Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children’s Health
•We studied the association between prenatal exposure to low levels of OCP and infant neurodevelopment through a prospective birth cohort study.•Infants prenatally exposed to cis-HCE showed a decreased Mental Developmental Index at 18 months.•Prenatal exposure to OCPs affects infant neurodevelopment...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2018-12, Vol.69, p.201-208 |
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| creator | Yamazaki, Keiko Araki, Atsuko Nakajima, Sonomi Miyashita, Chihiro Ikeno, Tamiko Itoh, Sachiko Minatoya, Machiko Kobayashi, Sumitaka Mizutani, Futoshi Chisaki, Yoichi Kishi, Reiko |
| description | •We studied the association between prenatal exposure to low levels of OCP and infant neurodevelopment through a prospective birth cohort study.•Infants prenatally exposed to cis-HCE showed a decreased Mental Developmental Index at 18 months.•Prenatal exposure to OCPs affects infant neurodevelopment.
Organochlorine pesticides (OCPs) are environmental contaminants that persist in the environment and bioaccumulate through the food chain in humans and animals. Although previous studies have shown an association between prenatal OCP exposure and subsequent neurodevelopment, the levels of OCPs included in these studies were inconsistent. A hospital-based prospective birth cohort study was conducted to examine the associations between prenatal exposure to relatively low levels of OCPs and neurodevelopment in infants at 6 (n=164) and 18 (n=115)months of age. Blood samples were analyzed using gas chromatography/mass spectrometry techniques to quantify 29 OCPs. The Bayley Scales of Infant Development 2nd edition (BSID-II) was used to assess the Mental and Psychomotor Developmental Index. After controlling for confounders, we found an inverse association between prenatal exposure to cis-heptachlor epoxide and the Mental Developmental Index at 18 months of age. Furthermore, infants born to mothers with prenatal concentrations of cis-heptachlor epoxide in the highest quartile had Mental Developmental Index scores −9.8 (95% confidence interval: −16.4, −3.1) lower than that recorded for infants born to mothers with concentrations of cis-heptachlor epoxide in the first quartile (p for trend |
| doi_str_mv | 10.1016/j.neuro.2017.11.011 |
| format | Article |
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Organochlorine pesticides (OCPs) are environmental contaminants that persist in the environment and bioaccumulate through the food chain in humans and animals. Although previous studies have shown an association between prenatal OCP exposure and subsequent neurodevelopment, the levels of OCPs included in these studies were inconsistent. A hospital-based prospective birth cohort study was conducted to examine the associations between prenatal exposure to relatively low levels of OCPs and neurodevelopment in infants at 6 (n=164) and 18 (n=115)months of age. Blood samples were analyzed using gas chromatography/mass spectrometry techniques to quantify 29 OCPs. The Bayley Scales of Infant Development 2nd edition (BSID-II) was used to assess the Mental and Psychomotor Developmental Index. After controlling for confounders, we found an inverse association between prenatal exposure to cis-heptachlor epoxide and the Mental Developmental Index at 18 months of age. Furthermore, infants born to mothers with prenatal concentrations of cis-heptachlor epoxide in the highest quartile had Mental Developmental Index scores −9.8 (95% confidence interval: −16.4, −3.1) lower than that recorded for infants born to mothers with concentrations of cis-heptachlor epoxide in the first quartile (p for trend <0.01). These results support the hypothesis that prenatal exposure to OCPs, especially cis-heptachlor epoxide, may have an adverse effect on the neurodevelopment of infants at specific ages, even at low levels.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2017.11.011</identifier><identifier>PMID: 29203293</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Bayley Scales of Infant Development(BSID-II) ; Bioaccumulation ; Birth cohort ; Child Development - drug effects ; Child Development - physiology ; Child Health - trends ; Children ; Childrens health ; Cohort Studies ; Confidence intervals ; Contaminants ; Environmental Pollutants - adverse effects ; Exposure ; Female ; Food chains ; Gas chromatography ; Heptachlor ; Heptachlor epoxide ; Human exposure ; Humans ; Hydrocarbons, Chlorinated - adverse effects ; Infant ; Infants ; Japan - epidemiology ; Male ; Mass spectrometry ; Mass spectroscopy ; Maternal & child health ; Maternal Exposure - adverse effects ; Mental health ; Neurodevelopment ; Organic compounds ; Organochlorine pesticide ; Organochlorine pesticides ; Pesticides ; Pesticides - adverse effects ; Pregnancy ; Pregnancy complications ; Prenatal experience ; Prenatal exposure ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - diagnosis ; Prenatal Exposure Delayed Effects - epidemiology ; Prospective Studies ; Surveys and Questionnaires</subject><ispartof>Neurotoxicology (Park Forest South), 2018-12, Vol.69, p.201-208</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Dec 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-97b29b9869f73189776195d1b5cae827879579fb2c49d0abe122faa35f3ab8163</citedby><cites>FETCH-LOGICAL-c542t-97b29b9869f73189776195d1b5cae827879579fb2c49d0abe122faa35f3ab8163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuro.2017.11.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29203293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamazaki, Keiko</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Nakajima, Sonomi</creatorcontrib><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Ikeno, Tamiko</creatorcontrib><creatorcontrib>Itoh, Sachiko</creatorcontrib><creatorcontrib>Minatoya, Machiko</creatorcontrib><creatorcontrib>Kobayashi, Sumitaka</creatorcontrib><creatorcontrib>Mizutani, Futoshi</creatorcontrib><creatorcontrib>Chisaki, Yoichi</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><title>Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children’s Health</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>•We studied the association between prenatal exposure to low levels of OCP and infant neurodevelopment through a prospective birth cohort study.•Infants prenatally exposed to cis-HCE showed a decreased Mental Developmental Index at 18 months.•Prenatal exposure to OCPs affects infant neurodevelopment.
