Acid-induced mesenteric hyperemia in rats: Role of CGRP, substance P, prostaglandin, adenosine, and histamine
Intraduodenal acidification produces a mesenteric hyperemia that is mediated in part by mucosal capsaicin-sensitive afferent nerves and the bradykinin B2 receptor in anesthetized rats. We hypothesized that novel mechanisms mediated by substance P, adenosine, and histamine1 receptors are involved. Co...
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| Veröffentlicht in: | Digestive diseases and sciences 2003-03, Vol.48 (3), p.523-532 |
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| creator | LEUNG, Felix W IWATA, Fumihiro SENO, Kyoji LEUNG, Joseph W. C |
| description | Intraduodenal acidification produces a mesenteric hyperemia that is mediated in part by mucosal capsaicin-sensitive afferent nerves and the bradykinin B2 receptor in anesthetized rats. We hypothesized that novel mechanisms mediated by substance P, adenosine, and histamine1 receptors are involved. Confirmation of a role for calcitonin gene-related peptide (CGRP) but not endogenous prostaglandin was also sought. In study 1, vehicle or antagonists (CGRP(8-37), CP 96345) was administered intravenously. Capsaicin or acid was administered intraduodenally, followed by intravenous CGRP or substance P. In study 2, pretreatments included indomethacin, 8-phenyltheophylline, pyrilamine, or the respective vehicles. Acid was then administered intraduodenally. In both studies, superior mesenteric artery blood flow was monitored. In study 1, the antagonists significantly attenuated capsaicin- and acid-induced mesenteric hyperemia. In study 2, the pretreatments did not alter acid-induced hyperemia. The data confirmed the role of CGRP and indicated for the first time an involvement for substance P in acid-induced mesenteric hyperemia. |
| doi_str_mv | 10.1023/A:1022536700151 |
| format | Article |
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C</creator><creatorcontrib>LEUNG, Felix W ; IWATA, Fumihiro ; SENO, Kyoji ; LEUNG, Joseph W. C</creatorcontrib><description>Intraduodenal acidification produces a mesenteric hyperemia that is mediated in part by mucosal capsaicin-sensitive afferent nerves and the bradykinin B2 receptor in anesthetized rats. We hypothesized that novel mechanisms mediated by substance P, adenosine, and histamine1 receptors are involved. Confirmation of a role for calcitonin gene-related peptide (CGRP) but not endogenous prostaglandin was also sought. In study 1, vehicle or antagonists (CGRP(8-37), CP 96345) was administered intravenously. Capsaicin or acid was administered intraduodenally, followed by intravenous CGRP or substance P. In study 2, pretreatments included indomethacin, 8-phenyltheophylline, pyrilamine, or the respective vehicles. Acid was then administered intraduodenally. In both studies, superior mesenteric artery blood flow was monitored. In study 1, the antagonists significantly attenuated capsaicin- and acid-induced mesenteric hyperemia. In study 2, the pretreatments did not alter acid-induced hyperemia. The data confirmed the role of CGRP and indicated for the first time an involvement for substance P in acid-induced mesenteric hyperemia.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1022536700151</identifier><identifier>PMID: 12757165</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adenosine - physiology ; Animals ; Biological and medical sciences ; Blood Flow Velocity ; Blood Pressure ; Calcitonin Gene-Related Peptide - pharmacology ; Calcitonin Gene-Related Peptide - physiology ; Capsaicin - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hydrochloric Acid - pharmacology ; Hyperemia - chemically induced ; Hyperemia - physiopathology ; Intestinal Mucosa - physiology ; Intestine. Mesentery ; Laser-Doppler Flowmetry ; Male ; Mesenteric Artery, Superior - physiopathology ; Mesentery - blood supply ; Nerve Tissue Proteins - physiology ; Prostaglandins - physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Histamine H1 - physiology ; Regional Blood Flow - physiology ; Substance P - pharmacology ; Substance P - physiology ; Vasodilator Agents - pharmacology ; Vertebrates: digestive system</subject><ispartof>Digestive diseases and sciences, 2003-03, Vol.48 (3), p.523-532</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Mar 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-d08600bd82ec0ff699f6cbe028c24538f6930dbcdf4ae5517274cb0362f18b933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14695335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12757165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEUNG, Felix W</creatorcontrib><creatorcontrib>IWATA, Fumihiro</creatorcontrib><creatorcontrib>SENO, Kyoji</creatorcontrib><creatorcontrib>LEUNG, Joseph W. C</creatorcontrib><title>Acid-induced mesenteric hyperemia in rats: Role of CGRP, substance P, prostaglandin, adenosine, and histamine</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Intraduodenal acidification produces a mesenteric hyperemia that is mediated in part by mucosal capsaicin-sensitive afferent nerves and the bradykinin B2 receptor in anesthetized rats. We hypothesized that novel mechanisms mediated by substance P, adenosine, and histamine1 receptors are involved. Confirmation of a role for calcitonin gene-related peptide (CGRP) but not endogenous prostaglandin was also sought. In study 1, vehicle or antagonists (CGRP(8-37), CP 96345) was administered intravenously. Capsaicin or acid was administered intraduodenally, followed by intravenous CGRP or substance P. In study 2, pretreatments included indomethacin, 8-phenyltheophylline, pyrilamine, or the respective vehicles. Acid was then administered intraduodenally. In both studies, superior mesenteric artery blood flow was monitored. In study 1, the antagonists significantly attenuated capsaicin- and acid-induced mesenteric hyperemia. In study 2, the pretreatments did not alter acid-induced hyperemia. The data confirmed the role of CGRP and indicated for the first time an involvement for substance P in acid-induced mesenteric hyperemia.