Cupping of the optic disk after methanol poisoning
PurposeTo assess the frequency and significance of optic disk cupping after methanol poisoning.MethodsWe retrospectively reviewed the medical records of 50 consecutive patients with methanol poisoning, including visual acuity, pupillary reaction, and optic disk features such as the presence and degr...
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| Veröffentlicht in: | British journal of ophthalmology 2015-09, Vol.99 (9), p.1220-1223 |
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| creator | Galvez-Ruiz, Alberto Elkhamary, Sahar M Asghar, Nasira Bosley, Thomas M |
| description | PurposeTo assess the frequency and significance of optic disk cupping after methanol poisoning.MethodsWe retrospectively reviewed the medical records of 50 consecutive patients with methanol poisoning, including visual acuity, pupillary reaction, and optic disk features such as the presence and degree of cupping. All patients were examined in the chronic phase after optic nerve damage.ResultsOptic disk cupping ≥0.8 c/d was present in at least one eye of 22 of these 50 patients (43/100 eyes). Severity of cupping was statistically symmetric in the two eyes, and increasing severity of cupping was correlated with worse visual acuity (p=0.007) and increasing visual field loss. Degree of cupping was significantly correlated with increasing patient age but not with putaminal necrosis.ConclusionsOptic disk cupping after methanol poisoning may be more common than previously recognised. Cupping in this setting may reflect toxicity of methanol metabolites to axons and glial cells in the prelaminar, laminar and retrolaminar regions, and seems to be important as a marker for worse optic nerve damage. |
| doi_str_mv | 10.1136/bjophthalmol-2014-306354 |
| format | Article |
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All patients were examined in the chronic phase after optic nerve damage.ResultsOptic disk cupping ≥0.8 c/d was present in at least one eye of 22 of these 50 patients (43/100 eyes). Severity of cupping was statistically symmetric in the two eyes, and increasing severity of cupping was correlated with worse visual acuity (p=0.007) and increasing visual field loss. Degree of cupping was significantly correlated with increasing patient age but not with putaminal necrosis.ConclusionsOptic disk cupping after methanol poisoning may be more common than previously recognised. Cupping in this setting may reflect toxicity of methanol metabolites to axons and glial cells in the prelaminar, laminar and retrolaminar regions, and seems to be important as a marker for worse optic nerve damage.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2014-306354</identifier><identifier>PMID: 25777817</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adolescent ; Adult ; Age Factors ; Alcohol ; Atrophy ; Female ; Gangrene ; Glaucoma ; Hospitals ; Humans ; Male ; Medical imaging ; Medical records ; Methanol - poisoning ; Middle Aged ; Ophthalmology ; Optic Disk - drug effects ; Optic Disk - pathology ; Optic nerve ; Patients ; Poisoning ; Retinal Diseases - chemically induced ; Retinal Diseases - physiopathology ; Retrospective Studies ; Solvents - poisoning ; Vision Disorders - chemically induced ; Vision Disorders - physiopathology ; Visual Acuity - physiology ; Visual Fields - physiology ; Young Adult</subject><ispartof>British journal of ophthalmology, 2015-09, Vol.99 (9), p.1220-1223</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b420t-db1f63add7716a736e5f2991bdc13a5e3e4d620f58ddd2b880307484bf622f2c3</citedby><cites>FETCH-LOGICAL-b420t-db1f63add7716a736e5f2991bdc13a5e3e4d620f58ddd2b880307484bf622f2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/99/9/1220.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/99/9/1220.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25777817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galvez-Ruiz, Alberto</creatorcontrib><creatorcontrib>Elkhamary, Sahar M</creatorcontrib><creatorcontrib>Asghar, Nasira</creatorcontrib><creatorcontrib>Bosley, Thomas M</creatorcontrib><title>Cupping of the optic disk after methanol poisoning</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>PurposeTo assess the frequency and significance of optic disk cupping after methanol poisoning.MethodsWe retrospectively reviewed the medical records of 50 consecutive patients with methanol poisoning, including visual acuity, pupillary reaction, and optic disk features such as the presence and degree of cupping. All patients were examined in the chronic phase after optic nerve damage.ResultsOptic disk cupping ≥0.8 c/d was present in at least one eye of 22 of these 50 patients (43/100 eyes). Severity of cupping was statistically symmetric in the two eyes, and increasing severity of cupping was correlated with worse visual acuity (p=0.007) and increasing visual field loss. Degree of cupping was significantly correlated with increasing patient age but not with putaminal necrosis.ConclusionsOptic disk cupping after methanol poisoning may be more common than previously recognised. Cupping in this setting may reflect toxicity of methanol metabolites to axons and glial cells in the prelaminar, laminar and retrolaminar regions, and seems to be important as a marker for worse optic nerve damage.