Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes

We analysed the contribution of the lymphoid protein tyrosine phosphatase (LYP) Arg620Trp variant (which corresponds to the PTPN22 C1858T polymorphism) to the emergence of beta-cell-specific humoral autoimmunity and progression to type 1 diabetes in man. We also explored the heterogeneity in the dis...

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Veröffentlicht in:	Diabetologia 2006-06, Vol.49 (6), p.1198-1208
Hauptverfasser:	HERMANN, R, LIPPONEN, K, KIVINIEMI, M, KAKKO, T, VEIJOLA, R, SIMELL, O, KNIP, M, ILONEN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Amino Acid Substitution Antigens Arginine Autoantibodies - blood Biological and medical sciences Child Child, Preschool Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Disease Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene loci Genetic Variation Glutamate Decarboxylase - immunology Haplotypes HLA-DQ Antigens - immunology Humans Infant Infant, Newborn Insulin Insulin Antibodies - blood Kinases Male Mass Screening Medical sciences Nuclear Family Pediatrics Phosphatase Polymorphism Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases - genetics Proteins Sex Characteristics T cell receptors Tryptophan
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