Processing of Pro-Brain Natriuretic Peptide Is Suppressed by O-Glycosylation in the Region Close to the Cleavage Site

Processing of the brain natriuretic peptide (BNP) precursor, proBNP, is a convertase-dependent reaction that produces 2 molecules--the active BNP hormone and the N-terminal part of proBNP (NT-proBNP). Although proBNP was first described more than 15 years ago, very little is known about the cellular...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2009-03, Vol.55 (3), p.489-498
Hauptverfasser:	Semenov, Alexander G, Postnikov, Alexander B, Tamm, Natalia N, Seferian, Karina R, Karpova, Natalia S, Bloshchitsyna, Marina N, Koshkina, Ekaterina V, Krasnoselsky, Mihail I, Serebryanaya, Daria V, Katrukha, Alexey G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Cell Line Cricetinae E coli Furin - metabolism Glycosylation Heart failure Humans Mice Mutagenesis Mutagenesis, Site-Directed Natriuretic Peptide, Brain - chemistry Natriuretic Peptide, Brain - genetics Natriuretic Peptide, Brain - immunology Natriuretic Peptide, Brain - metabolism Patients Protein Precursors - chemistry Protein Precursors - genetics Protein Precursors - immunology Protein Precursors - metabolism Studies
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