Direct construction of benzimidazo[l,2- c ]quinazolin-6-ones via metal-free oxidative C–C bond cleavage
A highly regioselective C–C bond cleavage/amination of isatins has been developed for the synthesis of benzimidazo[1,2- c ]quinazolin-6-ones by reacting with o -phenylene diamines. This practical transition-metal-free method is operationally simple, enabling the C–C bond cleavage and triple C–N bond...
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Veröffentlicht in: | Organic Chemistry Frontiers 2018-12, Vol.5 (23), p.3464-3468 |
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creator | Li, Ping-Gui Yan, Cheng Zhu, Shuai Liu, Shu-Hui Zou, Liang-Hua |
description | A highly regioselective C–C bond cleavage/amination of isatins has been developed for the synthesis of benzimidazo[1,2- c ]quinazolin-6-ones by reacting with o -phenylene diamines. This practical transition-metal-free method is operationally simple, enabling the C–C bond cleavage and triple C–N bond formation, wherein molecular oxygen is the sole required oxidant. |
doi_str_mv | 10.1039/C8QO01039K |
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source | Royal Society Of Chemistry Journals 2008- |
subjects | Amination Chemical bonds Cleavage Crystallography Diamines Ductile-brittle transition Fracture mechanics Metals Organic chemistry Oxygen Transition metals |
title | Direct construction of benzimidazo[l,2- c ]quinazolin-6-ones via metal-free oxidative C–C bond cleavage |
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