18F-FDG PET-CT respiratory gating in characterization of pulmonary lesions: approximation towards clinical indications
Aim To evaluate the effect of the 18F-FDG PET-CT respiratory gating (4D) study in the correct documentation of pulmonary lesions with faint uptake in standard PET-CT. Methods Forty-two pulmonary lesions with a low or no detectable uptake of FDG (SUV max
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| Veröffentlicht in: | Annals of nuclear medicine 2010-04, Vol.24 (3), p.207-214 |
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| creator | García Vicente, A. M. Soriano Castrejón, A. M. Talavera Rubio, M. P. León Martín, A. A. Palomar Muñoz, A. M. Pilkington Woll, J. P. Poblete García, V. M. |
| description | Aim
To evaluate the effect of the 18F-FDG PET-CT respiratory gating (4D) study in the correct documentation of pulmonary lesions with faint uptake in standard PET-CT.
Methods
Forty-two pulmonary lesions with a low or no detectable uptake of FDG (SUV
max
|
| doi_str_mv | 10.1007/s12149-010-0345-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_215046569</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2010825381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2502-115c92f35f3a7afed70e966be42608b47b34a7a82247a4f4aaa600a85cf9c95c3</originalsourceid><addsrcrecordid>eNp1kEFPAyEQhYnRxFr9Ad6IdxRYYFlvprbVxEQP9UymFOo222WFrVp_vTRr4snTJDPfezPzELpk9JpRWt4kxpmoCGWU0EJIwo_QiGkliBJFcYxGtGKClEyXp-gspQ2lXEvNR-iD6RmZ3c_xy3RBJgscXerqCH2Ie7yGvm7XuG6xfYMItnex_s690OLgcbdrtqGFzDUu5V66xdB1MXzV24HpwyfEVcK2qdvaQpONVrkeZukcnXhokrv4rWP0OpsuJg_k6Xn-OLl7IpZLyglj0lbcF9IXUIJ3q5K6SqmlE1xRvRTlshB5oDkXJQgvAEBRClpaX9lK2mKMrgbffNj7zqXebMIutnml4UxSoaSqMsQGyMaQUnTedDE_EfeGUXNI1wzpmpyuOaRreNbwQZMy265d_DP-X_QDyPd-Cg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215046569</pqid></control><display><type>article</type><title>18F-FDG PET-CT respiratory gating in characterization of pulmonary lesions: approximation towards clinical indications</title><source>Springer Nature - Complete Springer Journals</source><creator>García Vicente, A. M. ; Soriano Castrejón, A. M. ; Talavera Rubio, M. P. ; León Martín, A. A. ; Palomar Muñoz, A. M. ; Pilkington Woll, J. P. ; Poblete García, V. M.</creator><creatorcontrib>García Vicente, A. M. ; Soriano Castrejón, A. M. ; Talavera Rubio, M. P. ; León Martín, A. A. ; Palomar Muñoz, A. M. ; Pilkington Woll, J. P. ; Poblete García, V. M.</creatorcontrib><description>Aim
To evaluate the effect of the 18F-FDG PET-CT respiratory gating (4D) study in the correct documentation of pulmonary lesions with faint uptake in standard PET-CT.
Methods
Forty-two pulmonary lesions with a low or no detectable uptake of FDG (SUV
max
< 2.5) in 3D PET-CT were prospectively evaluated in 28 patients (19 males and 9 females), mean age 66.5 years (41–81). 22 patients had neoplastic background. A conventional PET-CT (3D) total body scan was performed approximately 60 min after iv injection of a mean dose of 370 MBq. Furthermore, a 4D PET-CT (synchronized with respiratory movement) thorax study was acquired. SUV
max
was determined for each lesion in both studies. For the 4D studies, we selected the SUV
max
in respiratory period with the highest uptake (“best bin”). We calculated the SUV
max
percentage difference between 3D and 4D PET-CT (% difference = SUV
max
4D − SUV
max
3D/SUV
max
3D × 100) and the relation of this value with the size and locations of the lesions. In 4D study, any lesion with SUV
max
≥ 2.5 was classified as malignant. We assessed the changes of lesion classification (from benign to malignant) applying the 4D technique. The final diagnosis was obtained by histological assessment or clinical and radiological follow-up longer than 12 months.
Results
Forty out of 42 lesions showed an increase of SUV
max
in the 4D study with respect to 3D. The mean SUV
max
in the 3D and 4D PET-CT studies were 1.33 (±0.59) and 2.26 (±0.87), respectively. The SUV
max
percentage difference mean between both techniques was 83.3% (±80.81).The smaller the lesion the greater was the SUV
max
percentage difference (
P
< 0.05). No differences were observed depending on the location of the lesion. In 40% of cases, there was a change in the final classification of lesions from benign to malignant. In the final diagnosis, 24 lesions were malignant. 4D PET-CT diagnosed correctly the 52% of them.
Conclusions
The 4D PET-CT study permitted a better characterization of malignant lung lesions compared with the standard PET-CT, because of its higher sensitivity. 4D PET-CT is a recommendable technique in the early diagnosis of malignant lesions.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-010-0345-2</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Imaging ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Original Article ; Radiology</subject><ispartof>Annals of nuclear medicine, 2010-04, Vol.24 (3), p.207-214</ispartof><rights>The Japanese Society of Nuclear Medicine 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2502-115c92f35f3a7afed70e966be42608b47b34a7a82247a4f4aaa600a85cf9c95c3</citedby><cites>FETCH-LOGICAL-c2502-115c92f35f3a7afed70e966be42608b47b34a7a82247a4f4aaa600a85cf9c95c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-010-0345-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-010-0345-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>García Vicente, A. M.</creatorcontrib><creatorcontrib>Soriano Castrejón, A. M.</creatorcontrib><creatorcontrib>Talavera Rubio, M. P.</creatorcontrib><creatorcontrib>León Martín, A. A.</creatorcontrib><creatorcontrib>Palomar Muñoz, A. M.</creatorcontrib><creatorcontrib>Pilkington Woll, J. P.</creatorcontrib><creatorcontrib>Poblete García, V. M.</creatorcontrib><title>18F-FDG PET-CT respiratory gating in characterization of pulmonary lesions: approximation towards clinical indications</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>Aim
To evaluate the effect of the 18F-FDG PET-CT respiratory gating (4D) study in the correct documentation of pulmonary lesions with faint uptake in standard PET-CT.
Methods
Forty-two pulmonary lesions with a low or no detectable uptake of FDG (SUV
max
< 2.5) in 3D PET-CT were prospectively evaluated in 28 patients (19 males and 9 females), mean age 66.5 years (41–81). 22 patients had neoplastic background. A conventional PET-CT (3D) total body scan was performed approximately 60 min after iv injection of a mean dose of 370 MBq. Furthermore, a 4D PET-CT (synchronized with respiratory movement) thorax study was acquired. SUV
max
was determined for each lesion in both studies. For the 4D studies, we selected the SUV
max
in respiratory period with the highest uptake (“best bin”). We calculated the SUV
max
percentage difference between 3D and 4D PET-CT (% difference = SUV
max
4D − SUV
max
3D/SUV
max
3D × 100) and the relation of this value with the size and locations of the lesions. In 4D study, any lesion with SUV
max
≥ 2.5 was classified as malignant. We assessed the changes of lesion classification (from benign to malignant) applying the 4D technique. The final diagnosis was obtained by histological assessment or clinical and radiological follow-up longer than 12 months.
Results
Forty out of 42 lesions showed an increase of SUV
max
in the 4D study with respect to 3D. The mean SUV
max
in the 3D and 4D PET-CT studies were 1.33 (±0.59) and 2.26 (±0.87), respectively. The SUV
max
percentage difference mean between both techniques was 83.3% (±80.81).The smaller the lesion the greater was the SUV
max
percentage difference (
P
< 0.05). No differences were observed depending on the location of the lesion. In 40% of cases, there was a change in the final classification of lesions from benign to malignant. In the final diagnosis, 24 lesions were malignant. 4D PET-CT diagnosed correctly the 52% of them.
