Fetus as an Allograft: A Review
Allograft is a tissue or organ obtained from one member of a species and grafted to a genetically dissimilar member of the same species. Pregnant mother nourishing within itself a fetus acts as an antigenically foreign body. The foreign nature of conceptus, caused by inheritance of genes from its fa...
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| Veröffentlicht in: | Theriogenology insight 2018-08, Vol.8 (2), p.87-89 |
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| creator | Wani, Jaan Mohammad |
| description | Allograft is a tissue or organ obtained from one member of a species and grafted to a genetically dissimilar member of the same species. Pregnant mother nourishing within itself a fetus acts as an antigenically foreign body. The foreign nature of conceptus, caused by inheritance of genes from its father that encode for proteins foreign to its mother, poses a unique problem for species that are viviparous in which mothers immune system can potentially destroy the conceptus. It requires modulation of the maternal immune system which limits fetal allograft rejection without compromising the ability of the mother to fend off infection. While as tissue (other than fetus) grafted inside uterus is instantaneously rejected by mother/dam. Host T cells responds to peptide epitopes of MHC molecules of grafted cells. |
| doi_str_mv | 10.30954/2277-3371.02.2018.7 |
| format | Article |
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| ispartof | Theriogenology insight, 2018-08, Vol.8 (2), p.87-89 |
| issn | 2249-6610 2277-3371 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Abortion Antigens Apoptosis Cell cycle Cell growth Cytokines Cytotoxicity Dendritic cells Epitopes Fetuses Graft rejection Growth factors Immune system Immunoglobulins Immunology Lymphocytes Lymphocytes T Major histocompatibility complex Medical research Pregnancy Proteins Species Uterus |
| title | Fetus as an Allograft: A Review |
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