Salmonella persisters undermine host immune defenses during antibiotic treatment

Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of species by macrophages, nongrowing persisters also occur, but their physiological state is poorly understoo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-12, Vol.362 (6419), p.1156-1160
Hauptverfasser:	Stapels, Daphne A C, Hill, Peter W S, Westermann, Alexander J, Fisher, Robert A, Thurston, Teresa L, Saliba, Antoine-Emmanuel, Blommestein, Isabelle, Vogel, Jörg, Helaine, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial diseases Cells, Cultured Drug Resistance, Bacterial Effectors Environmental stress Female Genomic Islands Host-Pathogen Interactions - immunology Immune response Immunity, Innate Inflammation Innate immunity Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Mice Mice, Inbred C57BL Pathogenicity Pathogens Recurrence Salmonella Salmonella Infections - drug therapy Salmonella Infections - immunology Salmonella Infections - microbiology Salmonella typhimurium - drug effects Salmonella typhimurium - metabolism Type III Secretion Systems - metabolism Virulence Virulence factors
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