Exploring the Role of Enzalutamide in Combination with Radiation Therapy: An In Vitro Study

Androgen receptor plays a key role in prostate cancer development and is a causative agent of its radio-resistance. The present study investigated the potential radio-sensitizing effect of enzalutamide, a second-generation anti-androgen, in human prostate cancer cells. The radio-sensitizing effect o...

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Veröffentlicht in:	Anticancer research 2018-06, Vol.38 (6), p.3487-3492
Hauptverfasser:	Triggiani, Luca, Colosini, Antonella, Buglione, Michela, Pasinetti, Nadia, Orizio, Flavia, Bardoscia, Lilia, Borghetti, Paolo, Maddalo, Marta, Spiazzi, Luigi, Magrini, Stefano Maria, Bresciani, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Androgens Antineoplastic Agents - pharmacology Background radiation Cancer Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell survival Cell Survival - drug effects Cell Survival - radiation effects Deoxyribonucleic acid DNA DNA repair Dose-Response Relationship, Radiation Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - radiation effects Histones - metabolism Humans Ionizing radiation Male Phenylthiohydantoin - analogs & derivatives Phenylthiohydantoin - pharmacology Prostate cancer Prostatic Neoplasms - pathology Radiation therapy Radiation-Sensitizing Agents - pharmacology Sensitizing
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