Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs
Purpose of Review Herpesviruses are large DNA viruses whose genomes contain a number of genes producing non-coding RNAs, such as small RNA and long non-coding RNA. In this review, the expression and function of Kaposi’s sarcoma-associated herpesvirus (KSHV) non-coding RNAs are discussed. Recent Find...
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| Veröffentlicht in: | Current clinical microbiology reports 2018-12, Vol.5 (4), p.211-218 |
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| creator | Katano, Harutaka |
| description | Purpose of Review
Herpesviruses are large DNA viruses whose genomes contain a number of genes producing non-coding RNAs, such as small RNA and long non-coding RNA. In this review, the expression and function of Kaposi’s sarcoma-associated herpesvirus (KSHV) non-coding RNAs are discussed.
Recent Findings
The KSHV genome contains at least 12 genes from which pre-microRNAs (miRNAs) are transcribed, and several genes producing long non-coding RNAs (lncRNAs). Polyadenylated nuclear RNA is a highly expressed viral lncRNA molecule in KSHV-infected cells and is necessary for KSHV replication. KSHV miRNAs are expressed predominantly during the latent phase of KSHV infection not only in cells but also in extracellular vesicles such as exosomes and virions. Identification of viral miRNA targets has revealed that KSHV miRNAs have various functions relating to oncogenesis, anti-apoptosis, angiogenesis, and migration of KSHV-infected cells. Some KSHV miRNAs regulate KSHV replication to maintain viral latency.
Summary
KSHV non-coding RNAs play significant roles in the pathogenesis of KSHV-associated diseases. |
| doi_str_mv | 10.1007/s40588-018-0101-2 |
| format | Article |
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Herpesviruses are large DNA viruses whose genomes contain a number of genes producing non-coding RNAs, such as small RNA and long non-coding RNA. In this review, the expression and function of Kaposi’s sarcoma-associated herpesvirus (KSHV) non-coding RNAs are discussed.
Recent Findings
The KSHV genome contains at least 12 genes from which pre-microRNAs (miRNAs) are transcribed, and several genes producing long non-coding RNAs (lncRNAs). Polyadenylated nuclear RNA is a highly expressed viral lncRNA molecule in KSHV-infected cells and is necessary for KSHV replication. KSHV miRNAs are expressed predominantly during the latent phase of KSHV infection not only in cells but also in extracellular vesicles such as exosomes and virions. Identification of viral miRNA targets has revealed that KSHV miRNAs have various functions relating to oncogenesis, anti-apoptosis, angiogenesis, and migration of KSHV-infected cells. Some KSHV miRNAs regulate KSHV replication to maintain viral latency.
Summary
KSHV non-coding RNAs play significant roles in the pathogenesis of KSHV-associated diseases.</description><identifier>ISSN: 2196-5471</identifier><identifier>EISSN: 2196-5471</identifier><identifier>DOI: 10.1007/s40588-018-0101-2</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Angiogenesis ; Apoptosis ; Biomedical and Life Sciences ; Biomedicine ; Cell migration ; Deoxyribonucleic acid ; DNA ; DNA viruses ; Exosomes ; Genomes ; Latency ; Medical Microbiology ; miRNA ; Non-coding RNA ; Polyadenylation ; Replication ; Sarcoma ; Section Editor ; Topical Collection on Virology ; Tumorigenesis ; Virions ; Virology (A Nicola</subject><ispartof>Current clinical microbiology reports, 2018-12, Vol.5 (4), p.211-218</ispartof><rights>Springer Nature Switzerland AG 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c334t-680ebad8e33a5728946795a1f49f927ddb3f75f505c4a7ddcbfaf130c634a9e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40588-018-0101-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40588-018-0101-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Katano, Harutaka</creatorcontrib><title>Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs</title><title>Current clinical microbiology reports</title><addtitle>Curr Clin Micro Rpt</addtitle><description>Purpose of Review
Herpesviruses are large DNA viruses whose genomes contain a number of genes producing non-coding RNAs, such as small RNA and long non-coding RNA. In this review, the expression and function of Kaposi’s sarcoma-associated herpesvirus (KSHV) non-coding RNAs are discussed.
Recent Findings
The KSHV genome contains at least 12 genes from which pre-microRNAs (miRNAs) are transcribed, and several genes producing long non-coding RNAs (lncRNAs). Polyadenylated nuclear RNA is a highly expressed viral lncRNA molecule in KSHV-infected cells and is necessary for KSHV replication. KSHV miRNAs are expressed predominantly during the latent phase of KSHV infection not only in cells but also in extracellular vesicles such as exosomes and virions. Identification of viral miRNA targets has revealed that KSHV miRNAs have various functions relating to oncogenesis, anti-apoptosis, angiogenesis, and migration of KSHV-infected cells. Some KSHV miRNAs regulate KSHV replication to maintain viral latency.
