Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ.801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain

Background ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation in clinical development for Alzheimer's disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestinal tolerability. During clinical studies, we disc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	CNS drugs 2018-09, Vol.32 (9), p.849-861
Hauptverfasser:	Hey, John A, Kocis, Petr, Hort, Jakub, Abushakra, Susan, Power, Aidan, Vyhnálek, Martin, Yu, Jeremy Y, Tolar, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Apolipoprotein E Apolipoproteins Bioavailability Biomarkers Blood-brain barrier Brain Central nervous system Cerebrospinal fluid Chromatography Cognitive ability Drug dosages E protein Geriatrics Intravenous administration Liquid chromatography Mass spectrometry Mass spectroscopy Memory Monomers Nervous system Neurodegenerative diseases Oral administration Peptides Pharmacokinetics Proteins Scientific imaging Urine β-Amyloid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!