Organochlorine pesticides (OCPs) are environmental contaminants that persist in the environment and bioaccumulate through the food chain in humans and animals. Although previous studies have shown an association between prenatal OCP exposure and subsequent neurodevelopment, the levels of OCPs included in these studies were inconsistent. A hospital-based prospective birth cohort study was conducted to examine the associations between prenatal exposure to relatively low levels of OCPs and neurodevelopment in infants at 6 (n=164) and 18 (n=115)months of age. Blood samples were analyzed using gas chromatography/mass spectrometry techniques to quantify 29 OCPs. The Bayley Scales of Infant Development 2nd edition (BSID-II) was used to assess the Mental and Psychomotor Developmental Index. After controlling for confounders, we found an inverse association between prenatal exposure to cis-heptachlor epoxide and the Mental Developmental Index at 18 months of age. Furthermore, infants born to mothers with prenatal concentrations of cis-heptachlor epoxide in the highest quartile had Mental Developmental Index scores −9.8 (95% confidence interval: −16.4, −3.1) lower than that recorded for infants born to mothers with concentrations of cis-heptachlor epoxide in the first quartile (p for trend <0.01). These results support the hypothesis that prenatal exposure to OCPs, especially cis-heptachlor epoxide, may have an adverse effect on the neurodevelopment of infants at specific ages, even at low levels.</description><subject>Adult</subject><subject>Bayley Scales of Infant Development(BSID-II)</subject><subject>Bioaccumulation</subject><subject>Birth cohort</subject><subject>Child Development - drug effects</subject><subject>Child Development - physiology</subject><subject>Child Health - trends</subject><subject>Children</subject><subject>Childrens health</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Contaminants</subject><subject>Environmental Pollutants - adverse effects</subject><subject>Exposure</subject><subject>Female</subject><subject>Food chains</subject><subject>Gas chromatography</subject><subject>Heptachlor</subject><subject>Heptachlor epoxide</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - adverse effects</subject><subject>Infant</subject><subject>Infants</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Maternal & child health</subject><subject>Maternal Exposure - adverse effects</subject><subject>Mental health</subject><subject>Neurodevelopment</subject><subject>Organic compounds</subject><subject>Organochlorine pesticide</subject><subject>Organochlorine pesticides</subject><subject>Pesticides</subject><subject>Pesticides - adverse effects</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - diagnosis</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prospective Studies</subject><subject>Surveys and Questionnaires</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEokvhCZCQJc4bMk4Tx0gcqlVhkSpxoEjcLMeeNN4mdrCdLXvjNXgm3oInwdktHDmNrPm_f8bzZ9lLKHIooH6zyy3O3uW0AJYD5AXAo2wFDaNrzgAeZ6ukgnUD5dez7FkIu6KAitX8aXZGOS1KystV9usyBKeMjMZZ0mK8R7Rk8mhllAPB75MLs0cSHXH-Vlqn-sF5Y5FMGKJRRmMg0moSeyQj2gVanlM4qN6NLjpPNO5xcNPSJa4jxnbSxkRFIm8TXR8BaMjobOzDW3KTrLbu7k4a7cjnOOsDSbtd2b3xzh5dFmDTm0GnPX__-BnIFuUQ--fZk04OAV881PPsy_urm812ff3pw8fN5fVaVRc0puO0lLe8qXnHSmg4YzXwSkNbKYkNZQ3jFeNdS9UF14VsESjtpCyrrpRtA3V5nr0--U7efZvTHcTOzd6mkYJCVdYlZVWRVOVJpbwLwWMnJm9G6Q8CCrEEKHbiGKBYAhQAIgWYqFcP3nM7ov7H_E0sCd6dBJh-uDfoRVAGrUJtPKootDP_HfAHL3ayUQ</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Yamazaki, Keiko</creator><creator>Araki, Atsuko</creator><creator>Nakajima, Sonomi</creator><creator>Miyashita, Chihiro</creator><creator>Ikeno, Tamiko</creator><creator>Itoh, Sachiko</creator><creator>Minatoya, Machiko</creator><creator>Kobayashi, Sumitaka</creator><creator>Mizutani, Futoshi</creator><creator>Chisaki, Yoichi</creator><creator>Kishi, Reiko</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201812</creationdate><title>Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children’s Health</title><author>Yamazaki, Keiko ; Araki, Atsuko ; Nakajima, Sonomi ; Miyashita, Chihiro ; Ikeno, Tamiko ; Itoh, Sachiko ; Minatoya, Machiko ; Kobayashi, Sumitaka ; Mizutani, Futoshi ; Chisaki, Yoichi ; Kishi, Reiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-97b29b9869f73189776195d1b5cae827879579fb2c49d0abe122faa35f3ab8163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Bayley Scales of Infant Development(BSID-II)</topic><topic>Bioaccumulation</topic><topic>Birth cohort</topic><topic>Child Development - drug effects</topic><topic>Child Development - physiology</topic><topic>Child Health - trends</topic><topic>Children</topic><topic>Childrens health</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Contaminants</topic><topic>Environmental Pollutants - adverse effects</topic><topic>Exposure</topic><topic>Female</topic><topic>Food chains</topic><topic>Gas