Autoantigen-specific protection of non-obese diabetic mice from cyclophosphamide-accelerated diabetes by vaccination with dendritic cells

Dendritic cells (DCs) are professional antigen presenting cells involved in the initiation of primary immune responses and the preservation of peripheral tolerance. The aim of this study was to develop a DC vaccine for autoantigen-specific prevention of autoimmune diabetes. Splenocytes from diabetes...

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Veröffentlicht in:	Diabetologia 2003-10, Vol.46 (10), p.1357-1365
Hauptverfasser:	KRUEGER, T, WOHLRAB, U, KLUCKEN, M, SCHOTT, M, SEISSLER, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Autoantigens - immunology Autoimmune diseases Biological and medical sciences Bone marrow Cell Line Cyclophosphamide - pharmacology Cytokines Cytotoxicity Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - transplantation Diabetes Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - prevention & control Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epitopes Female Hypotheses Immunosuppressive Agents - pharmacology Insulin Interleukin-10 - pharmacology Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Mice, Inbred NOD NIH 3T3 Cells Obesity Prevention Vaccination - methods Vaccines
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