Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

Aims/hypothesis Exendin-4 is a 39 amino acid agonist of the glucagon-like peptide receptor and has been approved for treatment of type 2 diabetes. Many reports describe an increased incidence of acute pancreatitis in humans treated with exendin-4 (exenatide). Previous studies have evaluated the effe...

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Veröffentlicht in:	Diabetologia 2010-01, Vol.53 (1), p.153-159
Hauptverfasser:	Nachnani, J. S, Bulchandani, D. G, Nookala, A, Herndon, B, Molteni, A, Pandya, P, Taylor, R, Quinn, T, Weide, L, Alba, L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - blood Alanine Transaminase - blood Amylases - blood Amylases - drug effects Animals Aspartate Aminotransferases - blood Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Body Weight - drug effects Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance FDA approval Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Glucagon Glucose Hepatology Human Physiology Humans Hypoglycemic Agents - pharmacology Inflammation Insulin - blood Insulin resistance Internal Medicine Laboratory animals Lipase - blood Lipase - drug effects Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical research Medical sciences Medicine Medicine & Public Health Metabolic Diseases Other diseases. Semiology Pancreas Pancreas - cytology Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Pancreatitis Pancreatitis - chemically induced Pancreatitis - pathology Peptides Peptides - pharmacology Rats Rats, Sprague-Dawley Venoms - pharmacology
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