The efficacy and limitations of sirolimus conversion in liver transplant patients who develop renal dysfunction on calcineurin inhibitors

This study evaluates sirolimus in preserving renal function in 28 patients who developed renal insufficiency after liver transplantation. Patients with a creatinine level higher than 1.8 mg/ml were eligible for conversion. Of the 28 patients, 7 (25%) did not tolerate sirolimus, 6 (21%) progressed to...

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Veröffentlicht in:	Digestive diseases and sciences 2004-06, Vol.49 (6), p.1029-1035
Hauptverfasser:	LAM, Patrick, YOSHIDA, Atsushi, BROWN, Kimberly, ABOULJOUD, Marwan, BAJJOKA, Iman, DAGHER, Fadi, MOONKA, Dilip K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcineurin - adverse effects Calcineurin Inhibitors Creatinine - blood Drug toxicity and drugs side effects treatment Feeding. Feeding behavior Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Liver Transplantation - adverse effects Male Medical sciences Metabolic diseases Middle Aged Pharmacology. Drug treatments Renal Insufficiency - etiology Renal Insufficiency - prevention & control Sirolimus - adverse effects Sirolimus - therapeutic use Time Factors Toxicity: urogenital system Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems
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