Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial
PURPOSE:The maximum resting pressure in the anal canal is greatly raised after hemorrhoidectomy. This increase is likely to be the cause of postoperative pain, which is still the most troublesome early problem after hemorrhoidectomy. This study was designed to compare, after hemorrhoidectomy, the ef...
Gespeichert in:
| Veröffentlicht in: | Diseases of the colon & rectum 2006-11, Vol.49 (11), p.1741-1748 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1748 |
|---|---|
| container_issue | 11 |
| container_start_page | 1741 |
| container_title | Diseases of the colon & rectum |
| container_volume | 49 |
| creator | Patti, Rosalia Luigi, Almasio Piero Matteo, Arcara Sergio, Sammartano Pietro, Romano Calogero, Fede Gaetano, Di Vita |
| description | PURPOSE:The maximum resting pressure in the anal canal is greatly raised after hemorrhoidectomy. This increase is likely to be the cause of postoperative pain, which is still the most troublesome early problem after hemorrhoidectomy. This study was designed to compare, after hemorrhoidectomy, the effects of intrasphincter injection of botulinum toxin vs. application of glyceryl trinitrate ointment in improving wound healing and reducing postoperative pain at rest or during defecation.
METHODS:
RESULTS:Five days after hemorrhoidectomy, maximum resting pressure was significantly reduced compared with baseline values in both groups (85 ± 15 vs. 68 ± 11 mmHg for the group treated with botulinum toxin, 87 ± 11 vs. 78 ± 11 mmHg for the group treated with glyceryl trinitrate ointment). Overall analysis of postoperative pain at rest showed a significant reduction in the botulinum toxin group vs. glyceryl trinitrate group, whereas pain during defecation and time of healing were similar. Adverse effects, such as headaches, were observed only in the glyceryl trinitrate group. Forty days after hemorrhoidectomy in the glyceryl trinitrate group, maximum resting pressure values were similar to preoperative ones, whereas the values were still reduced in the botulinum toxin group.
CONCLUSIONS: |
| doi_str_mv | 10.1007/s10350-006-0677-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_214055292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1175557581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4920-b726c1f5f0303e50e1d04d59a5f46532f4333d688e49029f478bc07c3daa5fa93</originalsourceid><addsrcrecordid>eNpFkc1uEzEUhS0EoqHwAGyQhcRyyvXfeMyujWiLVKkVSteWM-NpXDx2sD2UdM974yiRuvK1_Z1zpHMR-kjgjADIr5kAE9AAtA20UjbwCi2IYPWFie41WgAQ2jAJ7Ql6l_NjvQIF-RadkFYpULJdoH8XsczehXnCq_jXBfwnn9Vp63rj8ZXf9TbtPF4lF1xJplh860KZbCh4jAnfmapYxlBS9LiOd6a4-pfxfRhseoguPOBrO8WUNtENti9x2n3D5_inCUOc3LMd9tbGv0dvRuOz_XA8T9H95ffV8rq5ub36sTy_aXquKDRrSduejGIEBswKsGQAPghlxMhbwejIGWND23WWK6Bq5LJb9yB7NpiKGMVO0eeD7zbF37PNRT_GOYUaqSnhIARVtELkAPUp5pzsqLfJTSbtNAG9710fete1d73vXUPVfDoaz-vJDi-KY9EV-HIETK7VjsmE3uUXrmNQ19NVjh-4p-iLTfmXn59s0htrfNnURADGBWtozeaKkP3y61bZfxLUmx4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214055292</pqid></control><display><type>article</type><title>Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Journals@Ovid Complete</source><creator>Patti, Rosalia ; Luigi, Almasio Piero ; Matteo, Arcara ; Sergio, Sammartano ; Pietro, Romano ; Calogero, Fede ; Gaetano, Di Vita</creator><creatorcontrib>Patti, Rosalia ; Luigi, Almasio Piero ; Matteo, Arcara ; Sergio, Sammartano ; Pietro, Romano ; Calogero, Fede ; Gaetano, Di Vita</creatorcontrib><description>PURPOSE:The maximum resting pressure in the anal canal is greatly raised after hemorrhoidectomy. This increase is likely to be the cause of postoperative pain, which is still the most troublesome early problem after hemorrhoidectomy. This study was designed to compare, after hemorrhoidectomy, the effects of intrasphincter injection of botulinum toxin vs. application of glyceryl trinitrate ointment in improving wound healing and reducing postoperative pain at rest or during defecation.
METHODS:
RESULTS:Five days after hemorrhoidectomy, maximum resting pressure was significantly reduced compared with baseline values in both groups (85 ± 15 vs. 68 ± 11 mmHg for the group treated with botulinum toxin, 87 ± 11 vs. 78 ± 11 mmHg for the group treated with glyceryl trinitrate ointment). Overall analysis of postoperative pain at rest showed a significant reduction in the botulinum toxin group vs. glyceryl trinitrate group, whereas pain during defecation and time of healing were similar. Adverse effects, such as headaches, were observed only in the glyceryl trinitrate group. Forty days after hemorrhoidectomy in the glyceryl trinitrate group, maximum resting pressure values were similar to preoperative ones, whereas the values were still reduced in the botulinum toxin group.
