GnRH analog is ineffective in increasing adult height in girls with puberty onset after 7 years of age: a systematic review and meta-analysis
Objective We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. Methods We performed a systematic review and included controlled studies in which girls with earl...
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| Veröffentlicht in: | European journal of endocrinology 2018-12, Vol.179 (6), p.381-390 |
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| creator | Franzini, I A Yamamoto, F M Bolfi, F Antonini, S R Nunes-Nogueira, V S |
| description | Objective We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. Methods We performed a systematic review and included controlled studies in which girls with early puberty (EP) were assigned to the GnRH analog or no treatment groups. The primary outcome analyzed was AH. Search strategies were applied to the MEDLINE, EMBASE, LILACS and CENTRAL databases. Results We identified 1514 references, and six studies fulfilled our eligibility criteria. Two studies were randomized and four were not randomized. At the baseline of each trial, height, chronological age, bone age, predicted AH (PAH) and target height (TH) were equal between the groups. All studies used intramuscular triptorelin every 28 days in the intervention groups. The mean duration of the therapy was 2 years. Meta-analysis of AH among the six studies (comprising 332 girls) showed no significant difference between the groups (mean difference = 0.50 cm, 95% confidence interval = −0.72 to 1.73 cm, I 2 = 0%). In a sub-group analysis based on PAH ( |
| doi_str_mv | 10.1530/EJE-18-0473 |
| format | Article |
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Methods We performed a systematic review and included controlled studies in which girls with early puberty (EP) were assigned to the GnRH analog or no treatment groups. The primary outcome analyzed was AH. Search strategies were applied to the MEDLINE, EMBASE, LILACS and CENTRAL databases. Results We identified 1514 references, and six studies fulfilled our eligibility criteria. Two studies were randomized and four were not randomized. At the baseline of each trial, height, chronological age, bone age, predicted AH (PAH) and target height (TH) were equal between the groups. All studies used intramuscular triptorelin every 28 days in the intervention groups. The mean duration of the therapy was 2 years. Meta-analysis of AH among the six studies (comprising 332 girls) showed no significant difference between the groups (mean difference = 0.50 cm, 95% confidence interval = −0.72 to 1.73 cm, I 2 = 0%). In a sub-group analysis based on PAH (<155 cm and <TH; <TH, but >155 cm and equal to TH), there was no difference in average AH between the groups. The quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation approach was low. Conclusion We found no evidence from controlled experimental and observational studies that compared with no treatment, the use of GnRH analogs improved AH in girls with EP.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-18-0473</identifier><identifier>PMID: 30324797</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Adult ; Age ; Body height ; Body Height - drug effects ; Body Height - physiology ; Child ; Clinical Study ; Female ; Gonadotropin-releasing hormone ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - pharmacology ; Gonadotropins ; Humans ; Meta-analysis ; Pituitary (anterior) ; Puberty ; Puberty - drug effects ; Puberty - physiology ; Systematic review</subject><ispartof>European journal of endocrinology, 2018-12, Vol.179 (6), p.381-390</ispartof><rights>2018 European Society of Endocrinology</rights><rights>Copyright BioScientifica Ltd. Dec 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b396t-94aed3398ce4d30a990af61040b487986c20d3130fae12aa2e7bf35a5ef11df03</citedby><cites>FETCH-LOGICAL-b396t-94aed3398ce4d30a990af61040b487986c20d3130fae12aa2e7bf35a5ef11df03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30324797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franzini, I A</creatorcontrib><creatorcontrib>Yamamoto, F M</creatorcontrib><creatorcontrib>Bolfi, F</creatorcontrib><creatorcontrib>Antonini, S R</creatorcontrib><creatorcontrib>Nunes-Nogueira, V S</creatorcontrib><title>GnRH analog is ineffective in increasing adult height in girls with puberty onset after 7 years of age: a systematic review and meta-analysis</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Objective We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. Methods We performed a systematic review and included controlled studies in which girls with early puberty (EP) were assigned to the GnRH analog or no treatment groups. The primary outcome analyzed was AH. Search strategies were applied to the MEDLINE, EMBASE, LILACS and CENTRAL databases. Results We identified 1514 references, and six studies fulfilled our eligibility criteria. Two studies were randomized and four were not randomized. At the baseline of each trial, height, chronological age, bone age, predicted AH (PAH) and target height (TH) were equal between the groups. All studies used intramuscular triptorelin every 28 days in the intervention groups. The mean duration of the therapy was 2 years. Meta-analysis of AH among the six studies (comprising 332 girls) showed no significant difference between the groups (mean difference = 0.50 cm, 95% confidence interval = −0.72 to 1.73 cm, I 2 = 0%). In a sub-group analysis based on PAH (<155 cm and <TH; <TH, but >155 cm and equal to TH), there was no difference in average AH between the groups. The quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation approach was low. Conclusion We found no evidence from controlled experimental and observational studies that compared with no treatment, the use of GnRH analogs improved AH in girls with EP.