |