Assessment of myocardial sympathetic innervation by PET in patients with heart failure: a review of the most recent advances and future perspectives
Purpose Life-threatening ventricular arrhythmias (VA) are a major cause of death in patients with congestive heart failure (HF). Among various factors, the sympathetic nervous system may give rise to VA in several pathophysiological pathways due to an impaired function of presynaptic sympathetic ner...
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| Veröffentlicht in: | Clinical and translational imaging : reviews in nuclear medicine and molecular imaging 2018-12, Vol.6 (6), p.459-470 |
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| creator | Popescu, Cristina Elena Cuzzocrea, Marco Monaco, Lavinia Caobelli, Federico |
| description | Purpose
Life-threatening ventricular arrhythmias (VA) are a major cause of death in patients with congestive heart failure (HF). Among various factors, the sympathetic nervous system may give rise to VA in several pathophysiological pathways due to an impaired function of presynaptic sympathetic nerve terminals. Positron emission tomography (PET) with labeled catecholamine analogues represents a reliable tool to assess the sympathetic innervation activity. This review aims at summarising the most relevant and recent literature findings on the current role of PET in the evaluation of cardiac sympathetic activity in patients with heart failure.
Methods and Results
A comprehensive literature search strategy using PubMed databases was carried out looking for articles on the role of Positron emission tomography/Computed Tomography (PET/CT) in the assessment of myocardial sympathetic innervation in patients with heart failure. The literature search limited to the last 5 years retrieved 40 papers. Most of the papers dealt with PET studies with
11
C-HED. 19 pre-clinical, first-in-human and clinical studies highlighting the current role of PET and future perspectives resulted eligible for inclusion in the present review.
Conclusion
The assessment of myocardial sympathetic activity in patients with heart failure with PET will play a pivotal role in clinical practice. Its capability to predict the occurrence of life-threatening VA and the effectiveness of resynchronization therapy makes this technique ideal in the era of personalized medicine. |
| doi_str_mv | 10.1007/s40336-018-0293-8 |
| format | Article |
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Life-threatening ventricular arrhythmias (VA) are a major cause of death in patients with congestive heart failure (HF). Among various factors, the sympathetic nervous system may give rise to VA in several pathophysiological pathways due to an impaired function of presynaptic sympathetic nerve terminals. Positron emission tomography (PET) with labeled catecholamine analogues represents a reliable tool to assess the sympathetic innervation activity. This review aims at summarising the most relevant and recent literature findings on the current role of PET in the evaluation of cardiac sympathetic activity in patients with heart failure.
Methods and Results
A comprehensive literature search strategy using PubMed databases was carried out looking for articles on the role of Positron emission tomography/Computed Tomography (PET/CT) in the assessment of myocardial sympathetic innervation in patients with heart failure. The literature search limited to the last 5 years retrieved 40 papers. Most of the papers dealt with PET studies with
11
C-HED. 19 pre-clinical, first-in-human and clinical studies highlighting the current role of PET and future perspectives resulted eligible for inclusion in the present review.
Conclusion
The assessment of myocardial sympathetic activity in patients with heart failure with PET will play a pivotal role in clinical practice. Its capability to predict the occurrence of life-threatening VA and the effectiveness of resynchronization therapy makes this technique ideal in the era of personalized medicine.</description><identifier>ISSN: 2281-5872</identifier><identifier>EISSN: 2281-7565</identifier><identifier>DOI: 10.1007/s40336-018-0293-8</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Beta blockers ; Cardiovascular ; Catecholamine ; Computed tomography ; Diagnostic Radiology ; Emission analysis ; Heart ; Heart failure ; Imaging ; Interventional Radiology ; Medical and Radiation Physics ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Patients ; Positron emission ; Radiology ; Radiotherapy ; Sympathetic nervous system ; Systematic Review ; Tomography</subject><ispartof>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging, 2018-12, Vol.6 (6), p.459-470</ispartof><rights>Italian Association of Nuclear Medicine and Molecular Imaging 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-a23132ffb83f78cc3cbdadb7f99355face009b0feffa0f87b452e5d17de163ba3</citedby><cites>FETCH-LOGICAL-c359t-a23132ffb83f78cc3cbdadb7f99355face009b0feffa0f87b452e5d17de163ba3</cites><orcidid>0000-0003-2472-775X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40336-018-0293-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40336-018-0293-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Popescu, Cristina Elena</creatorcontrib><creatorcontrib>Cuzzocrea, Marco</creatorcontrib><creatorcontrib>Monaco, Lavinia</creatorcontrib><creatorcontrib>Caobelli, Federico</creatorcontrib><title>Assessment of myocardial sympathetic innervation by PET in patients with heart failure: a review of the most recent advances and future perspectives</title><title>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging</title><addtitle>Clin Transl Imaging</addtitle><description>Purpose
Life-threatening ventricular arrhythmias (VA) are a major cause of death in patients with congestive heart failure (HF). Among various factors, the sympathetic nervous system may give rise to VA in several pathophysiological pathways due to an impaired function of presynaptic sympathetic nerve terminals. Positron emission tomography (PET) with labeled catecholamine analogues represents a reliable tool to assess the sympathetic innervation activity. This review aims at summarising the most relevant and recent literature findings on the current role of PET in the evaluation of cardiac sympathetic activity in patients with heart failure.
Methods and Results
A comprehensive literature search strategy using PubMed databases was carried out looking for articles on the role of Positron emission tomography/Computed Tomography (PET/CT) in the assessment of myocardial sympathetic innervation in patients with heart failure. The literature search limited to the last 5 years retrieved 40 papers. Most of the papers dealt with PET studies with
11
C-HED. 19 pre-clinical, first-in-human and clinical studies highlighting the current role of PET and future perspectives resulted eligible for inclusion in the present review.
