Erythromycin ameliorates renal injury via anti-inflammatory effects in experimental diabetic rats

Recent studies have shown that the inflammatory process is involved in the pathogenesis of diabetic nephropathy. Fourteen-membered ring macrolides, including erythromycin, have anti-inflammatory, as well as antibacterial effects. The aim of this study was to investigate the renoprotective effects of...

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Veröffentlicht in:	Diabetologia 2005-11, Vol.48 (11), p.2402-2411
Hauptverfasser:	TONE, A, SHIKATA, K, SHIKATA, Y, WADA, J, MAKINO, H, SASAKI, M, OHGA, S, YOZAI, K, NISHISHITA, S, USUI, H, NAGASE, R, OGAWA, D, OKADA, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - drug therapy Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Blood pressure Chemokine CCL2 - drug effects Chemokine CCL2 - genetics Chemokines Collagen Type IV - drug effects Collagen Type IV - genetics Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Diabetic Nephropathies - etiology Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control Diabetic nephropathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Erythromycin - pharmacology Etiopathogenesis. Screening. Investigations. Target tissue resistance Extracellular matrix Injuries Injuries of the urinary system. Foreign bodies. Diseases due to physical agents Intercellular Adhesion Molecule-1 - metabolism Kidney - drug effects Kidney - pathology Kidney - physiology Kidney diseases Kidneys Kinases Ligands Macrophages - drug effects Medical sciences Nephrology. Urinary tract diseases NF-kappa B - drug effects NF-kappa B - metabolism Pathogenesis Proteins Rats Rats, Sprague-Dawley Streptozocin - toxicity Transcription Factor RelA - drug effects Transcription Factor RelA - metabolism Transforming Growth Factor beta - drug effects Transforming Growth Factor beta - genetics Transforming Growth Factor beta1 Traumas. Diseases due to physical agents Urinary system involvement in other diseases. Miscellaneous
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