Effect of Fabrication Parameters on the Physiochemical Properties of Amphiphilic Chitosan Nanoparticles
The majority of anticancer drugs are hydrophobic and there is a big challenge to deliver them effectively to its target. One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nano...
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| Veröffentlicht in: | Iranian journal of science and technology. Transaction A, Science Science, 2018-12, Vol.42 (4), p.1873-1879 |
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| container_title | Iranian journal of science and technology. Transaction A, Science |
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| creator | Motiei, Marjan Kashanian, Soheila Azandaryani, Abbas H. |
| description | The majority of anticancer drugs are hydrophobic and there is a big challenge to deliver them effectively to its target. One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nanoparticles by a two-step method, i.e., oil-in-water emulsion/ionic gelation technique to prepare amphiphilic chitosan nanoparticles (ACNs). Due to the importance of physicochemical characteristics of ACNs especially nanoparticle size on cell uptake, the present work has focused on the evaluation of some parameters’ effect such as, sonication power and time, cross-linker and stabilizer concentrations on ACNs size. The success of PL encapsulation was confirmed by Fourier transform infrared spectroscopy and the effect of the parameters were evaluated by laser light scattering and scanning electron microscopy. It was observed that each parameter affected nanoparticle size and morphology with an optimum limit. Thus, this study confirms the importance of preparation parameters on the physicochemical characteristics of ACNs. |
| doi_str_mv | 10.1007/s40995-017-0152-x |
| format | Article |
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One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nanoparticles by a two-step method, i.e., oil-in-water emulsion/ionic gelation technique to prepare amphiphilic chitosan nanoparticles (ACNs). Due to the importance of physicochemical characteristics of ACNs especially nanoparticle size on cell uptake, the present work has focused on the evaluation of some parameters’ effect such as, sonication power and time, cross-linker and stabilizer concentrations on ACNs size. The success of PL encapsulation was confirmed by Fourier transform infrared spectroscopy and the effect of the parameters were evaluated by laser light scattering and scanning electron microscopy. It was observed that each parameter affected nanoparticle size and morphology with an optimum limit. Thus, this study confirms the importance of preparation parameters on the physicochemical characteristics of ACNs.</description><identifier>ISSN: 1028-6276</identifier><identifier>EISSN: 2364-1819</identifier><identifier>DOI: 10.1007/s40995-017-0152-x</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acids ; Antitumor agents ; Cancer therapies ; Cell size ; Chemistry/Food Science ; Chitosan ; Crosslinking ; Drug delivery systems ; Earth Sciences ; Encapsulation ; Engineering ; Fabrication ; Fourier transforms ; Gelation ; Hydrophobicity ; Infrared spectroscopy ; Life Sciences ; Light scattering ; Materials Science ; Morphology ; Nanoparticles ; Palmitic acid ; Parameters ; Particle size ; Physics ; Physiochemistry ; Research Paper ; Scanning electron microscopy ; Sonication ; Spectrum analysis ; Surfactants ; Toxicity ; Ultrasonic imaging</subject><ispartof>Iranian journal of science and technology. 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Transaction A, Science</title><addtitle>Iran J Sci Technol Trans Sci</addtitle><description>The majority of anticancer drugs are hydrophobic and there is a big challenge to deliver them effectively to its target. One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nanoparticles by a two-step method, i.e., oil-in-water emulsion/ionic gelation technique to prepare amphiphilic chitosan nanoparticles (ACNs). Due to the importance of physicochemical characteristics of ACNs especially nanoparticle size on cell uptake, the present work has focused on the evaluation of some parameters’ effect such as, sonication power and time, cross-linker and stabilizer concentrations on ACNs size. The success of PL encapsulation was confirmed by Fourier transform infrared spectroscopy and the effect of the parameters were evaluated by laser light scattering and scanning electron microscopy. It was observed that each parameter affected nanoparticle size and morphology with an optimum limit. Thus, this study confirms the importance of preparation parameters on the physicochemical characteristics of ACNs.</description><subject>Acids</subject><subject>Antitumor agents</subject><subject>Cancer therapies</subject><subject>Cell size</subject><subject>Chemistry/Food Science</subject><subject>Chitosan</subject><subject>Crosslinking</subject><subject>Drug delivery systems</subject><subject>Earth Sciences</subject><subject>Encapsulation</subject><subject>Engineering</subject><subject>Fabrication</subject><subject>Fourier transforms</subject><subject>Gelation</subject><subject>Hydrophobicity</subject><subject>Infrared spectroscopy</subject><subject>Life Sciences</subject><subject>Light scattering</subject><subject>Materials Science</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Palmitic acid</subject><subject>Parameters</subject><subject>Particle size</subject><subject>Physics</subject><subject>Physiochemistry</subject><subject>Research Paper</subject><subject>Scanning electron microscopy</subject><subject>Sonication</subject><subject>Spectrum analysis</subject><subject>Surfactants</subject><subject>Toxicity</subject><subject>Ultrasonic 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Transaction A, Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motiei, Marjan</au><au>Kashanian, Soheila</au><au>Azandaryani, Abbas H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Fabrication Parameters on the Physiochemical Properties of Amphiphilic Chitosan Nanoparticles</atitle><jtitle>Iranian journal of science and technology. Transaction A, Science</jtitle><stitle>Iran J Sci Technol Trans Sci</stitle><date>2018-12-01</date><risdate>2018</risdate><volume>42</volume><issue>4</issue><spage>1873</spage><epage>1879</epage><pages>1873-1879</pages><issn>1028-6276</issn><eissn>2364-1819</eissn><abstract>The majority of anticancer drugs are hydrophobic and there is a big challenge to deliver them effectively to its target. One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nanoparticles by a two-step method, i.e., oil-in-water emulsion/ionic gelation technique to prepare amphiphilic chitosan nanoparticles (ACNs). Due to the importance of physicochemical characteristics of ACNs especially nanoparticle size on cell uptake, the present work has focused on the evaluation of some parameters’ effect such as, sonication power and time, cross-linker and stabilizer concentrations on ACNs size. The success of PL encapsulation was confirmed by Fourier transform infrared spectroscopy and the effect of the parameters were evaluated by laser light scattering and scanning electron microscopy. It was observed that each parameter affected nanoparticle size and morphology with an optimum limit. Thus, this study confirms the importance of preparation parameters on the physicochemical characteristics of ACNs.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40995-017-0152-x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Iranian journal of science and technology. Transaction A, Science, 2018-12, Vol.42 (4), p.1873-1879 |
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| subjects | Acids Antitumor agents Cancer therapies Cell size Chemistry/Food Science Chitosan Crosslinking Drug delivery systems Earth Sciences Encapsulation Engineering Fabrication Fourier transforms Gelation Hydrophobicity Infrared spectroscopy Life Sciences Light scattering Materials Science Morphology Nanoparticles Palmitic acid Parameters Particle size Physics Physiochemistry Research Paper Scanning electron microscopy Sonication Spectrum analysis Surfactants Toxicity Ultrasonic imaging |
| title | Effect of Fabrication Parameters on the Physiochemical Properties of Amphiphilic Chitosan Nanoparticles |
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