Serum Cotinine as a Marker of Environmental Tobacco Smoke Exposure in Epidemiological Studies: The Experience of the MATISS Project
To describe serum cotinine levels in a rural Italian population and to examine its usefulness as an epidemiologic biomarker of nicotine exposure, cross-sectional data collected in 1993 for the MATISS Project (2098 men and 1352 women, aged 20-79 years) were used. The study population consisted of 977...
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| Veröffentlicht in: | European journal of epidemiology 2003-01, Vol.18 (6), p.487-492 |
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| container_title | European journal of epidemiology |
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| creator | Seccareccia, F. Zuccaro, P. Pacifici, R. Meli, P. Pannozzo, F. Freeman, K. M. Santaquilani, A. Giampaoli, S. Research Group of the MATISS Project |
| description | To describe serum cotinine levels in a rural Italian population and to examine its usefulness as an epidemiologic biomarker of nicotine exposure, cross-sectional data collected in 1993 for the MATISS Project (2098 men and 1352 women, aged 20-79 years) were used. The study population consisted of 977 current smokers, 882 nonsmokers reporting exposure to environmental tobacco smoke (ETS) and 1520 nonsmokers reporting no ETS exposure. Mean values of serum cotinine measured by radioimmunoassay for never smokers, ex-smokers and current smokers (including four categories of cigarette consumption), and for categories of ETS exposure in all nonsmokers were calculated. In univariate analysis, there was a positive association between self-reported nicotine exposure and serum cotinine levels in all groups. Using self-reported status as truth, sensitivity and specificity for various cotinine cutoff points were estimated to distinguish nonsmokers from smokers. The value of 15 ng/mL represented the best combined levels of sensitivity (95%) and specificity (96%). Using this cutoff point, the overall misclassification rate for self-reported nonsmokers was 2.1% and about two times greater for the more vs. the less educated. In multivariate analysis, reported ETS exposure among nonsmokers was significantly associated with serum cotinine even after adjusting for age, socio-demographic and behavioural factors, though the strength of the association was not strong. In conclusion, serum cotinine represents a reliable epidemiological marker of nicotine intake and may be helpful when studying ETS exposure. Improved information collection is needed to reduce misclassification among nonsmokers and enhance our understanding of the relationship between ETS and cotinine measures. |
| doi_str_mv | 10.1023/a:1024672522802 |
| format | Article |
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M. ; Santaquilani, A. ; Giampaoli, S. ; Research Group of the MATISS Project</creator><creatorcontrib>Seccareccia, F. ; Zuccaro, P. ; Pacifici, R. ; Meli, P. ; Pannozzo, F. ; Freeman, K. M. ; Santaquilani, A. ; Giampaoli, S. ; Research Group of the MATISS Project ; Research Group of the MATISS Project</creatorcontrib><description>To describe serum cotinine levels in a rural Italian population and to examine its usefulness as an epidemiologic biomarker of nicotine exposure, cross-sectional data collected in 1993 for the MATISS Project (2098 men and 1352 women, aged 20-79 years) were used. The study population consisted of 977 current smokers, 882 nonsmokers reporting exposure to environmental tobacco smoke (ETS) and 1520 nonsmokers reporting no ETS exposure. Mean values of serum cotinine measured by radioimmunoassay for never smokers, ex-smokers and current smokers (including four categories of cigarette consumption), and for categories of ETS exposure in all nonsmokers were calculated. In univariate analysis, there was a positive association between self-reported nicotine exposure and serum cotinine levels in all groups. Using self-reported status as truth, sensitivity and specificity for various cotinine cutoff points were estimated to distinguish nonsmokers from smokers. The value of 15 ng/mL represented the best combined levels of sensitivity (95%) and specificity (96%). Using this cutoff point, the overall misclassification rate for self-reported nonsmokers was 2.1% and about two times greater for the more vs. the less educated. In multivariate analysis, reported ETS exposure among nonsmokers was significantly associated with serum cotinine even after adjusting for age, socio-demographic and behavioural factors, though the strength of the association was not strong. In conclusion, serum cotinine represents a reliable epidemiological marker of nicotine intake and may be helpful when studying ETS exposure. Improved information collection is needed to reduce misclassification among nonsmokers and enhance our understanding of the relationship between ETS and cotinine measures.