Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone

Preliminary in vitro findings indicated that the novel anxiolytic drug, deramciclane is a substrate for the cytochrome P(450) (CYP) 3A4 isoenzyme. Moreover, its co-administration with buspirone, another anxiolytic drug, is likely in clinical practice. The primary objective of the present study was t...

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Veröffentlicht in:	European journal of clinical pharmacology 2003-12, Vol.59 (10), p.761-766
Hauptverfasser:	LAINE, Kari, AHOKOSKI, Outi, HUUPPONEN, Risto, HÄNNINEN, Jutta, PALOVAARA, Sanna, RUUSKANEN, Jori, BJÖRKLUND, Harry, ANTTILA, Markku, ROURU, Juha
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Anti-Anxiety Agents - pharmacology Area Under Curve Biological and medical sciences Bornanes - pharmacology Buspirone - analogs & derivatives Buspirone - blood Buspirone - pharmacokinetics Buspirone - pharmacology Cross-Over Studies Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Double-Blind Method Drug Interactions Female Half-Life Humans Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Time Factors
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