Regional postprandial differences in pH within the stomach and gastroesophageal junction
Our objective was to determine regional differences in intragastric pH after different types of meals. Ten normal subjects underwent 27-hr esophagogastric pH monitoring using a four-probe pH catheter. Meals were a spicy lunch, a high-fat dinner, and a typical bland breakfast. The fatty dinner had th...
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| Veröffentlicht in: | Digestive diseases and sciences 2005-12, Vol.50 (12), p.2276-2285 |
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| creator | SIMONIAN, Hrair P VO, Lien DOMA, Siva FISHER, Robert S PARKMAN, Henry P |
| description | Our objective was to determine regional differences in intragastric pH after different types of meals. Ten normal subjects underwent 27-hr esophagogastric pH monitoring using a four-probe pH catheter. Meals were a spicy lunch, a high-fat dinner, and a typical bland breakfast. The fatty dinner had the highest postprandial buffering effect, elevating proximal and mid/distal gastric pH to 4.9 +/- 0.4 and 4.0 +/- 0.4, respectively, significantly (P < 0.05) higher compared to 4.2 +/- 0.3 and 3.0 +/- 0.4 for the spicy lunch and 3.0 +/- 0.3 and 2.5 +/- 0.8 for the breakfast. The buffering effect of the high-volume fatty meal to pH > 4 was also longer (150 min) compared to that of the spicy lunch (45 min) and the bland breakfast, which did not increase gastric pH to > 4 at any time. Proximal gastric acid pockets were seen between 15 and 90 min postprandially. These were located 3.4 +/- 0.8 cm below the proximal LES border, extending for a length of 2.3 +/- 0.8 cm, with a drop in mean pH from 4.7 +/- 0.4 to 1.5 +/- 0.9. Acid pockets were seen equally after the spicy lunch and fatty dinner but less frequently after the bland breakfast. We conclude that a high-volume fatty meal has the highest buffering effect on gastric pH compared to a spicy lunch or a bland breakfast. Buffering effects of meals are significantly higher in the proximal than in the mid/distal stomach. Despite the intragastric buffering effect of meals, focal areas of acidity were observed in the region of the cardia-gastroesophageal junction during the postprandial period. |
| doi_str_mv | 10.1007/s10620-005-3048-0 |
| format | Article |
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Ten normal subjects underwent 27-hr esophagogastric pH monitoring using a four-probe pH catheter. Meals were a spicy lunch, a high-fat dinner, and a typical bland breakfast. The fatty dinner had the highest postprandial buffering effect, elevating proximal and mid/distal gastric pH to 4.9 +/- 0.4 and 4.0 +/- 0.4, respectively, significantly (P < 0.05) higher compared to 4.2 +/- 0.3 and 3.0 +/- 0.4 for the spicy lunch and 3.0 +/- 0.3 and 2.5 +/- 0.8 for the breakfast. The buffering effect of the high-volume fatty meal to pH > 4 was also longer (150 min) compared to that of the spicy lunch (45 min) and the bland breakfast, which did not increase gastric pH to > 4 at any time. Proximal gastric acid pockets were seen between 15 and 90 min postprandially. These were located 3.4 +/- 0.8 cm below the proximal LES border, extending for a length of 2.3 +/- 0.8 cm, with a drop in mean pH from 4.7 +/- 0.4 to 1.5 +/- 0.9. Acid pockets were seen equally after the spicy lunch and fatty dinner but less frequently after the bland breakfast. We conclude that a high-volume fatty meal has the highest buffering effect on gastric pH compared to a spicy lunch or a bland breakfast. Buffering effects of meals are significantly higher in the proximal than in the mid/distal stomach. Despite the intragastric buffering effect of meals, focal areas of acidity were observed in the region of the cardia-gastroesophageal junction during the postprandial period.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-005-3048-0</identifier><identifier>PMID: 16416175</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Biological and medical sciences ; Esophagogastric Junction - physiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastric Acid - metabolism ; Gastric Acidity Determination ; Gastroscopy ; Humans ; Hydrogen-Ion Concentration ; Male ; Postprandial Period - physiology ; Prospective Studies ; Reference Values ; Sensitivity and Specificity ; Stomach - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2005-12, Vol.50 (12), p.2276-2285</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer Science + Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-c73e07f9911db2355bffdc9d30508f8cc2dc746092cd5c1da6ef965577838af3</citedby><cites>FETCH-LOGICAL-c325t-c73e07f9911db2355bffdc9d30508f8cc2dc746092cd5c1da6ef965577838af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17396493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16416175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SIMONIAN, Hrair P</creatorcontrib><creatorcontrib>VO, Lien</creatorcontrib><creatorcontrib>DOMA, Siva</creatorcontrib><creatorcontrib>FISHER, Robert S</creatorcontrib><creatorcontrib>PARKMAN, Henry P</creatorcontrib><title>Regional postprandial differences in pH within the stomach and gastroesophageal junction</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Our objective was to determine regional differences in intragastric pH after different types of meals. Ten normal subjects underwent 27-hr esophagogastric pH monitoring using a four-probe pH catheter. Meals were a spicy lunch, a high-fat dinner, and a typical bland breakfast. The fatty dinner had the highest postprandial buffering effect, elevating proximal and mid/distal gastric pH to 4.9 +/- 0.4 and 4.0 +/- 0.4, respectively, significantly (P < 0.05) higher compared to 4.2 +/- 0.3 and 3.0 +/- 0.4 for the spicy lunch and 3.0 +/- 0.3 and 2.5 +/- 0.8 for the