Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death

Aims Drug-induced QTc-prolongation, resulting from inhibition of HERG potassium channels may lead to serious ventricular arrhythmias and sudden death. We studied the quantitative anti-HERG activity of pro-arrhythmic drugs as a risk factor for this outcome in day-to-day practice. Methods and results...

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Veröffentlicht in:	European heart journal 2005-03, Vol.26 (6), p.590-597
Hauptverfasser:	De Bruin, M.L., Pettersson, M., Meyboom, R.H.B., Hoes, A.W., Leufkens, H.G.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse Drug Reaction Reporting Systems Aged Anti-Arrhythmia Agents - therapeutic use Arrhythmia Arrhythmias, Cardiac - chemically induced Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Databases, Factual Death, Sudden - etiology ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels Female Gender Identity Heart Heart Ventricles Humans Long QT Syndrome - chemically induced Male Medical sciences Middle Aged Odds Ratio Potassium Channel Blockers - adverse effects Potassium Channel Blockers - blood Potassium Channel Blockers - therapeutic use Potassium channels Potassium Channels, Voltage-Gated - antagonists & inhibitors Pre-clinical drug evaluation Risk Sudden death Torsades de pointes World Health Organization
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