</description><subject>Adenosine - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>Calcitonin Gene-Related Peptide - pharmacology</subject><subject>Calcitonin Gene-Related Peptide - physiology</subject><subject>Capsaicin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrochloric Acid - pharmacology</subject><subject>Hyperemia - chemically induced</subject><subject>Hyperemia - physiopathology</subject><subject>Intestinal Mucosa - physiology</subject><subject>Intestine. Mesentery</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Mesenteric Artery, Superior - physiopathology</subject><subject>Mesentery - blood supply</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Prostaglandins - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Histamine H1 - physiology</subject><subject>Regional Blood Flow - physiology</subject><subject>Substance P - pharmacology</subject><subject>Substance P - physiology</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vertebrates: digestive system</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkMtLAzEQxoMotlbP3iQI3rqaxya721spvqCgFD0v2WRiU3azNdk99L83YMXTfN_Mj3khdE3JPSWMPywXKTDBZUEIFfQETakoeMaELE_RlFCZNKVygi5i3BFCqoLKczShrBBJiSnqltqZzHkzajC4gwh-gOA03h72EKBzCjuPgxriAm_6FnBv8ep58z7HcWzioLwGnMw-9Ml8tcob5-dYGfB9dB6S9AZvXSp2yV6iM6vaCFfHOEOfT48fq5ds_fb8ulquM825HDJDSklIY0oGmlgrq8pK3QBhpWa54GXKcGIabWyuQAhasCLXDeGSWVo2FeczdPvbN-31PUIc6l0_Bp9G1ozmPL1H0gTdHKGx6cDU--A6FQ7133MScHcEVNSqtSFd6-I_l8tKcC74D91Xckw</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>LEUNG, Felix W</creator><creator>IWATA, Fumihiro</creator><creator>SENO, Kyoji</creator><creator>LEUNG, Joseph W. 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C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-d08600bd82ec0ff699f6cbe028c24538f6930dbcdf4ae5517274cb0362f18b933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenosine - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>Calcitonin Gene-Related Peptide - pharmacology</topic><topic>Calcitonin Gene-Related Peptide - physiology</topic><topic>Capsaicin - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrochloric Acid - pharmacology</topic><topic>Hyperemia - chemically induced</topic><topic>Hyperemia - physiopathology</topic><topic>Intestinal Mucosa - physiology</topic><topic>Intestine. Mesentery</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Mesenteric Artery, Superior - physiopathology</topic><topic>Mesentery - blood supply</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Prostaglandins - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Histamine H1 - physiology</topic><topic>Regional Blood Flow - physiology</topic><topic>Substance P - pharmacology</topic><topic>Substance P - physiology</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEUNG, Felix W</creatorcontrib><creatorcontrib>IWATA, Fumihiro</creatorcontrib><creatorcontrib>SENO, Kyoji</creatorcontrib><creatorcontrib>LEUNG, Joseph W. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acid-induced mesenteric hyperemia in rats: Role of CGRP, substance P, prostaglandin, adenosine, and histamine</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>48</volume><issue>3</issue><spage>523</spage><epage>532</epage><pages>523-532</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Intraduodenal acidification produces a mesenteric hyperemia that is mediated in part by mucosal capsaicin-sensitive afferent nerves and the bradykinin B2 receptor in anesthetized rats. We hypothesized that novel mechanisms mediated by substance P, adenosine, and histamine1 receptors are involved. Confirmation of a role for calcitonin gene-related peptide (CGRP) but not endogenous prostaglandin was also sought. In study 1, vehicle or antagonists (CGRP(8-37), CP 96345) was administered intravenously. Capsaicin or acid was administered intraduodenally, followed by intravenous CGRP or substance P. In study 2, pretreatments included indomethacin, 8-phenyltheophylline, pyrilamine, or the respective vehicles. Acid was then administered intraduodenally. In both studies, superior mesenteric artery blood flow was monitored. In study 1, the antagonists significantly attenuated capsaicin- and acid-induced mesenteric hyperemia. In study 2, the pretreatments did not alter acid-induced hyperemia. The data confirmed the role of CGRP and indicated for the first time an involvement for substance P in acid-induced mesenteric hyperemia.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>12757165</pmid><doi>10.1023/A:1022536700151</doi><tpages>10</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 2003-03, Vol.48 (3), p.523-532 |
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| subjects | Adenosine - physiology Animals Biological and medical sciences Blood Flow Velocity Blood Pressure Calcitonin Gene-Related Peptide - pharmacology Calcitonin Gene-Related Peptide - physiology Capsaicin - pharmacology Fundamental and applied biological sciences. Psychology Hydrochloric Acid - pharmacology Hyperemia - chemically induced Hyperemia - physiopathology Intestinal Mucosa - physiology Intestine. Mesentery Laser-Doppler Flowmetry Male Mesenteric Artery, Superior - physiopathology Mesentery - blood supply Nerve Tissue Proteins - physiology Prostaglandins - physiology Rats Rats, Sprague-Dawley Receptors, Histamine H1 - physiology Regional Blood Flow - physiology Substance P - pharmacology Substance P - physiology Vasodilator Agents - pharmacology Vertebrates: digestive system |
| title | Acid-induced mesenteric hyperemia in rats: Role of CGRP, substance P, prostaglandin, adenosine, and histamine |
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