177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: synthesis and assessment of the ability to target the prostate specific membrane antigen
SPECT/CT images have proved the capability of 99m Tc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepa...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2018, Vol.318 (3), p.2059-2066 |
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| creator | Hernández-Jiménez, Tania Ferro-Flores, Guillermina Ocampo-García, Blanca Morales-Avila, Enrique Escudero-Castellanos, Alondra Azorín-Vega, Erika Santos-Cuevas, Clara Luna-Gutiérrez, Myrna Jiménez-Mancilla, Nallely Medina, Luis Alberto Ramirez, Flor de Maria Pedraza-López, Martha |
| description | SPECT/CT images have proved the capability of
99m
Tc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepare
177
Lu-DOTA-HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu (
177
Lu-iPSMA) and evaluate the in vitro and in vivo radiotracer ability to target the PSMA protein overexpressed in prostate cancer cells (LNCaP).
177
Lu-iPSMA, obtained with radiochemical purities of 99%, showed specific in vitro and in vivo recognition for PSMA in prostate cancer cells and high LNCaP-tumor uptake (11 ± 2% ID/g at 24 h). The results obtained warrant further studies to evaluate the therapeutic efficacy of
177
Lu-iPSMA. |
| doi_str_mv | 10.1007/s10967-018-6239-9 |
| format | Article |
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99m
Tc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepare
177
Lu-DOTA-HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu (
177
Lu-iPSMA) and evaluate the in vitro and in vivo radiotracer ability to target the PSMA protein overexpressed in prostate cancer cells (LNCaP).
177
Lu-iPSMA, obtained with radiochemical purities of 99%, showed specific in vitro and in vivo recognition for PSMA in prostate cancer cells and high LNCaP-tumor uptake (11 ± 2% ID/g at 24 h). The results obtained warrant further studies to evaluate the therapeutic efficacy of
177
Lu-iPSMA.</description><identifier>ISSN: 0236-5731</identifier><identifier>EISSN: 1588-2780</identifier><identifier>DOI: 10.1007/s10967-018-6239-9</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Chemistry ; Chemistry and Materials Science ; Computed tomography ; Diagnostic Radiology ; Diagnostic systems ; Hadrons ; Heavy Ions ; Image detection ; Inorganic Chemistry ; Lutetium isotopes ; Nuclear Chemistry ; Nuclear Physics ; Physical Chemistry ; Prostate cancer ; Proteins ; Radioactive tracers ; Radiochemistry ; Radioisotopes ; Tumors</subject><ispartof>Journal of radioanalytical and nuclear chemistry, 2018, Vol.318 (3), p.2059-2066</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1619-404182bb7f0261ef0c56b34582e9c35f35aa61b319db7d3168fd4035b5f9bb753</citedby><cites>FETCH-LOGICAL-c1619-404182bb7f0261ef0c56b34582e9c35f35aa61b319db7d3168fd4035b5f9bb753</cites><orcidid>0000-0003-0296-7605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10967-018-6239-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10967-018-6239-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Hernández-Jiménez, Tania</creatorcontrib><creatorcontrib>Ferro-Flores, Guillermina</creatorcontrib><creatorcontrib>Ocampo-García, Blanca</creatorcontrib><creatorcontrib>Morales-Avila, Enrique</creatorcontrib><creatorcontrib>Escudero-Castellanos, Alondra</creatorcontrib><creatorcontrib>Azorín-Vega, Erika</creatorcontrib><creatorcontrib>Santos-Cuevas, Clara</creatorcontrib><creatorcontrib>Luna-Gutiérrez, Myrna</creatorcontrib><creatorcontrib>Jiménez-Mancilla, Nallely</creatorcontrib><creatorcontrib>Medina, Luis Alberto</creatorcontrib><creatorcontrib>Ramirez, Flor de Maria</creatorcontrib><creatorcontrib>Pedraza-López, Martha</creatorcontrib><title>177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: synthesis and assessment of the ability to target the prostate specific membrane antigen</title><title>Journal of radioanalytical and nuclear chemistry</title><addtitle>J Radioanal Nucl Chem</addtitle><description>SPECT/CT images have proved the capability of
99m
Tc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepare
177
Lu-DOTA-HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu (
177
Lu-iPSMA) and evaluate the in vitro and in vivo radiotracer ability to target the PSMA protein overexpressed in prostate cancer cells (LNCaP).
