Effect of testosterone on morphine withdrawal syndrome in rats

Aim： To determine whether testosterone is involved in morphine withdrawal syndrome （WS）. Methods： In order to induce dependency, rats were treated with subcutaneous injection of morphine （days 1-2, 5 mg/kg; days 3-5, 7.5 mg/kg; days 6-8, 10 mg/kg）, and after the last dose of morphine （day 8） WS was...

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Veröffentlicht in:	Asian journal of andrology 2008-09, Vol.10 (5), p.765-769
Hauptverfasser:	Nayebi, Ali Reza Mohajjel, Rezazadeh, Hassan
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Androgens - pharmacology Androgens - physiology Animals Behavior, Animal castration Female flutamide Flutamide - pharmacology Male morphine Morphine - pharmacology Morphine Dependence - physiopathology Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Orchiectomy Rats Rats, Wistar Severity of Illness Index Substance Withdrawal Syndrome - physiopathology testosterone Testosterone - pharmacology Testosterone - physiology withdrawal syndrome 戒毒综合症睾丸激素
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