CONCLUSIONS:</description><identifier>ISSN: 0012-3706</identifier><identifier>EISSN: 1530-0358</identifier><identifier>DOI: 10.1007/s10350-006-0677-0</identifier><identifier>PMID: 16990976</identifier><identifier>CODEN: DICRAG</identifier><language>eng</language><publisher>Secaucus, NJ: The ASCRS</publisher><subject>Adult ; Biological and medical sciences ; Botulinum Toxins, Type A - therapeutic use ; Defecation ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hemorrhoids - surgery ; Humans ; Injections ; Male ; Manometry ; Medical sciences ; Neuromuscular Agents - therapeutic use ; Nitroglycerin - therapeutic use ; Ointments ; Other diseases. Semiology ; Pain Measurement ; Pain, Postoperative - prevention & control ; Rest ; Stomach, duodenum, intestine, rectum, anus ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Treatment Outcome</subject><ispartof>Diseases of the colon & rectum, 2006-11, Vol.49 (11), p.1741-1748</ispartof><rights>The ASCRS 2006</rights><rights>2007 INIST-CNRS</rights><rights>The American Society of Colon and Rectal Surgeons 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4920-b726c1f5f0303e50e1d04d59a5f46532f4333d688e49029f478bc07c3daa5fa93</citedby><cites>FETCH-LOGICAL-c4920-b726c1f5f0303e50e1d04d59a5f46532f4333d688e49029f478bc07c3daa5fa93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18300018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16990976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patti, Rosalia</creatorcontrib><creatorcontrib>Luigi, Almasio Piero</creatorcontrib><creatorcontrib>Matteo, Arcara</creatorcontrib><creatorcontrib>Sergio, Sammartano</creatorcontrib><creatorcontrib>Pietro, Romano</creatorcontrib><creatorcontrib>Calogero, Fede</creatorcontrib><creatorcontrib>Gaetano, Di Vita</creatorcontrib><title>Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial</title><title>Diseases of the colon & rectum</title><addtitle>Dis Colon Rectum</addtitle><description>PURPOSE:The maximum resting pressure in the anal canal is greatly raised after hemorrhoidectomy. This increase is likely to be the cause of postoperative pain, which is still the most troublesome early problem after hemorrhoidectomy. This study was designed to compare, after hemorrhoidectomy, the effects of intrasphincter injection of botulinum toxin vs. application of glyceryl trinitrate ointment in improving wound healing and reducing postoperative pain at rest or during defecation.
METHODS:
RESULTS:Five days after hemorrhoidectomy, maximum resting pressure was significantly reduced compared with baseline values in both groups (85 ± 15 vs. 68 ± 11 mmHg for the group treated with botulinum toxin, 87 ± 11 vs. 78 ± 11 mmHg for the group treated with glyceryl trinitrate ointment). Overall analysis of postoperative pain at rest showed a significant reduction in the botulinum toxin group vs. glyceryl trinitrate group, whereas pain during defecation and time of healing were similar. Adverse effects, such as headaches, were observed only in the glyceryl trinitrate group. Forty days after hemorrhoidectomy in the glyceryl trinitrate group, maximum resting pressure values were similar to preoperative ones, whereas the values were still reduced in the botulinum toxin group.
CONCLUSIONS:</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Botulinum Toxins, Type A - therapeutic use</subject><subject>Defecation</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hemorrhoids - surgery</subject><subject>Humans</subject><subject>Injections</subject><subject>Male</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Neuromuscular Agents - therapeutic use</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Ointments</subject><subject>Other diseases. Semiology</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Rest</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Treatment Outcome</subject><issn>0012-3706</issn><issn>1530-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1uEzEUhS0EoqHwAGyQhcRyyvXfeMyujWiLVKkVSteWM-NpXDx2sD2UdM974yiRuvK1_Z1zpHMR-kjgjADIr5kAE9AAtA20UjbwCi2IYPWFie41WgAQ2jAJ7Ql6l_NjvQIF-RadkFYpULJdoH8XsczehXnCq_jXBfwnn9Vp63rj8ZXf9TbtPF4lF1xJplh860KZbCh4jAnfmapYxlBS9LiOd6a4-pfxfRhseoguPOBrO8WUNtENti9x2n3D5_inCUOc3LMd9tbGv0dvRuOz_XA8T9H95ffV8rq5ub36sTy_aXquKDRrSduejGIEBswKsGQAPghlxMhbwejIGWND23WWK6Bq5LJb9yB7NpiKGMVO0eeD7zbF37PNRT_GOYUaqSnhIARVtELkAPUp5pzsqLfJTSbtNAG9710fete1d73vXUPVfDoaz-vJDi-KY9EV-HIETK7VjsmE3uUXrmNQ19NVjh-4p-iLTfmXn59s0htrfNnURADGBWtozeaKkP3y61bZfxLUmx4</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Patti, Rosalia</creator><creator>Luigi, Almasio Piero</creator><creator>Matteo, Arcara</creator><creator>Sergio, Sammartano</creator><creator>Pietro, Romano</creator><creator>Calogero, Fede</creator><creator>Gaetano, Di Vita</creator><general>The