breakfast. The buffering effect of the high-volume fatty meal to pH > 4 was also longer (150 min) compared to that of the spicy lunch (45 min) and the bland breakfast, which did not increase gastric pH to > 4 at any time. Proximal gastric acid pockets were seen between 15 and 90 min postprandially. These were located 3.4 +/- 0.8 cm below the proximal LES border, extending for a length of 2.3 +/- 0.8 cm, with a drop in mean pH from 4.7 +/- 0.4 to 1.5 +/- 0.9. Acid pockets were seen equally after the spicy lunch and fatty dinner but less frequently after the bland breakfast. We conclude that a high-volume fatty meal has the highest buffering effect on gastric pH compared to a spicy lunch or a bland breakfast. Buffering effects of meals are significantly higher in the proximal than in the mid/distal stomach. Despite the intragastric buffering effect of meals, focal areas of acidity were observed in the region of the cardia-gastroesophageal junction during the postprandial period.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Esophagogastric Junction - physiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Acidity Determination</subject><subject>Gastroscopy</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Postprandial Period - physiology</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Stomach - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkE1Lw0AQhhdRbK3-AC8SBI_RmWx2N3uUolYoCNKDt2W7H21Km8TdBPHfu6UBTzMDz_vCPITcIjwigHiKCLyAHIDlFMoqhzMyRSZoXjBenZMpIE87Ip-Qqxh3ACAF8ksyQV4iR8Gm5OvTbeq20fusa2PfBd3YOh229t4F1xgXs7rJukX2U_fbtPVbl8W-PWizzRKbbXTsQ-ti2231xqXkbmhMnxqvyYXX--huxjkjq9eX1XyRLz_e3ufPy9zQgvW5EdSB8FIi2nVBGVt7b420FBhUvjKmsEaUHGRhLDNoNXdecsaEqGilPZ2R-1NtF9rvwcVe7dohpH-iKrCkhZQUE4QnyIQ2xuC86kJ90OFXIaijSXUyqZJJdTSpIGXuxuJhfXD2PzGqS8DDCOho9N4ndaaO_5ygkpeS0j9DMXxA</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>SIMONIAN, Hrair P</creator><creator>VO, Lien</creator><creator>DOMA, Siva</creator><creator>FISHER, Robert S</creator><creator>PARKMAN, Henry P</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20051201</creationdate><title>Regional postprandial differences in pH within the stomach and gastroesophageal junction</title><author>SIMONIAN, Hrair P ; VO, Lien ; DOMA, Siva ; FISHER, Robert S ; PARKMAN, Henry P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-c73e07f9911db2355bffdc9d30508f8cc2dc746092cd5c1da6ef965577838af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Esophagogastric Junction - physiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Acidity Determination</topic><topic>Gastroscopy</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Postprandial Period - physiology</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Stomach - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SIMONIAN, Hrair P</creatorcontrib><creatorcontrib>VO, Lien</creatorcontrib><creatorcontrib>DOMA, Siva</creatorcontrib><creatorcontrib>FISHER, Robert S</creatorcontrib><creatorcontrib>PARKMAN, Henry P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SIMONIAN, Hrair P</au><au>VO, Lien</au><au>DOMA, Siva</au><au>FISHER, Robert S</au><au>PARKMAN, Henry P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional postprandial differences in pH within the stomach and gastroesophageal junction</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>50</volume><issue>12</issue><spage>2276</spage><epage>2285</epage><pages>2276-2285</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Our objective was to determine regional differences in intragastric pH after different types of meals. Ten normal subjects underwent 27-hr esophagogastric pH monitoring using a four-probe pH catheter. Meals were a spicy lunch, a high-fat dinner, and a typical bland breakfast. The fatty dinner had the highest postprandial buffering effect, elevating proximal and mid/distal gastric pH to 4.9 +/- 0.4 and 4.0 +/- 0.4, respectively, significantly (P < 0.05) higher compared to 4.2 +/- 0.3 and 3.0 +/- 0.4 for the spicy lunch and 3.0 +/- 0.3 and 2.5 +/- 0.8 for the breakfast. The buffering effect of the high-volume fatty meal to pH > 4 was also longer (150 min) compared to that of the spicy lunch (45 min) and the bland breakfast, which did not increase gastric pH to > 4 at any time. Proximal gastric acid pockets were seen between 15 and 90 min postprandially. These were located 3.4 +/- 0.8 cm below the proximal LES border, extending for a length of 2.3 +/- 0.8 cm, with a drop in mean pH from 4.7 +/- 0.4 to 1.5 +/- 0.9. Acid pockets were seen equally after the spicy lunch and fatty dinner but less frequently after the bland breakfast. We conclude that a high-volume fatty meal has the highest buffering effect on gastric pH compared to a spicy lunch or a bland breakfast. Buffering effects of meals are significantly higher in the proximal than in the mid/distal stomach. Despite the intragastric buffering effect of meals, focal areas of acidity were observed in the region of the cardia-gastroesophageal junction during the postprandial period.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>16416175</pmid><doi>10.1007/s10620-005-3048-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 2005-12, Vol.50 (12), p.2276-2285 |
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| subjects | Adult Biological and medical sciences Esophagogastric Junction - physiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastric Acid - metabolism Gastric Acidity Determination Gastroscopy Humans Hydrogen-Ion Concentration Male Postprandial Period - physiology Prospective Studies Reference Values Sensitivity and Specificity Stomach - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Regional postprandial differences in pH within the stomach and gastroesophageal junction |
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