FAILURE OF REPEATED INJECTION SCLEROTHERAPY TO IMPROVE LONG-TERM SURVIVAL AFTER OESOPHAGEAL VARICEAL BLEEDING: A Five-year Prospective Controlled Clinical Trial
The role of sclerotherapy in long-term management after oesophageal variceal bleeding was assessed by comparing repeated sclerotherapy by means of a rigid oesophagoscope in 37 patients with control medical management in 38 patients. Varices were eradicated in 21 of the 22 patients analysed (95%) in...
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| Veröffentlicht in: | The Lancet (British edition) 1983-12, Vol.322 (8363), p.1328-1332 |
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| container_title | The Lancet (British edition) |
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| creator | Terblanche, John Kahn, Delawir Campbell, JohnA.H. Bornman, PhilipC Jonker, MichaelA.T. Wright, John Kirsch, Ralph |
| description | The role of sclerotherapy in long-term management after oesophageal variceal bleeding was assessed by comparing repeated sclerotherapy by means of a rigid oesophagoscope in 37 patients with control medical management in 38 patients. Varices were eradicated in 21 of the 22 patients analysed (95%) in the sclerotherapy group, but recurred in 13 of the 21 patients (average 21·5 months). Varices persisted in 13 of 14 surviving controls. The sclerotherapy patients had fewer recurrent bleeds than control patients (43 versus 73); the majority occurred before variceal eradication and were mild. However, there was no difference in survival in the two groups. The commonest cause of death was liver failure (37 patients). 32 complications occurred in 24 patients during 258 injections. Repeated sclerotherapy failed to improve survival in this trial, although varices were eradicated and recurrent variceal bleeds were prevented with adequate follow-up. |
| doi_str_mv | 10.1016/S0140-6736(83)91090-5 |
| format | Article |
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Varices were eradicated in 21 of the 22 patients analysed (95%) in the sclerotherapy group, but recurred in 13 of the 21 patients (average 21·5 months). Varices persisted in 13 of 14 surviving controls. The sclerotherapy patients had fewer recurrent bleeds than control patients (43 versus 73); the majority occurred before variceal eradication and were mild. However, there was no difference in survival in the two groups. The commonest cause of death was liver failure (37 patients). 32 complications occurred in 24 patients during 258 injections. Repeated sclerotherapy failed to improve survival in this trial, although varices were eradicated and recurrent variceal bleeds were prevented with adequate follow-up.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(83)91090-5</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Bleeding ; Esophagus ; Gastroenterology. Liver. Pancreas. Abdomen ; Liver ; Liver diseases ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Other diseases. Semiology ; Patients ; Sclerotherapy ; Survival ; Varicose veins</subject><ispartof>The Lancet (British edition), 1983-12, Vol.322 (8363), p.1328-1332</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><rights>Copyright Elsevier Limited Dec 10, 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c233t-34057a5ff9ecf89dc033bb2b4c1c1a8f29748a7456d078bf87b8d16f092c4bfb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673683910905$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9445371$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Terblanche, John</creatorcontrib><creatorcontrib>Kahn, Delawir</creatorcontrib><creatorcontrib>Campbell, JohnA.H.</creatorcontrib><creatorcontrib>Bornman, PhilipC</creatorcontrib><creatorcontrib>Jonker, MichaelA.T.</creatorcontrib><creatorcontrib>Wright, John</creatorcontrib><creatorcontrib>Kirsch, Ralph</creatorcontrib><title>FAILURE OF REPEATED INJECTION SCLEROTHERAPY TO IMPROVE LONG-TERM SURVIVAL AFTER OESOPHAGEAL VARICEAL BLEEDING: A Five-year Prospective Controlled Clinical Trial</title><title>The Lancet (British edition)</title><description>The role of sclerotherapy in long-term management after oesophageal variceal bleeding was assessed by comparing repeated sclerotherapy by means of a rigid oesophagoscope in 37 patients with control medical management in 38 patients. Varices were eradicated in 21 of the 22 patients analysed (95%) in the sclerotherapy group, but recurred in 13 of the 21 patients (average 21·5 months). Varices persisted in 13 of 14 surviving controls. The sclerotherapy patients had fewer recurrent bleeds than control patients (43 versus 73); the majority occurred before variceal eradication and were mild. However, there was no difference in survival in the two groups. The commonest cause of death was liver failure (37 patients). 32 complications occurred in 24 patients during 258 injections. Repeated sclerotherapy failed to improve survival in this trial, although varices were eradicated and recurrent variceal bleeds were prevented with adequate follow-up.</description><subject>Biological and medical sciences</subject><subject>Bleeding</subject><subject>Esophagus</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Patients</subject><subject>Sclerotherapy</subject><subject>Survival</subject><subject>Varicose veins</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNo9kd2O0zAQhS0EEqXwCEiW4AIuAnZs54cbZLJOG5RtojSt4MpyHEfyKpsUp7vSvg2Piru74mpmjj7NnNEB4D1GXzDC0dc9whQFUUyiTwn5nGKUooC9ACtMYxowGv96CVb_kdfgzbLcIIRohNgK_M15UR4aAascNqIWvBVXsNj9FFlbVDu4z0rRVO1WNLz-DdsKFtd1Ux0FLKvdJmhFcw33h-ZYHHkJee5nWIl9VW_5RnjlyJsiuzQ_SiGuit3mG-Qwt_cmeDDKwdrNy8nosxdgNk9nN4-j6WE22slqNcLWWTW-Ba8GNS7m3XNdg0Mu2mwblNWmyHgZ6JCQc0AoYrFiw5AaPSRprxEhXRd2VGONVTKEaUwTFVMW9ShOuiGJu6TH0YDSUNNu6MgafHjae3LznzuznOXNfOcmf1KGmCQsxiRlnvr4TKnFWxycmrRd5MnZW-UeZEopI55cg-9PmPGO761xctHWTNr01vmHZT9biZG8pCcf05OXaGRC5GN6kpF_arWFzw</recordid><startdate>19831210</startdate><enddate>19831210</enddate><creator>Terblanche, John</creator><creator>Kahn, Delawir</creator><creator>Campbell, JohnA.H.</creator><creator>Bornman, PhilipC</creator><creator>Jonker, MichaelA.T.</creator><creator>Wright, John</creator><creator>Kirsch, Ralph</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19831210</creationdate><title>FAILURE OF REPEATED INJECTION SCLEROTHERAPY TO IMPROVE LONG-TERM SURVIVAL AFTER OESOPHAGEAL VARICEAL BLEEDING: A Five-year Prospective Controlled Clinical Trial</title><author>Terblanche, John ; Kahn, Delawir ; Campbell, JohnA.H. ; Bornman, PhilipC ; Jonker, MichaelA.T. ; Wright, John ; Kirsch, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c233t-34057a5ff9ecf89dc033bb2b4c1c1a8f29748a7456d078bf87b8d16f092c4bfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Biological and medical sciences</topic><topic>Bleeding</topic><topic>Esophagus</topic><topic>Gastroenterology. 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| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1983-12, Vol.322 (8363), p.1328-1332 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Bleeding Esophagus Gastroenterology. Liver. Pancreas. Abdomen Liver Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Patients Sclerotherapy Survival Varicose veins |
| title | FAILURE OF REPEATED INJECTION SCLEROTHERAPY TO IMPROVE LONG-TERM SURVIVAL AFTER OESOPHAGEAL VARICEAL BLEEDING: A Five-year Prospective Controlled Clinical Trial |
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