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1023/a:1024672522802</identifier><identifier>PMID: 12908713</identifier><identifier>CODEN: EJEPE8</identifier><language>eng</language><publisher>Dordrecht: Kluwer Academic Publishers</publisher><subject>Adult ; Aged ; Anti smoking movements ; Biological and medical sciences ; Biological markers ; Biomarkers - blood ; Cigar smoking ; Cigarette smoking ; Cigarettes ; Cotinine - blood ; Cross-Sectional Studies ; Data collection ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Epidemiology ; Exposure ; Female ; Food ; Humans ; Italy - epidemiology ; Male ; Medical sciences ; Methods ; Middle Aged ; Multivariate analysis ; Nicotine ; Nicotine - blood ; Passive smoking ; Questionnaires ; Radioimmunoassay ; Secondhand smoke ; Smoking - epidemiology ; Smoking - immunology ; Smoking cessation ; Studies ; Tobacco ; Tobacco smoke ; Tobacco Smoke Pollution - analysis ; Tobacco smoking ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>European journal of epidemiology, 2003-01, Vol.18 (6), p.487-492</ispartof><rights>Copyright 2003 Kluwer Academic Publishers</rights><rights>2003 INIST-CNRS</rights><rights>Copyright (c) 2003 Kluwer Academic Publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-eb98dc2c4630224ae6da7f6cdc371d52e3faade2a308a9122d44d3e99ffb72ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3582900$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3582900$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14942912$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12908713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seccareccia, F.</creatorcontrib><creatorcontrib>Zuccaro, P.</creatorcontrib><creatorcontrib>Pacifici, R.</creatorcontrib><creatorcontrib>Meli, P.</creatorcontrib><creatorcontrib>Pannozzo, F.</creatorcontrib><creatorcontrib>Freeman, K. M.</creatorcontrib><creatorcontrib>Santaquilani, A.</creatorcontrib><creatorcontrib>Giampaoli, S.</creatorcontrib><creatorcontrib>Research Group of the MATISS Project</creatorcontrib><creatorcontrib>Research Group of the MATISS Project</creatorcontrib><title>Serum Cotinine as a Marker of Environmental Tobacco Smoke Exposure in Epidemiological Studies: The Experience of the MATISS Project</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><description>To describe serum cotinine levels in a rural Italian population and to examine its usefulness as an epidemiologic biomarker of nicotine exposure, cross-sectional data collected in 1993 for the MATISS Project (2098 men and 1352 women, aged 20-79 years) were used. The study population consisted of 977 current smokers, 882 nonsmokers reporting exposure to environmental tobacco smoke (ETS) and 1520 nonsmokers reporting no ETS exposure. Mean values of serum cotinine measured by radioimmunoassay for never smokers, ex-smokers and current smokers (including four categories of cigarette consumption), and for categories of ETS exposure in all nonsmokers were calculated. In univariate analysis, there was a positive association between self-reported nicotine exposure and serum cotinine levels in all groups. Using self-reported status as truth, sensitivity and specificity for various cotinine cutoff points were estimated to distinguish nonsmokers from smokers. The value of 15 ng/mL represented the best combined levels of sensitivity (95%) and specificity (96%). Using this cutoff point, the overall misclassification rate for self-reported nonsmokers was 2.1% and about two times greater for the more vs. the less educated. In multivariate analysis, reported ETS exposure among nonsmokers was significantly associated with serum cotinine even after adjusting for age, socio-demographic and behavioural factors, though the strength of the association was not strong. In conclusion, serum cotinine represents a reliable epidemiological marker of nicotine intake and may be helpful when studying ETS exposure. Improved information collection is needed to reduce misclassification among nonsmokers and enhance our understanding of the relationship between ETS and cotinine measures.