Tocilizumab, a Humanized Monoclonal Antibody Against the Interleukin-6 Receptor, Inhibits High Glucose-Induced Vascular Smooth Muscle Cell Migration Through Mitogen-Activated Protein Kinase Signaling Pathways

Rheumatoid arthritis (RA) with diabetes increases the risk of cardiovascular diseases. Interleukin-6 (IL-6) promotes the disease activity of RA and insulin resistance. This study aimed to evaluate the potential effects and molecular mechanisms of IL-6 blocker, tocilizumab, in atherosclerosis with di...

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Veröffentlicht in:	Journal of interferon & cytokine research 2018-11, Vol.38 (11), p.510-516
Hauptverfasser:	Wu, Tao-Cheng, Chiang, Chih-Yao, Chan, Jenq-Shyong, Lee, Chiu-Yang, Leu, Hsin-Bang, Huang, Po-Hsun, Chen, Jia-Shiong, Lin, Shing-Jong, Chen, Jaw-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adhesion tests Aorta Arteriosclerosis Arthritis Atherosclerosis Cardiovascular disease Cardiovascular diseases Cell adhesion Cell adhesion & migration Cell culture Cell migration Cytokines Diabetes Diabetes mellitus Drug dosages Gelatinase A Gelatinase B Glucose Health risks Heart diseases Heart surgery Hospitals Hyperglycemia Immunosuppressive agents Insulin Intercellular adhesion molecule 1 Interleukin 6 Kinases MAP kinase Matrix metalloproteinase Matrix metalloproteinases Medical research Metalloproteinase Molecular modelling Monoclonal antibodies Muscles NF-κB protein Nuclear transport Protein kinase Proteins Rheumatoid arthritis Signaling Smooth muscle Software Statistical analysis Translocation
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