Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal

•Chronic ketamine disrupts midbrain field potentials and elicits a sensory rebound.•Clozapine blocks the auditory rebound induced by a higher dose of ketamine.•NMDA receptors stimulation in the prelimbic cortex mimics clozapine effects.•NMDA effects on auditory potentials can be under control of 5-H...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2018-12, Vol.69, p.1-10
Hauptverfasser:	Incrocci, Roberta Monteiro, Paliarin, Franciely, Nobre, Manoel Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonist drugs Antagonists Antipsychotics Auditory evoked potentials Auditory perception Behavior Channel gating Clozapine Clozapine - pharmacology Clozapine - therapeutic use Efflux Electrophysiology Event-related potentials Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Excitatory Amino Acid Antagonists - toxicity GABA Glutamate Glutamic acid receptors (ionotropic) Hallucinations Inferior colliculus Information processing Ketamine Ketamine - toxicity Latency Localization Male Mental disorders Mesencephalon Microinjections - methods N-Methyl-D-aspartic acid receptors Neurotoxicity Neurotransmission Neurotransmitters Outbreaks Pharmacology Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Wistar Receptors Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - metabolism Sensorimotor gating Sensory stimulation Serotonin Serotonin Antagonists - pharmacology Serotonin Antagonists - therapeutic use Somatosensory cortex Sound localization Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - metabolism Withdrawal
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