</description><subject>Adult</subject><subject>Age</subject><subject>Body height</subject><subject>Body Height - drug effects</subject><subject>Body Height - physiology</subject><subject>Child</subject><subject>Clinical Study</subject><subject>Female</subject><subject>Gonadotropin-releasing hormone</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Gonadotropins</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Pituitary (anterior)</subject><subject>Puberty</subject><subject>Puberty - drug effects</subject><subject>Puberty - physiology</subject><subject>Systematic review</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2L1EAQhhtR3HH05F0KPC7R6nRPPrzJMu4qC4IoeAuVpDrTy0wydnV2yY_wP9vDrB6Fgiqoh7eKR6nXGt_pjcH32y_bTFcZ2tI8USttyzorKvPzqVphhTazhTUX6oXIHaJOMz5XFwZNnrhypX5fj99ugEbaTwN4AT-yc9xFf89pTtUFJvHjANTP-wg79sMunlaDD3uBBx93cJxbDnGBaRSOQC5ygBIWpiAwOaCBPwCBLBL5QNF3EPje80M628OBI2Wn-4t4eameOdoLv3rsa_Xj0_b71U12-_X689XH26w1dRGz2hL3xtRVx7Y3SHWN5AqNFltblXVVdDn2Rht0xDonyrlsndnQhp3WvUOzVm_Puccw_ZpZYnM3zSE9IU2uTYF5aZKptbo8U12YRAK75hj8gcLSaGxO6pukvtFVc1Kf6DePmXN74P4f-9d1AvQZaP0knecxeuc7-m_oHw4-j-c</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Franzini, I A</creator><creator>Yamamoto, F M</creator><creator>Bolfi, F</creator><creator>Antonini, S R</creator><creator>Nunes-Nogueira, V S</creator><general>Bioscientifica Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201812</creationdate><title>GnRH analog is ineffective in increasing adult height in girls with puberty onset after 7 years of age: a systematic review and meta-analysis</title><author>Franzini, I A ; Yamamoto, F M ; Bolfi, F ; Antonini, S R ; Nunes-Nogueira, V S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b396t-94aed3398ce4d30a990af61040b487986c20d3130fae12aa2e7bf35a5ef11df03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Age</topic><topic>Body height</topic><topic>Body Height - drug effects</topic><topic>Body Height - physiology</topic><topic>Child</topic><topic>Clinical Study</topic><topic>Female</topic><topic>Gonadotropin-releasing hormone</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gonadotropins</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Pituitary (anterior)</topic><topic>Puberty</topic><topic>Puberty - drug effects</topic><topic>Puberty - physiology</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franzini, I A</creatorcontrib><creatorcontrib>Yamamoto, F M</creatorcontrib><creatorcontrib>Bolfi, F</creatorcontrib><creatorcontrib>Antonini, S R</creatorcontrib><creatorcontrib>Nunes-Nogueira, V S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franzini, I A</au><au>Yamamoto, F M</au><au>Bolfi, F</au><au>Antonini, S R</au><au>Nunes-Nogueira, V S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GnRH analog is ineffective in increasing adult height in girls with puberty onset after 7 years of age: a systematic review and meta-analysis</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>179</volume><issue>6</issue><spage>381</spage><epage>390</epage><pages>381-390</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>Objective We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. Methods We performed a systematic review and included controlled studies in which girls with early puberty (EP) were assigned to the GnRH analog or no treatment groups. The primary outcome analyzed was AH. Search strategies were applied to the MEDLINE, EMBASE, LILACS and CENTRAL databases. Results We identified 1514 references, and six studies fulfilled our eligibility criteria. Two studies were randomized and four were not randomized. At the baseline of each trial, height, chronological age, bone age, predicted AH (PAH) and target height (TH) were equal between the groups. All studies used intramuscular triptorelin every 28 days in the intervention groups. The mean duration of the therapy was 2 years. Meta-analysis of AH among the six studies (comprising 332 girls) showed no significant difference between the groups (mean difference = 0.50 cm, 95% confidence interval = −0.72 to 1.73 cm, I 2 = 0%). In a sub-group analysis based on PAH (<155 cm and <TH; <TH, but >155 cm and equal to TH), there was no difference in average AH between the groups. The quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation approach was low. Conclusion We found no evidence from controlled experimental and observational studies that compared with no treatment, the use of GnRH analogs improved AH in girls with EP.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>30324797</pmid><doi>10.1530/EJE-18-0473</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Body height Body Height - drug effects Body Height - physiology Child Clinical Study Female Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Gonadotropins Humans Meta-analysis Pituitary (anterior) Puberty Puberty - drug effects Puberty - physiology Systematic review |
| title | GnRH analog is ineffective in increasing adult height in girls with puberty onset after 7 years of age: a systematic review and meta-analysis |
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