Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes

The aim of this analysis was to examine the long-term effects of pioglitazone or gliclazide addition to failing metformin monotherapy and pioglitazone or metformin addition to failing sulphonylurea monotherapy in patients with type 2 diabetes. Two 2-year, randomised, multicentre trials were performe...

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Veröffentlicht in:	Diabetologia 2005-06, Vol.48 (6), p.1093-1104
Hauptverfasser:	CHARBONNEL, B, SCHERNTHANER, G, BRUNETTI, P, MATTHEWS, D. R, URQUHART, R, TAN, M. H, HANEFELD, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences C-Peptide - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Drug Therapy, Combination Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Gliclazide - therapeutic use Glycated Hemoglobin A - metabolism Humans Hypoglycemic Agents - therapeutic use Lipids - blood Male Medical sciences Metformin - therapeutic use Middle Aged Reproducibility of Results Safety Thiazolidinediones - adverse effects Thiazolidinediones - therapeutic use Treatment Failure Treatment Outcome
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