Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression

Non-steroidal anti-inflammatory drugs (NSAIDs) induced gastric mucosal injury occurs through subsequent events following free radical production derived from activated neutrophils. In this study, we hypothesized that rebamipide, a novel anti-ulcer agent, exerts a protective effect on NSAID-induced g...

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Veröffentlicht in:	Digestive diseases and sciences 2005-10, Vol.50 Suppl 1, p.S84
Hauptverfasser:	Hiratsuka, Tetsuro, Futagami, Seiji, Shindo, Tomotaka, Hamamoto, Tatsuhiko, Ueki, Nobue, Suzuki, Kenji, Shinji, Yoko, Kusunoki, Masanori, Shinoki, Kei, Wada, Ken, Miyake, Kazumasa, Gudis, Katya, Tsukui, Taku, Sakamoto, Choitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Ulcer Agents - pharmacology Antioxidants - physiology Down-Regulation Female Gastric Mucosa - drug effects Gastric Mucosa - pathology Indomethacin - adverse effects Intercellular Adhesion Molecule-1 - biosynthesis Mice Mice, Inbred ICR Neutrophil Activation Quinolones - pharmacology Up-Regulation
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