Summary
KSHV non-coding RNAs play significant roles in the pathogenesis of KSHV-associated diseases.</description><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell migration</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA viruses</subject><subject>Exosomes</subject><subject>Genomes</subject><subject>Latency</subject><subject>Medical Microbiology</subject><subject>miRNA</subject><subject>Non-coding RNA</subject><subject>Polyadenylation</subject><subject>Replication</subject><subject>Sarcoma</subject><subject>Section Editor</subject><subject>Topical Collection on Virology</subject><subject>Tumorigenesis</subject><subject>Virions</subject><subject>Virology (A Nicola</subject><issn>2196-5471</issn><issn>2196-5471</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kM1Kw0AUhQdRsNQ-gLuA69H5zSTLUlpbLBW0rofpZKak2Eycm4jufA1fzycxIYJuXFzuPXDOufAhdEnJNSVE3YAgMsswof0QitkJGjGap1gKRU__3OdoAnAghFCuUpnKEdrO3-roAMpQJaYqkkVb2aYXwSd3pg5Qfn18QvJoog1Hg6cAwZamcUWydLF28FrGFpJNqLANRVntk4fNFC7QmTfP4CY_e4yeFvPtbInX97er2XSNLeeiwWlG3M4UmePcSMWyXKQql4Z6kfucqaLYca-kl0RaYTppd954yolNuTC5E3yMrobeOoaX1kGjD6GNVfdSM8pzynnKVeeig8vGABCd13Usjya-a0p0z08P_HTHT_f8NOsybMhA5632Lv42_x_6BvILc2U</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Katano, Harutaka</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20181201</creationdate><title>Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs</title><author>Katano, Harutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-680ebad8e33a5728946795a1f49f927ddb3f75f505c4a7ddcbfaf130c634a9e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell migration</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA viruses</topic><topic>Exosomes</topic><topic>Genomes</topic><topic>Latency</topic><topic>Medical Microbiology</topic><topic>miRNA</topic><topic>Non-coding RNA</topic><topic>Polyadenylation</topic><topic>Replication</topic><topic>Sarcoma</topic><topic>Section Editor</topic><topic>Topical Collection on Virology</topic><topic>Tumorigenesis</topic><topic>Virions</topic><topic>Virology (A Nicola</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katano, Harutaka</creatorcontrib><collection>CrossRef</collection><jtitle>Current clinical microbiology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katano, Harutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs</atitle><jtitle>Current clinical microbiology reports</jtitle><stitle>Curr Clin Micro Rpt</stitle><date>2018-12-01</date><risdate>2018</risdate><volume>5</volume><issue>4</issue><spage>211</spage><epage>218</epage><pages>211-218</pages><issn>2196-5471</issn><eissn>2196-5471</eissn><abstract>Purpose of Review
Herpesviruses are large DNA viruses whose genomes contain a number of genes producing non-coding RNAs, such as small RNA and long non-coding RNA. In this review, the expression and function of Kaposi’s sarcoma-associated herpesvirus (KSHV) non-coding RNAs are discussed.
Recent Findings
The KSHV genome contains at least 12 genes from which pre-microRNAs (miRNAs) are transcribed, and several genes producing long non-coding RNAs (lncRNAs). Polyadenylated nuclear RNA is a highly expressed viral lncRNA molecule in KSHV-infected cells and is necessary for KSHV replication. KSHV miRNAs are expressed predominantly during the latent phase of KSHV infection not only in cells but also in extracellular vesicles such as exosomes and virions. Identification of viral miRNA targets has revealed that KSHV miRNAs have various functions relating to oncogenesis, anti-apoptosis, angiogenesis, and migration of KSHV-infected cells. Some KSHV miRNAs regulate KSHV replication to maintain viral latency.
Summary
KSHV non-coding RNAs play significant roles in the pathogenesis of KSHV-associated diseases.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40588-018-0101-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Angiogenesis Apoptosis Biomedical and Life Sciences Biomedicine Cell migration Deoxyribonucleic acid DNA DNA viruses Exosomes Genomes Latency Medical Microbiology miRNA Non-coding RNA Polyadenylation Replication Sarcoma Section Editor Topical Collection on Virology Tumorigenesis Virions Virology (A Nicola |
| title | Expression and Function of Kaposi’s Sarcoma-Associated Herpesvirus Non-coding RNAs |
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