Conclusions
The 4D PET-CT study permitted a better characterization of malignant lung lesions compared with the standard PET-CT, because of its higher sensitivity. 4D PET-CT is a recommendable technique in the early diagnosis of malignant lesions.</description><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Radiology</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kEFPAyEQhYnRxFr9Ad6IdxRYYFlvprbVxEQP9UymFOo222WFrVp_vTRr4snTJDPfezPzELpk9JpRWt4kxpmoCGWU0EJIwo_QiGkliBJFcYxGtGKClEyXp-gspQ2lXEvNR-iD6RmZ3c_xy3RBJgscXerqCH2Ie7yGvm7XuG6xfYMItnex_s690OLgcbdrtqGFzDUu5V66xdB1MXzV24HpwyfEVcK2qdvaQpONVrkeZukcnXhokrv4rWP0OpsuJg_k6Xn-OLl7IpZLyglj0lbcF9IXUIJ3q5K6SqmlE1xRvRTlshB5oDkXJQgvAEBRClpaX9lK2mKMrgbffNj7zqXebMIutnml4UxSoaSqMsQGyMaQUnTedDE_EfeGUXNI1wzpmpyuOaRreNbwQZMy265d_DP-X_QDyPd-Cg</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>García Vicente, A. M.</creator><creator>Soriano Castrejón, A. M.</creator><creator>Talavera Rubio, M. P.</creator><creator>León Martín, A. A.</creator><creator>Palomar Muñoz, A. M.</creator><creator>Pilkington Woll, J. P.</creator><creator>Poblete García, V. M.</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20100401</creationdate><title>18F-FDG PET-CT respiratory gating in characterization of pulmonary lesions: approximation towards clinical indications</title><author>García Vicente, A. M. ; Soriano Castrejón, A. M. ; Talavera Rubio, M. P. ; León Martín, A. A. ; Palomar Muñoz, A. M. ; Pilkington Woll, J. P. ; Poblete García, V. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2502-115c92f35f3a7afed70e966be42608b47b34a7a82247a4f4aaa600a85cf9c95c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Radiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García Vicente, A. M.</creatorcontrib><creatorcontrib>Soriano Castrejón, A. M.</creatorcontrib><creatorcontrib>Talavera Rubio, M. P.</creatorcontrib><creatorcontrib>León Martín, A. A.</creatorcontrib><creatorcontrib>Palomar Muñoz, A. M.</creatorcontrib><creatorcontrib>Pilkington Woll, J. P.</creatorcontrib><creatorcontrib>Poblete García, V. M.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García Vicente, A. M.</au><au>Soriano Castrejón, A. M.</au><au>Talavera Rubio, M. P.</au><au>León Martín, A. A.</au><au>Palomar Muñoz, A. M.</au><au>Pilkington Woll, J. P.</au><au>Poblete García, V. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18F-FDG PET-CT respiratory gating in characterization of pulmonary lesions: approximation towards clinical indications</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><date>2010-04-01</date><risdate>2010</risdate><volume>24</volume><issue>3</issue><spage>207</spage><epage>214</epage><pages>207-214</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Aim
To evaluate the effect of the 18F-FDG PET-CT respiratory gating (4D) study in the correct documentation of pulmonary lesions with faint uptake in standard PET-CT.
Methods
Forty-two pulmonary lesions with a low or no detectable uptake of FDG (SUV
max
< 2.5) in 3D PET-CT were prospectively evaluated in 28 patients (19 males and 9 females), mean age 66.5 years (41–81). 22 patients had neoplastic background. A conventional PET-CT (3D) total body scan was performed approximately 60 min after iv injection of a mean dose of 370 MBq. Furthermore, a 4D PET-CT (synchronized with respiratory movement) thorax study was acquired. SUV
max
was determined for each lesion in both studies. For the 4D studies, we selected the SUV
max
in respiratory period with the highest uptake (“best bin”). We calculated the SUV
max
percentage difference between 3D and 4D PET-CT (% difference = SUV
max
4D − SUV
max
3D/SUV
max
3D × 100) and the relation of this value with the size and locations of the lesions. In 4D study, any lesion with SUV
max
≥ 2.5 was classified as malignant. We assessed the changes of lesion classification (from benign to malignant) applying the 4D technique. The final diagnosis was obtained by histological assessment or clinical and radiological follow-up longer than 12 months.
Results
Forty out of 42 lesions showed an increase of SUV
max
in the 4D study with respect to 3D. The mean SUV
max
in the 3D and 4D PET-CT studies were 1.33 (±0.59) and 2.26 (±0.87), respectively. The SUV
max
percentage difference mean between both techniques was 83.3% (±80.81).The smaller the lesion the greater was the SUV
max
percentage difference (
P
< 0.05). No differences were observed depending on the location of the lesion. In 40% of cases, there was a change in the final classification of lesions from benign to malignant. In the final diagnosis, 24 lesions were malignant. 4D PET-CT diagnosed correctly the 52% of them.
Conclusions
The 4D PET-CT study permitted a better characterization of malignant lung lesions compared with the standard PET-CT, because of its higher sensitivity. 4D PET-CT is a recommendable technique in the early diagnosis of malignant lesions.</abstract><cop>Japan</cop><pub>Springer Japan</pub><doi>10.1007/s12149-010-0345-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Imaging Medicine Medicine & Public Health Nuclear Medicine Original Article Radiology |
| title | 18F-FDG PET-CT respiratory gating in characterization of pulmonary lesions: approximation towards clinical indications |
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