Coagulant Effect and Tolerability of Yeast-Produced Recombinant Batroxobin in Healthy Adult Subjects

Background and Objective Batroxobin, a snake venom thrombin-like enzyme, converts fibrinogen into fibrin by cleaving fibrinopeptide A. It is used for hemostasis; however, the supply of native batroxobin is limited. Therefore, we developed a recombinant batroxobin (r-batroxobin) from Pichia pastoris...

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Veröffentlicht in:	Clinical drug investigation 2018-09, Vol.38 (9), p.829-835
Hauptverfasser:	Choi, Seuk Keun, Kim, Chan Wha, Kim, Jong-Tak, Seomun, Young, Park, Min Soo, Kim, Choon Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino acids Batroxobin - administration & dosage Batroxobin - blood Blood Coagulation - drug effects Blood Coagulation - physiology Blood transfusions Cohort Studies Dose-Response Relationship, Drug Double-Blind Method Drug dosages Enzymes Healthy Volunteers Hemophilia Hemostatics - administration & dosage Hemostatics - blood Hepatitis Humans Injections, Intravenous Internal Medicine Male Medicine Medicine & Public Health Middle Aged Original Research Article Pharmacology/Toxicology Pharmacotherapy Prothrombin Time - methods Recombinant Proteins - administration & dosage Surgery Thrombin - metabolism Trauma Venom Young Adult
Online-Zugang:	Volltext
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