ASCRS</general><general>Springer</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>200611</creationdate><title>Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial</title><author>Patti, Rosalia ; Luigi, Almasio Piero ; Matteo, Arcara ; Sergio, Sammartano ; Pietro, Romano ; Calogero, Fede ; Gaetano, Di Vita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4920-b726c1f5f0303e50e1d04d59a5f46532f4333d688e49029f478bc07c3daa5fa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>Defecation</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hemorrhoids - surgery</topic><topic>Humans</topic><topic>Injections</topic><topic>Male</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>Nitroglycerin - therapeutic use</topic><topic>Ointments</topic><topic>Other diseases. Semiology</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Rest</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patti, Rosalia</creatorcontrib><creatorcontrib>Luigi, Almasio Piero</creatorcontrib><creatorcontrib>Matteo, Arcara</creatorcontrib><creatorcontrib>Sergio, Sammartano</creatorcontrib><creatorcontrib>Pietro, Romano</creatorcontrib><creatorcontrib>Calogero, Fede</creatorcontrib><creatorcontrib>Gaetano, Di Vita</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Diseases of the colon & rectum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patti, Rosalia</au><au>Luigi, Almasio Piero</au><au>Matteo, Arcara</au><au>Sergio, Sammartano</au><au>Pietro, Romano</au><au>Calogero, Fede</au><au>Gaetano, Di Vita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial</atitle><jtitle>Diseases of the colon & rectum</jtitle><addtitle>Dis Colon Rectum</addtitle><date>2006-11</date><risdate>2006</risdate><volume>49</volume><issue>11</issue><spage>1741</spage><epage>1748</epage><pages>1741-1748</pages><issn>0012-3706</issn><eissn>1530-0358</eissn><coden>DICRAG</coden><abstract>PURPOSE:The maximum resting pressure in the anal canal is greatly raised after hemorrhoidectomy. This increase is likely to be the cause of postoperative pain, which is still the most troublesome early problem after hemorrhoidectomy. This study was designed to compare, after hemorrhoidectomy, the effects of intrasphincter injection of botulinum toxin vs. application of glyceryl trinitrate ointment in improving wound healing and reducing postoperative pain at rest or during defecation.
METHODS:
RESULTS:Five days after hemorrhoidectomy, maximum resting pressure was significantly reduced compared with baseline values in both groups (85 ± 15 vs. 68 ± 11 mmHg for the group treated with botulinum toxin, 87 ± 11 vs. 78 ± 11 mmHg for the group treated with glyceryl trinitrate ointment). Overall analysis of postoperative pain at rest showed a significant reduction in the botulinum toxin group vs. glyceryl trinitrate group, whereas pain during defecation and time of healing were similar. Adverse effects, such as headaches, were observed only in the glyceryl trinitrate group. Forty days after hemorrhoidectomy in the glyceryl trinitrate group, maximum resting pressure values were similar to preoperative ones, whereas the values were still reduced in the botulinum toxin group.
CONCLUSIONS:</abstract><cop>Secaucus, NJ</cop><pub>The ASCRS</pub><pmid>16990976</pmid><doi>10.1007/s10350-006-0677-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3706 |
| ispartof | Diseases of the colon & rectum, 2006-11, Vol.49 (11), p.1741-1748 |
| issn | 0012-3706 1530-0358 |
| language | eng |
| recordid | cdi_proquest_journals_214055292 |
| source | MEDLINE; SpringerLink Journals; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Botulinum Toxins, Type A - therapeutic use Defecation Female Gastroenterology. Liver. Pancreas. Abdomen Hemorrhoids - surgery Humans Injections Male Manometry Medical sciences Neuromuscular Agents - therapeutic use Nitroglycerin - therapeutic use Ointments Other diseases. Semiology Pain Measurement Pain, Postoperative - prevention & control Rest Stomach, duodenum, intestine, rectum, anus Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Treatment Outcome |
| title | Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A56%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Botulinum%20Toxin%20vs.%20Topical%20Glyceryl%20Trinitrate%20Ointment%20for%20Pain%20Control%20in%20Patients%20Undergoing%20Hemorrhoidectomy:%20A%20Randomized%20Trial&rft.jtitle=Diseases%20of%20the%20colon%20&%20rectum&rft.au=Patti,%20Rosalia&rft.date=2006-11&rft.volume=49&rft.issue=11&rft.spage=1741&rft.epage=1748&rft.pages=1741-1748&rft.issn=0012-3706&rft.eissn=1530-0358&rft.coden=DICRAG&rft_id=info:doi/10.1007/s10350-006-0677-0&rft_dat=%3Cproquest_cross%3E1175557581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214055292&rft_id=info:pmid/16990976&rfr_iscdi=true |