Synthesis of Enantiopure Isosteres of Amino Acids Containing a Quaternary Stereocenter: Experimental and Computational Evaluation of a Novel Class of Atropisomers

Electrophilic amination of diastereomeric 4‐methoxycarbonyl pyrrolidin‐2‐ones allowed to prepare both diastereomers of an amino acid bearing a quaternary chiral center, a key intermediate to antibiotic 8‐methoxyquinolone carboxylic acid. Within this synthesis, novel atropisomers, exceedingly stable...

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Veröffentlicht in:	European journal of organic chemistry 2018-12, Vol.2018 (46), p.6524-6536
Hauptverfasser:	Amabili, Paolo, Amici, Adolfo, Campisi, Giovanni, Guerra, Giulia, Monari, Magda, Orena, Mario, Piccinelli, Fabio, Rinaldi, Samuele, Tolomelli, Alessandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibiotics Atropisomers Computational chemistry Kinetics Quaternary stereocenter Synthesis
Online-Zugang:	Volltext
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