177
Lu-iPSMA, obtained with radiochemical purities of 99%, showed specific in vitro and in vivo recognition for PSMA in prostate cancer cells and high LNCaP-tumor uptake (11 ± 2% ID/g at 24 h). The results obtained warrant further studies to evaluate the therapeutic efficacy of
177
Lu-iPSMA.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Computed tomography</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Image detection</subject><subject>Inorganic Chemistry</subject><subject>Lutetium isotopes</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Physical Chemistry</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Radioactive tracers</subject><subject>Radiochemistry</subject><subject>Radioisotopes</subject><subject>Tumors</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kDtPAzEQhC0EEiHwA-gs0UBh8J7PLzoUnlIETVJQWb6LHQ4ll-B1ikj8eAxBoqJaaXe-2dEQcgr8EjjXVwjcKs04GKYqYZndIwOQxrBKG75PBrwSikkt4JAcIb5zzq0xYkA-Qevxht2-TG7Y4-vz04iNt3j-7BcXbJqCZw-LzTXFbZ_fAnZIfT-jHjEgLkOf6SrScqC-6RZd3tK8otmnecg_23VaYfY5UFyHtotdS5dh2STfF6DP3Tz0x-Qg-gWGk985JNP7u8nokY1fHp5GN2PWggLLal6DqZpGR14pCJG3UjWilqYKthUyCum9gkaAnTV6JkCZOKu5kI2MtlBSDMnZzrdE-tgEzO59tUl9eekqqDkoDaCLCnaqtgTHFKJbp27p09YBd98lu13JrpTsvkt2tjDVjsGi7ech_Tn_D30B6ap-HQ</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Hernández-Jiménez, Tania</creator><creator>Ferro-Flores, Guillermina</creator><creator>Ocampo-García, Blanca</creator><creator>Morales-Avila, Enrique</creator><creator>Escudero-Castellanos, Alondra</creator><creator>Azorín-Vega, Erika</creator><creator>Santos-Cuevas, Clara</creator><creator>Luna-Gutiérrez, Myrna</creator><creator>Jiménez-Mancilla, Nallely</creator><creator>Medina, Luis Alberto</creator><creator>Ramirez, Flor de Maria</creator><creator>Pedraza-López, Martha</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-0296-7605</orcidid></search><sort><creationdate>2018</creationdate><title>177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: synthesis and assessment of the ability to target the prostate specific membrane antigen</title><author>Hernández-Jiménez, Tania ; Ferro-Flores, Guillermina ; Ocampo-García, Blanca ; Morales-Avila, Enrique ; Escudero-Castellanos, Alondra ; Azorín-Vega, Erika ; Santos-Cuevas, Clara ; Luna-Gutiérrez, Myrna ; Jiménez-Mancilla, Nallely ; Medina, Luis Alberto ; Ramirez, Flor de Maria ; Pedraza-López, Martha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1619-404182bb7f0261ef0c56b34582e9c35f35aa61b319db7d3168fd4035b5f9bb753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Computed tomography</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Image detection</topic><topic>Inorganic Chemistry</topic><topic>Lutetium isotopes</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Physical Chemistry</topic><topic>Prostate cancer</topic><topic>Proteins</topic><topic>Radioactive tracers</topic><topic>Radiochemistry</topic><topic>Radioisotopes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernández-Jiménez, Tania</creatorcontrib><creatorcontrib>Ferro-Flores, Guillermina</creatorcontrib><creatorcontrib>Ocampo-García, Blanca</creatorcontrib><creatorcontrib>Morales-Avila, Enrique</creatorcontrib><creatorcontrib>Escudero-Castellanos, Alondra</creatorcontrib><creatorcontrib>Azorín-Vega, Erika</creatorcontrib><creatorcontrib>Santos-Cuevas, Clara</creatorcontrib><creatorcontrib>Luna-Gutiérrez, Myrna</creatorcontrib><creatorcontrib>Jiménez-Mancilla, Nallely</creatorcontrib><creatorcontrib>Medina, Luis Alberto</creatorcontrib><creatorcontrib>Ramirez, Flor de Maria</creatorcontrib><creatorcontrib>Pedraza-López, Martha</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández-Jiménez, Tania</au><au>Ferro-Flores, Guillermina</au><au>Ocampo-García, Blanca</au><au>Morales-Avila, Enrique</au><au>Escudero-Castellanos, Alondra</au><au>Azorín-Vega, Erika</au><au>Santos-Cuevas, Clara</au><au>Luna-Gutiérrez, Myrna</au><au>Jiménez-Mancilla, Nallely</au><au>Medina, Luis Alberto</au><au>Ramirez, Flor de Maria</au><au>Pedraza-López, Martha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: synthesis and assessment of the ability to target the prostate specific membrane antigen</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2018</date><risdate>2018</risdate><volume>318</volume><issue>3</issue><spage>2059</spage><epage>2066</epage><pages>2059-2066</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>SPECT/CT images have proved the capability of
99m
Tc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepare
177
Lu-DOTA-HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu (
177
Lu-iPSMA) and evaluate the in vitro and in vivo radiotracer ability to target the PSMA protein overexpressed in prostate cancer cells (LNCaP).
177
Lu-iPSMA, obtained with radiochemical purities of 99%, showed specific in vitro and in vivo recognition for PSMA in prostate cancer cells and high LNCaP-tumor uptake (11 ± 2% ID/g at 24 h). The results obtained warrant further studies to evaluate the therapeutic efficacy of
177
Lu-iPSMA.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10967-018-6239-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0296-7605</orcidid></addata></record> |
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| subjects | Chemistry Chemistry and Materials Science Computed tomography Diagnostic Radiology Diagnostic systems Hadrons Heavy Ions Image detection Inorganic Chemistry Lutetium isotopes Nuclear Chemistry Nuclear Physics Physical Chemistry Prostate cancer Proteins Radioactive tracers Radiochemistry Radioisotopes Tumors |
| title | 177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: synthesis and assessment of the ability to target the prostate specific membrane antigen |
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