Warfarin Safety: A Cross-Sectional Study of the Factors Associated with the Consumption of Medicinal Plants in a Brazilian Anticoagulation Clinic
Objective The aim of this study was to analyze factors associated with the consumption of medicinal plants by patients being treated with warfarin in a Brazilian anticoagulation clinic and to study the safety of medicinal plant use in patients on warfarin therapy. Methods The study was performed as...
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| Veröffentlicht in: | American journal of cardiovascular drugs : drugs, devices, and other interventions devices, and other interventions, 2018-06, Vol.18 (3), p.231-243 |
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| creator | Leite, Paula Mendonça de Freitas, Aline A. Mourão, Aline de O. Magalhães Martins, Maria A. P. Castilho, Rachel O. |
| description | Objective
The aim of this study was to analyze factors associated with the consumption of medicinal plants by patients being treated with warfarin in a Brazilian anticoagulation clinic and to study the safety of medicinal plant use in patients on warfarin therapy.
Methods
The study was performed as an observational cross-sectional analysis. Study participants were outpatients on long-term warfarin therapy for at least 2 months for atrial fibrillation or prosthetic cardiac valves. Interviews were carried out concerning information about the habits of medicinal herb consumption, and logistic regression analysis was performed to identify factors associated with the consumption of herbs. The scientific names of the medicinal plants were identified to search for information on the effects on the hemostasis of the interactions between the medicinal herbs reported and warfarin.
Results
The mean age of the 273 patients included was 60.8 years; 58.7% were women. Medicinal plants were used by 67% of the participants. No association between demographic and clinical data and the use of medicinal plants was identified. Patients reported a total of 64 different plants, primarily consumed in the form of tea. The plants were mainly used to treat respiratory tract and central nervous system disorders. About 40% of the plants cited have been reported to potentially interfere with the anticoagulation therapy, principally by potentiating the effects of warfarin, which could, increase the risk of bleeding.
Conclusion
The use of medicinal plants was highly common and widespread in patients receiving warfarin as an anticoagulation therapy. Univariate analysis of variables associated with the consumption of herbs showed no statistically significant difference in the consumption of medicinal plants for any of the sociodemographic and clinical data. The medicinal plants that were reportedly consumed by the patients could affect hemostasis. This study reinforces the need for further studies evaluating the habits of patients consuming medicinal plants and their clinical implications, and will help to design strategies to manage the risks associated with warfarin-herbal interactions. |
| doi_str_mv | 10.1007/s40256-018-0268-1 |
| format | Article |
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The aim of this study was to analyze factors associated with the consumption of medicinal plants by patients being treated with warfarin in a Brazilian anticoagulation clinic and to study the safety of medicinal plant use in patients on warfarin therapy.
Methods
The study was performed as an observational cross-sectional analysis. Study participants were outpatients on long-term warfarin therapy for at least 2 months for atrial fibrillation or prosthetic cardiac valves. Interviews were carried out concerning information about the habits of medicinal herb consumption, and logistic regression analysis was performed to identify factors associated with the consumption of herbs. The scientific names of the medicinal plants were identified to search for information on the effects on the hemostasis of the interactions between the medicinal herbs reported and warfarin.
Results
The mean age of the 273 patients included was 60.8 years; 58.7% were women. Medicinal plants were used by 67% of the participants. No association between demographic and clinical data and the use of medicinal plants was identified. Patients reported a total of 64 different plants, primarily consumed in the form of tea. The plants were mainly used to treat respiratory tract and central nervous system disorders. About 40% of the plants cited have been reported to potentially interfere with the anticoagulation therapy, principally by potentiating the effects of warfarin, which could, increase the risk of bleeding.
