CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM 2, neurodegeneration and cognitive decline

Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether PGRN expression is changed in a disease severity‐specific manner in AD. We measured PGRN in cerebrospinal fluid (...

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Veröffentlicht in:	EMBO molecular medicine 2018-12, Vol.10 (12)
Hauptverfasser:	Suárez‐Calvet, Marc, Capell, Anja, Araque Caballero, Miguel Ángel, Morenas‐Rodríguez, Estrella, Fellerer, Katrin, Franzmeier, Nicolai, Kleinberger, Gernot, Eren, Erden, Deming, Yuetiva, Piccio, Laura, Karch, Celeste M, Cruchaga, Carlos, Paumier, Katrina, Bateman, Randall J, Fagan, Anne M, Morris, John C, Levin, Johannes, Danek, Adrian, Jucker, Mathias, Masters, Colin L, Rossor, Martin N, Ringman, John M, Shaw, Leslie M, Trojanowski, John Q, Weiner, Michael, Ewers, Michael, Haass, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Cerebrospinal fluid Clinical trials Cognitive ability Inflammation Medical imaging Microglia Mutation Myeloid cells Neurodegeneration Neurodegenerative diseases Neuroimaging
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