Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats
Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazo...
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| Veröffentlicht in: | Digestive diseases and sciences 2000-07, Vol.45 (7), p.1439-1443 |
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| creator | FURNE, J. K SUAREZ, F. L EWING, S. L SPRINGFIELD, J LEVITT, M. D |
| description | Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis. |
| doi_str_mv | 10.1023/A:1005580709390 |
| format | Article |
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K ; SUAREZ, F. L ; EWING, S. L ; SPRINGFIELD, J ; LEVITT, M. D</creator><creatorcontrib>FURNE, J. K ; SUAREZ, F. L ; EWING, S. L ; SPRINGFIELD, J ; LEVITT, M. D</creatorcontrib><description>Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1005580709390</identifier><identifier>PMID: 10961726</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Bismuth - metabolism ; Bismuth - pharmacology ; Colitis - chemically induced ; Colitis - metabolism ; Colitis - pathology ; Colitis - prevention & control ; Colon - pathology ; Dextran Sulfate ; Feces - chemistry ; Gastroenterology. Liver. Pancreas. Abdomen ; Hydrogen Sulfide - antagonists & inhibitors ; Hydrogen Sulfide - metabolism ; Male ; Medical sciences ; Organometallic Compounds - metabolism ; Organometallic Compounds - pharmacology ; Other diseases. 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L</creatorcontrib><creatorcontrib>EWING, S. L</creatorcontrib><creatorcontrib>SPRINGFIELD, J</creatorcontrib><creatorcontrib>LEVITT, M. D</creatorcontrib><title>Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. 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| subjects | Animals Biological and medical sciences Bismuth - metabolism Bismuth - pharmacology Colitis - chemically induced Colitis - metabolism Colitis - pathology Colitis - prevention & control Colon - pathology Dextran Sulfate Feces - chemistry Gastroenterology. Liver. Pancreas. Abdomen Hydrogen Sulfide - antagonists & inhibitors Hydrogen Sulfide - metabolism Male Medical sciences Organometallic Compounds - metabolism Organometallic Compounds - pharmacology Other diseases. Semiology Rats Rats, Sprague-Dawley Reference Values Salicylates - metabolism Salicylates - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats |
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