Conclusion
The use of medicinal plants was highly common and widespread in patients receiving warfarin as an anticoagulation therapy. Univariate analysis of variables associated with the consumption of herbs showed no statistically significant difference in the consumption of medicinal plants for any of the sociodemographic and clinical data. The medicinal plants that were reportedly consumed by the patients could affect hemostasis. This study reinforces the need for further studies evaluating the habits of patients consuming medicinal plants and their clinical implications, and will help to design strategies to manage the risks associated with warfarin-herbal interactions.</description><identifier>ISSN: 1175-3277</identifier><identifier>EISSN: 1179-187X</identifier><identifier>DOI: 10.1007/s40256-018-0268-1</identifier><identifier>PMID: 29476459</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Anticoagulants ; Anticoagulants - adverse effects ; Anticoagulants - metabolism ; Brazil - epidemiology ; Cardiology ; Cross-Sectional Studies ; Drug therapy ; Female ; Hemostasis - drug effects ; Hemostasis - physiology ; Herb-Drug Interactions - physiology ; Herbal medicine ; Herbs ; Humans ; International Normalized Ratio - trends ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Natural products ; Original Research Article ; Outpatient Clinics, Hospital - trends ; Pharmacology/Toxicology ; Pharmacotherapy ; Plants, Medicinal - adverse effects ; Plants, Medicinal - metabolism ; Studies ; Warfarin - adverse effects ; Warfarin - metabolism</subject><ispartof>American journal of cardiovascular drugs : drugs, devices, and other interventions, 2018-06, Vol.18 (3), p.231-243</ispartof><rights>Springer International Publishing AG, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media Jun 2018</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-dc870b70bfa4886ff102890a4f24180000e90f7bc61f40ceda1ebf2cf4a2c6693</citedby><cites>FETCH-LOGICAL-c372t-dc870b70bfa4886ff102890a4f24180000e90f7bc61f40ceda1ebf2cf4a2c6693</cites><orcidid>0000-0002-8499-5791</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40256-018-0268-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40256-018-0268-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29476459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leite, Paula Mendonça</creatorcontrib><creatorcontrib>de Freitas, Aline A.</creatorcontrib><creatorcontrib>Mourão, Aline de O. Magalhães</creatorcontrib><creatorcontrib>Martins, Maria A. P.</creatorcontrib><creatorcontrib>Castilho, Rachel O.</creatorcontrib><title>Warfarin Safety: A Cross-Sectional Study of the Factors Associated with the Consumption of Medicinal Plants in a Brazilian Anticoagulation Clinic</title><title>American journal of cardiovascular drugs : drugs, devices, and other interventions</title><addtitle>Am J Cardiovasc Drugs</addtitle><addtitle>Am J Cardiovasc Drugs</addtitle><description>Objective
The aim of this study was to analyze factors associated with the consumption of medicinal plants by patients being treated with warfarin in a Brazilian anticoagulation clinic and to study the safety of medicinal plant use in patients on warfarin therapy.
Methods
The study was performed as an observational cross-sectional analysis. Study participants were outpatients on long-term warfarin therapy for at least 2 months for atrial fibrillation or prosthetic cardiac valves. Interviews were carried out concerning information about the habits of medicinal herb consumption, and logistic regression analysis was performed to identify factors associated with the consumption of herbs. The scientific names of the medicinal plants were identified to search for information on the effects on the hemostasis of the interactions between the medicinal herbs reported and warfarin.
Results
The mean age of the 273 patients included was 60.8 years; 58.7% were women. Medicinal plants were used by 67% of the participants. No association between demographic and clinical data and the use of medicinal plants was identified. Patients reported a total of 64 different plants, primarily consumed in the form of tea. The plants were mainly used to treat respiratory tract and central nervous system disorders. About 40% of the plants cited have been reported to potentially interfere with the anticoagulation therapy, principally by potentiating the effects of warfarin, which could, increase the risk of bleeding.
Conclusion
The use of medicinal plants was highly common and widespread in patients receiving warfarin as an anticoagulation therapy. Univariate analysis of variables associated with the consumption of herbs showed no statistically significant difference in the consumption of medicinal plants for any of the sociodemographic and clinical data. The medicinal plants that were reportedly consumed by the patients could affect hemostasis. This study reinforces the need for further studies evaluating the habits of patients consuming medicinal plants and their clinical implications, and will help to design strategies to manage the risks associated with warfarin-herbal interactions.</description><subject>Aged</subject><subject>Anticoagulants</subject><subject>Anticoagulants - adverse effects</subject><subject>Anticoagulants - metabolism</subject><subject>Brazil - epidemiology</subject><subject>Cardiology</subject><subject>Cross-Sectional Studies</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Hemostasis - drug effects</subject><subject>Hemostasis - physiology</subject><subject>Herb-Drug Interactions - physiology</subject><subject>Herbal medicine</subject><subject>Herbs</subject><subject>Humans</subject><subject>International Normalized Ratio - trends</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Natural products</subject><subject>Original Research Article</subject><subject>Outpatient Clinics, Hospital - trends</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacotherapy</subject><subject>Plants, Medicinal - adverse effects</subject><subject>Plants, Medicinal - metabolism</subject><subject>Studies</subject><subject>Warfarin - adverse effects</subject><subject>Warfarin - metabolism</subject><issn>1175-3277</issn><issn>1179-187X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kdFqHCEUhqU0NGnaB-hNEXJtq66rTu82Q9MWEhLYlPZOzjqaGGbHjTqUzVvkjePsps1VRfDA-f7_yPkR-sDoJ0ap-pwF5XNJKNOEcqkJe4WOGFMNYVr9fr2r52TGlTpEb3O-o5Qprpo36JA3Qkkxb47Q4y9IHlIY8BK8K9sveIHbFHMmS2dLiAP0eFnGboujx-XW4TOwJaaMFzlHG6C4Dv8J5XbXa-OQx_Vmkk34heuCDZPDVQ9DybhOAXya4CH0AQa8GEqwEW7GHnaStg9DsO_QgYc-u_fP7zH6efb1uv1Ozi-__WgX58TOFC-ks1rRVb0ehNbSe0a5bigIzwXTtB7XUK9WVjIvqHUdMLfy3HoB3ErZzI7Ryd53k-L96HIxd3FM9bfZcCYayanUulJsT9lpKcl5s0lhDWlrGDVTCGYfgqkhmCkEw6rm47PzuFq77p_i79YrwPdArq3hxqWX0f93fQIBNJPD</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Leite, Paula Mendonça</creator><creator>de Freitas, Aline A.