Synthesis and cellular characterization of various nano-assemblies of cell penetrating peptide-epirubicin-polyglutamate conjugates for the enhancement of antitumor activity

A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the antitumor activity of epirubicin (EPR). Various amphiphilic CPPs were synthesized by solid phase peptide synthesis method and were chemically conjugated to EPR. Their cor...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2018-12, Vol.46 (8), p.1572-1585
Hauptverfasser:	Mohammadi, Samaneh, Zakeri-Milani, Parvin, Golkar, Nasim, Farkhani, Samad Mussa, Shirani, Ali, Shahbazi Mojarrad, Javid, Nokhodchi, Ali, Valizadeh, Hadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Binding Cell penetrating peptides Cell-Penetrating Peptides - chemical synthesis Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - pharmacology Conjugation Cytotoxicity drug delivery Epirubicin Epirubicin - chemical synthesis Epirubicin - chemistry Epirubicin - pharmacology Flow cytometry Fluorescence glutamate Humans Intracellular MCF-7 Cells Nanoconjugates - chemistry Nanoconjugates - therapeutic use Nanoparticles Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Organic chemistry Peptide synthesis Peptides Polyanions Polyelectrolytes Polyglutamic Acid - chemical synthesis Polyglutamic Acid - chemistry Polyglutamic Acid - pharmacology solid phase peptide synthesis Solid phases Synthesis Toxicity Tumor cells
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