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti smoking movements</subject><subject>Biological and medical sciences</subject><subject>Biological markers</subject><subject>Biomarkers - blood</subject><subject>Cigar smoking</subject><subject>Cigarette smoking</subject><subject>Cigarettes</subject><subject>Cotinine - blood</subject><subject>Cross-Sectional Studies</subject><subject>Data collection</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Food</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nicotine</subject><subject>Nicotine - blood</subject><subject>Passive smoking</subject><subject>Questionnaires</subject><subject>Radioimmunoassay</subject><subject>Secondhand smoke</subject><subject>Smoking - epidemiology</subject><subject>Smoking - immunology</subject><subject>Smoking cessation</subject><subject>Studies</subject><subject>Tobacco</subject><subject>Tobacco smoke</subject><subject>Tobacco Smoke Pollution - analysis</subject><subject>Tobacco smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0393-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpV0M1rHCEYBnApKc0m7bmXEKSQ4zT66nyY27Js00BCC7M9D66-07rZ0Y3OlObcfzwmuzT09KL-fJSHkI-cfeYMxKW-ykNWNZQADYM3ZMbLWhQ1NPKIzJhQogCl2DE5SWnDGGuYKt-RYw6KNTUXM_K3xTgNdBFG551HqhPV9E7He4w09HTpf7sY_IB-1Fu6CmttTKDtEO6RLv_sQpoiUufpcucsDi5sw09nsmzHyTpMV3T16wVidOgNPkeOeeduvrppW_o9hg2a8T152-ttwg-HeUp-fFmuFl-L22_XN4v5bWFkVY0FrlVjDeSFYABSY2V13VfGGlFzWwKKXmuLoAVrtOIAVkorUKm-X9egrTgln_a5uxgeJkxjtwlT9PnJDrhsKlVWMqPLPTIxpBSx73bRDTo-dpx1z5138-6_zvON80PstB7QvvpDyRlcHIBOuZw-am9cenVSScj_ze5s7zZpDPHfuSibnMTEEx-Lk0E</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Seccareccia, F.</creator><creator>Zuccaro, P.</creator><creator>Pacifici, R.</creator><creator>Meli, P.</creator><creator>Pannozzo, F.</creator><creator>Freeman, K. 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M.</au><au>Santaquilani, A.</au><au>Giampaoli, S.</au><au>Research Group of the MATISS Project</au><aucorp>Research Group of the MATISS Project</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Cotinine as a Marker of Environmental Tobacco Smoke Exposure in Epidemiological Studies: The Experience of the MATISS Project</atitle><jtitle>European journal of epidemiology</jtitle><addtitle>Eur J Epidemiol</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>18</volume><issue>6</issue><spage>487</spage><epage>492</epage><pages>487-492</pages><issn>0393-2990</issn><eissn>1573-7284</eissn><coden>EJEPE8</coden><abstract>To describe serum cotinine levels in a rural Italian population and to examine its usefulness as an epidemiologic biomarker of nicotine exposure, cross-sectional data collected in 1993 for the MATISS Project (2098 men and 1352 women, aged 20-79 years) were used. The study population consisted of 977 current smokers, 882 nonsmokers reporting exposure to environmental tobacco smoke (ETS) and 1520 nonsmokers reporting no ETS exposure. Mean values of serum cotinine measured by radioimmunoassay for never smokers, ex-smokers and current smokers (including four categories of cigarette consumption), and for categories of ETS exposure in all nonsmokers were calculated. In univariate analysis, there was a positive association between self-reported nicotine exposure and serum cotinine levels in all groups. Using self-reported status as truth, sensitivity and specificity for various cotinine cutoff points were estimated to distinguish nonsmokers from smokers. The value of 15 ng/mL represented the best combined levels of sensitivity (95%) and specificity (96%). Using this cutoff point, the overall misclassification rate for self-reported nonsmokers was 2.1% and about two times greater for the more vs. the less educated. In multivariate analysis, reported ETS exposure among nonsmokers was significantly associated with serum cotinine even after adjusting for age, socio-demographic and behavioural factors, though the strength of the association was not strong. In conclusion, serum cotinine represents a reliable epidemiological marker of nicotine intake and may be helpful when studying ETS exposure. Improved information collection is needed to reduce misclassification among nonsmokers and enhance our understanding of the relationship between ETS and cotinine measures.</abstract><cop>Dordrecht</cop><pub>Kluwer Academic Publishers</pub><pmid>12908713</pmid><doi>10.1023/a:1024672522802</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of epidemiology, 2003-01, Vol.18 (6), p.487-492 |
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| subjects | Adult Aged Anti smoking movements Biological and medical sciences Biological markers Biomarkers - blood Cigar smoking Cigarette smoking Cigarettes Cotinine - blood Cross-Sectional Studies Data collection Environmental Exposure - adverse effects Environmental Exposure - analysis Epidemiology Exposure Female Food Humans Italy - epidemiology Male Medical sciences Methods Middle Aged Multivariate analysis Nicotine Nicotine - blood Passive smoking Questionnaires Radioimmunoassay Secondhand smoke Smoking - epidemiology Smoking - immunology Smoking cessation Studies Tobacco Tobacco smoke Tobacco Smoke Pollution - analysis Tobacco smoking Tobacco, tobacco smoking Toxicology |
| title | Serum Cotinine as a Marker of Environmental Tobacco Smoke Exposure in Epidemiological Studies: The Experience of the MATISS Project |
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