Conclusion
The assessment of myocardial sympathetic activity in patients with heart failure with PET will play a pivotal role in clinical practice. Its capability to predict the occurrence of life-threatening VA and the effectiveness of resynchronization therapy makes this technique ideal in the era of personalized medicine.</description><subject>Beta blockers</subject><subject>Cardiovascular</subject><subject>Catecholamine</subject><subject>Computed tomography</subject><subject>Diagnostic Radiology</subject><subject>Emission analysis</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Medical and Radiation Physics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Radiology</subject><subject>Radiotherapy</subject><subject>Sympathetic nervous system</subject><subject>Systematic Review</subject><subject>Tomography</subject><issn>2281-5872</issn><issn>2281-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUhgdRULQP4C7gejSXpjPjTkq9QEEXdR3OZE5spHMxJ23pe_jApozgylXCOf_3H_iy7FrwW8F5cUdTrtQs56LMuaxUXp5kF1KWIi_0TJ_-_nVZyPNsQvTJORdcaCHERfb9QIRELXaR9Y61h95CaDxsGB3aAeIao7fMdx2GHUTfd6w-sLfFKo1YWvvEEdv7uGZrhBCZA7_ZBrxnwALuPO6PramFtT3FNLLHQ9DsoLNIDLqGuW1MABsw0IA2-h3SVXbmYEM4-X0vs_fHxWr-nC9fn17mD8vcKl3FHKQSSjpXl8oVpbXK1g00deGqSmntwCLnVc0dOgfclUU91RJ1I4oGxUzVoC6zm7F3CP3XFimaz34bunTSSDGtKp288ZQSY8qGniigM0PwLYSDEdwc_ZvRv0n-zdG_KRMjR4ZStvvA8Nf8P_QDsEGMPw</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Popescu, Cristina Elena</creator><creator>Cuzzocrea, Marco</creator><creator>Monaco, Lavinia</creator><creator>Caobelli, Federico</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-2472-775X</orcidid></search><sort><creationdate>20181201</creationdate><title>Assessment of myocardial sympathetic innervation by PET in patients with heart failure: a review of the most recent advances and future perspectives</title><author>Popescu, Cristina Elena ; Cuzzocrea, Marco ; Monaco, Lavinia ; Caobelli, Federico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-a23132ffb83f78cc3cbdadb7f99355face009b0feffa0f87b452e5d17de163ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Beta blockers</topic><topic>Cardiovascular</topic><topic>Catecholamine</topic><topic>Computed tomography</topic><topic>Diagnostic Radiology</topic><topic>Emission analysis</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Medical and Radiation Physics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Radiology</topic><topic>Radiotherapy</topic><topic>Sympathetic nervous system</topic><topic>Systematic Review</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popescu, Cristina Elena</creatorcontrib><creatorcontrib>Cuzzocrea, Marco</creatorcontrib><creatorcontrib>Monaco, Lavinia</creatorcontrib><creatorcontrib>Caobelli, Federico</creatorcontrib><collection>CrossRef</collection><jtitle>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popescu, Cristina Elena</au><au>Cuzzocrea, Marco</au><au>Monaco, Lavinia</au><au>Caobelli, Federico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of myocardial sympathetic innervation by PET in patients with heart failure: a review of the most recent advances and future perspectives</atitle><jtitle>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging</jtitle><stitle>Clin Transl Imaging</stitle><date>2018-12-01</date><risdate>2018</risdate><volume>6</volume><issue>6</issue><spage>459</spage><epage>470</epage><pages>459-470</pages><issn>2281-5872</issn><eissn>2281-7565</eissn><abstract>Purpose
Life-threatening ventricular arrhythmias (VA) are a major cause of death in patients with congestive heart failure (HF). Among various factors, the sympathetic nervous system may give rise to VA in several pathophysiological pathways due to an impaired function of presynaptic sympathetic nerve terminals. Positron emission tomography (PET) with labeled catecholamine analogues represents a reliable tool to assess the sympathetic innervation activity. This review aims at summarising the most relevant and recent literature findings on the current role of PET in the evaluation of cardiac sympathetic activity in patients with heart failure.
Methods and Results
A comprehensive literature search strategy using PubMed databases was carried out looking for articles on the role of Positron emission tomography/Computed Tomography (PET/CT) in the assessment of myocardial sympathetic innervation in patients with heart failure. The literature search limited to the last 5 years retrieved 40 papers. Most of the papers dealt with PET studies with
11
C-HED. 19 pre-clinical, first-in-human and clinical studies highlighting the current role of PET and future perspectives resulted eligible for inclusion in the present review.
Conclusion
The assessment of myocardial sympathetic activity in patients with heart failure with PET will play a pivotal role in clinical practice. Its capability to predict the occurrence of life-threatening VA and the effectiveness of resynchronization therapy makes this technique ideal in the era of personalized medicine.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40336-018-0293-8</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2472-775X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Beta blockers Cardiovascular Catecholamine Computed tomography Diagnostic Radiology Emission analysis Heart Heart failure Imaging Interventional Radiology Medical and Radiation Physics Medicine Medicine & Public Health Nuclear Medicine Patients Positron emission Radiology Radiotherapy Sympathetic nervous system Systematic Review Tomography |
| title | Assessment of myocardial sympathetic innervation by PET in patients with heart failure: a review of the most recent advances and future perspectives |
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