Resistance to apoptosis is increased during metastatic dissemination of colon cancer

Apoptosis dysfunction in metastases has been suggested to participate in their poor response to conventional anticancer treatments. To address this question, we have analyzed the sensitivity to cell death induced by non-steroid anti-inflammatory drug, Sulindac, the most common drug used in colon can...

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Veröffentlicht in:	Clinical & experimental metastasis 2002-01, Vol.19 (2), p.175
Hauptverfasser:	Oliver, L, Cordel, S, Barbieux, I, LeCabellec, M T, Meflah, K, Grégoire, M, Vallette, F M
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin A5 - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antimetabolites, Antineoplastic - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein bcl-X Protein Blotting, Western Butyrates - pharmacology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Drug Resistance, Neoplasm Fluorouracil - pharmacology HT29 Cells - drug effects HT29 Cells - metabolism Humans Liver Neoplasms - metabolism Liver Neoplasms - secondary Lymphatic Metastasis - pathology Phenotype Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Sulindac - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Suppressor Protein p53 - metabolism
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