chromatography</topic><topic>Heptachlor</topic><topic>Heptachlor epoxide</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Hydrocarbons, Chlorinated - adverse effects</topic><topic>Infant</topic><topic>Infants</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Maternal & child health</topic><topic>Maternal Exposure - adverse effects</topic><topic>Mental health</topic><topic>Neurodevelopment</topic><topic>Organic compounds</topic><topic>Organochlorine pesticide</topic><topic>Organochlorine pesticides</topic><topic>Pesticides</topic><topic>Pesticides - adverse effects</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Prenatal experience</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - diagnosis</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prospective Studies</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, Keiko</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Nakajima, Sonomi</creatorcontrib><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Ikeno, Tamiko</creatorcontrib><creatorcontrib>Itoh, Sachiko</creatorcontrib><creatorcontrib>Minatoya, Machiko</creatorcontrib><creatorcontrib>Kobayashi, Sumitaka</creatorcontrib><creatorcontrib>Mizutani, Futoshi</creatorcontrib><creatorcontrib>Chisaki, Yoichi</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, Keiko</au><au>Araki, Atsuko</au><au>Nakajima, Sonomi</au><au>Miyashita, Chihiro</au><au>Ikeno, Tamiko</au><au>Itoh, Sachiko</au><au>Minatoya, Machiko</au><au>Kobayashi, Sumitaka</au><au>Mizutani, Futoshi</au><au>Chisaki, Yoichi</au><au>Kishi, Reiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children’s Health</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2018-12</date><risdate>2018</risdate><volume>69</volume><spage>201</spage><epage>208</epage><pages>201-208</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>•We studied the association between prenatal exposure to low levels of OCP and infant neurodevelopment through a prospective birth cohort study.•Infants prenatally exposed to cis-HCE showed a decreased Mental Developmental Index at 18 months.•Prenatal exposure to OCPs affects infant neurodevelopment.
Organochlorine pesticides (OCPs) are environmental contaminants that persist in the environment and bioaccumulate through the food chain in humans and animals. Although previous studies have shown an association between prenatal OCP exposure and subsequent neurodevelopment, the levels of OCPs included in these studies were inconsistent. A hospital-based prospective birth cohort study was conducted to examine the associations between prenatal exposure to relatively low levels of OCPs and neurodevelopment in infants at 6 (n=164) and 18 (n=115)months of age. Blood samples were analyzed using gas chromatography/mass spectrometry techniques to quantify 29 OCPs. The Bayley Scales of Infant Development 2nd edition (BSID-II) was used to assess the Mental and Psychomotor Developmental Index. After controlling for confounders, we found an inverse association between prenatal exposure to cis-heptachlor epoxide and the Mental Developmental Index at 18 months of age. Furthermore, infants born to mothers with prenatal concentrations of cis-heptachlor epoxide in the highest quartile had Mental Developmental Index scores −9.8 (95% confidence interval: −16.4, −3.1) lower than that recorded for infants born to mothers with concentrations of cis-heptachlor epoxide in the first quartile (p for trend <0.01). These results support the hypothesis that prenatal exposure to OCPs, especially cis-heptachlor epoxide, may have an adverse effect on the neurodevelopment of infants at specific ages, even at low levels.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29203293</pmid><doi>10.1016/j.neuro.2017.11.011</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurotoxicology (Park Forest South), 2018-12, Vol.69, p.201-208 |
| issn | 0161-813X 1872-9711 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Bayley Scales of Infant Development(BSID-II) Bioaccumulation Birth cohort Child Development - drug effects Child Development - physiology Child Health - trends Children Childrens health Cohort Studies Confidence intervals Contaminants Environmental Pollutants - adverse effects Exposure Female Food chains Gas chromatography Heptachlor Heptachlor epoxide Human exposure Humans Hydrocarbons, Chlorinated - adverse effects Infant Infants Japan - epidemiology Male Mass spectrometry Mass spectroscopy Maternal & child health Maternal Exposure - adverse effects Mental health Neurodevelopment Organic compounds Organochlorine pesticide Organochlorine pesticides Pesticides Pesticides - adverse effects Pregnancy Pregnancy complications Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - diagnosis Prenatal Exposure Delayed Effects - epidemiology Prospective Studies Surveys and Questionnaires |
| title | Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children’s Health |
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