</creator><creator>Mourão, Aline de O. Magalhães</creator><creator>Martins, Maria A. P.</creator><creator>Castilho, Rachel O.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-8499-5791</orcidid></search><sort><creationdate>20180601</creationdate><title>Warfarin Safety: A Cross-Sectional Study of the Factors Associated with the Consumption of Medicinal Plants in a Brazilian Anticoagulation Clinic</title><author>Leite, Paula Mendonça ; de Freitas, Aline A. ; Mourão, Aline de O. Magalhães ; Martins, Maria A. P. ; Castilho, Rachel O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-dc870b70bfa4886ff102890a4f24180000e90f7bc61f40ceda1ebf2cf4a2c6693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Anticoagulants</topic><topic>Anticoagulants - adverse effects</topic><topic>Anticoagulants - metabolism</topic><topic>Brazil - epidemiology</topic><topic>Cardiology</topic><topic>Cross-Sectional Studies</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Hemostasis - drug effects</topic><topic>Hemostasis - physiology</topic><topic>Herb-Drug Interactions - physiology</topic><topic>Herbal medicine</topic><topic>Herbs</topic><topic>Humans</topic><topic>International Normalized Ratio - trends</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Natural products</topic><topic>Original Research Article</topic><topic>Outpatient Clinics, Hospital - trends</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacotherapy</topic><topic>Plants, Medicinal - adverse effects</topic><topic>Plants, Medicinal - metabolism</topic><topic>Studies</topic><topic>Warfarin - adverse effects</topic><topic>Warfarin - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Leite, Paula Mendonça</creatorcontrib><creatorcontrib>de Freitas, Aline A.</creatorcontrib><creatorcontrib>Mourão, Aline de O. Magalhães</creatorcontrib><creatorcontrib>Martins, Maria A. 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Magalhães</au><au>Martins, Maria A. P.</au><au>Castilho, Rachel O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Warfarin Safety: A Cross-Sectional Study of the Factors Associated with the Consumption of Medicinal Plants in a Brazilian Anticoagulation Clinic</atitle><jtitle>American journal of cardiovascular drugs : drugs, devices, and other interventions</jtitle><stitle>Am J Cardiovasc Drugs</stitle><addtitle>Am J Cardiovasc Drugs</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>18</volume><issue>3</issue><spage>231</spage><epage>243</epage><pages>231-243</pages><issn>1175-3277</issn><eissn>1179-187X</eissn><abstract>Objective
The aim of this study was to analyze factors associated with the consumption of medicinal plants by patients being treated with warfarin in a Brazilian anticoagulation clinic and to study the safety of medicinal plant use in patients on warfarin therapy.
Methods
The study was performed as an observational cross-sectional analysis. Study participants were outpatients on long-term warfarin therapy for at least 2 months for atrial fibrillation or prosthetic cardiac valves. Interviews were carried out concerning information about the habits of medicinal herb consumption, and logistic regression analysis was performed to identify factors associated with the consumption of herbs. The scientific names of the medicinal plants were identified to search for information on the effects on the hemostasis of the interactions between the medicinal herbs reported and warfarin.
Results
The mean age of the 273 patients included was 60.8 years; 58.7% were women. Medicinal plants were used by 67% of the participants. No association between demographic and clinical data and the use of medicinal plants was identified. Patients reported a total of 64 different plants, primarily consumed in the form of tea. The plants were mainly used to treat respiratory tract and central nervous system disorders. About 40% of the plants cited have been reported to potentially interfere with the anticoagulation therapy, principally by potentiating the effects of warfarin, which could, increase the risk of bleeding.
Conclusion
The use of medicinal plants was highly common and widespread in patients receiving warfarin as an anticoagulation therapy. Univariate analysis of variables associated with the consumption of herbs showed no statistically significant difference in the consumption of medicinal plants for any of the sociodemographic and clinical data. The medicinal plants that were reportedly consumed by the patients could affect hemostasis. This study reinforces the need for further studies evaluating the habits of patients consuming medicinal plants and their clinical implications, and will help to design strategies to manage the risks associated with warfarin-herbal interactions.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29476459</pmid><doi>10.1007/s40256-018-0268-1</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8499-5791</orcidid></addata></record> |
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| subjects | Aged Anticoagulants Anticoagulants - adverse effects Anticoagulants - metabolism Brazil - epidemiology Cardiology Cross-Sectional Studies Drug therapy Female Hemostasis - drug effects Hemostasis - physiology Herb-Drug Interactions - physiology Herbal medicine Herbs Humans International Normalized Ratio - trends Male Medicine Medicine & Public Health Middle Aged Natural products Original Research Article Outpatient Clinics, Hospital - trends Pharmacology/Toxicology Pharmacotherapy Plants, Medicinal - adverse effects Plants, Medicinal - metabolism Studies Warfarin - adverse effects Warfarin - metabolism |
| title | Warfarin Safety: A Cross-Sectional Study of the Factors Associated with the Consumption of Medicinal Plants in a Brazilian Anticoagulation Clinic |
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