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Alcohol</subject><subject>Atrophy</subject><subject>Female</subject><subject>Gangrene</subject><subject>Glaucoma</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical records</subject><subject>Methanol - poisoning</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Optic Disk - drug effects</subject><subject>Optic Disk - pathology</subject><subject>Optic nerve</subject><subject>Patients</subject><subject>Poisoning</subject><subject>Retinal Diseases - chemically induced</subject><subject>Retinal Diseases - physiopathology</subject><subject>Retrospective Studies</subject><subject>Solvents - poisoning</subject><subject>Vision Disorders - chemically induced</subject><subject>Vision Disorders - physiopathology</subject><subject>Visual Acuity - physiology</subject><subject>Visual Fields - physiology</subject><subject>Young Adult</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkE1LxDAQhoMo7rr6FyTguZpJ0iQ9yuIXLHjRc2iaxG1tm9q0B_-9Wari0dMww_POCw9CGMg1ABM3pgnDftqXbRfajBLgGSOC5fwIrYELlU6yOEZrQojMAASs0FmMTVqpAHmKVjSXUiqQa0S38zDU_RsOHk97h8Mw1RW2dXzHpZ_ciDuXevrQ4iHUMfQJPUcnvmyju_ieG_R6f_eyfcx2zw9P29tdZjglU2YNeMFKa6UEUUomXO5pUYCxFbAyd8xxKyjxubLWUqMUYURyxY0XlHpasQ26Wv4OY_iYXZx0E-axT5WaApMF4USpRKmFqsYQ4-i8Hsa6K8dPDUQfZOm_svRBll5kpejld8FsOmd_gz92EsAWwHTN_99-AaI8eSk</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Galvez-Ruiz, Alberto</creator><creator>Elkhamary, Sahar M</creator><creator>Asghar, Nasira</creator><creator>Bosley, Thomas M</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150901</creationdate><title>Cupping of the optic disk after methanol poisoning</title><author>Galvez-Ruiz, Alberto ; Elkhamary, Sahar M ; Asghar, Nasira ; Bosley, Thomas M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b420t-db1f63add7716a736e5f2991bdc13a5e3e4d620f58ddd2b880307484bf622f2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Alcohol</topic><topic>Atrophy</topic><topic>Female</topic><topic>Gangrene</topic><topic>Glaucoma</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical records</topic><topic>Methanol - poisoning</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Optic Disk - drug effects</topic><topic>Optic Disk - pathology</topic><topic>Optic nerve</topic><topic>Patients</topic><topic>Poisoning</topic><topic>Retinal Diseases - chemically induced</topic><topic>Retinal Diseases - physiopathology</topic><topic>Retrospective Studies</topic><topic>Solvents - poisoning</topic><topic>Vision Disorders - chemically induced</topic><topic>Vision Disorders - physiopathology</topic><topic>Visual Acuity - physiology</topic><topic>Visual Fields - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galvez-Ruiz, Alberto</creatorcontrib><creatorcontrib>Elkhamary, Sahar M</creatorcontrib><creatorcontrib>Asghar, Nasira</creatorcontrib><creatorcontrib>Bosley, Thomas M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galvez-Ruiz, Alberto</au><au>Elkhamary, Sahar M</au><au>Asghar, Nasira</au><au>Bosley, Thomas M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cupping of the optic disk after methanol poisoning</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>99</volume><issue>9</issue><spage>1220</spage><epage>1223</epage><pages>1220-1223</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract>PurposeTo assess the frequency and significance of optic disk cupping after methanol poisoning.MethodsWe retrospectively reviewed the medical records of 50 consecutive patients with methanol poisoning, including visual acuity, pupillary reaction, and optic disk features such as the presence and degree of cupping. All patients were examined in the chronic phase after optic nerve damage.ResultsOptic disk cupping ≥0.8 c/d was present in at least one eye of 22 of these 50 patients (43/100 eyes). Severity of cupping was statistically symmetric in the two eyes, and increasing severity of cupping was correlated with worse visual acuity (p=0.007) and increasing visual field loss. Degree of cupping was significantly correlated with increasing patient age but not with putaminal necrosis.ConclusionsOptic disk cupping after methanol poisoning may be more common than previously recognised. Cupping in this setting may reflect toxicity of methanol metabolites to axons and glial cells in the prelaminar, laminar and retrolaminar regions, and seems to be important as a marker for worse optic nerve damage.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25777817</pmid><doi>10.1136/bjophthalmol-2014-306354</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Alcohol Atrophy Female Gangrene Glaucoma Hospitals Humans Male Medical imaging Medical records Methanol - poisoning Middle Aged Ophthalmology Optic Disk - drug effects Optic Disk - pathology Optic nerve Patients Poisoning Retinal Diseases - chemically induced Retinal Diseases - physiopathology Retrospective Studies Solvents - poisoning Vision Disorders - chemically induced Vision Disorders - physiopathology Visual Acuity - physiology Visual Fields - physiology Young Adult |
| title | Cupping of the optic disk after methanol poisoning |
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